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楊慕華 (Muh-Hwa Yang)

楊慕華(Muh-Hwa Yang)圖 Appointment

[Profile]

  • Education
    • Ph.D., Institute of Clinical Medicine; National Yang-Ming University, Taipei, Taiwan, 2006
    • M.D., Faculty of Medicine; National Yang-Ming University, Taipei, Taiwan, 1994
  • Career and Experience
    Current Positions：
    • 2023- Now, Chief, Deparment of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
    • - Now, Senior Vice President and Provost (February 2021-present), National Yang Ming Chiao Tung University, Taipei, Taiwan
    • - Now, Chair Professor (Auguest 2016-present), Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
    • - Now, Director (February 2018-present), Cancer Progression Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan
    • - Now, Adjunct Research Fellow (August 2014-present), Genomic Research Center, Academia Sinica, Taipei, Taiwan
    Experiences：
    • 2015- 2022, Director (November 2015-), Division of Medical Oncology, Department of Oncology, Tapei Veterans General Hospital, Taipei, Taiwan
    • - , Assistant Professor (2007-2010), Associate Professor (2010-2013), Professor (2013-2016), Acting Director (2017-2018), Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
    • - , Attending Physician (September 2002-March 2015), Director (March 2015-November 2015), Division of Hematology-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
    • - , Resident (1996-1999), Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    • - , Chief Resident/Clinical Fellow (1999-2002), Division of Hematology-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
  • Medical Expertise
    1. Cancer Biology, Medical Oncology, Hematology, Internal Medicine, Head and Neck Cancer, Cancer Metastasis

[Publications]

PubMed

  1. Chang YW, Hsiao HW, Chen JP, Tzeng SF, Tsai CH, Wu CY, Hsieh HH, Carmona SJ, Andreatta M, Di Conza G, Su MT, Koni PA, Ho PC, Chen HK, Yang MH*. A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8(+) T cells. Cell Rep Med 2023 Aug 15.
  2. Chung CH, Lin CY, Chen CY, Hsueh CW, Chang YW, Wang CC, Chu PY, Tai SK, Yang MH*. Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer. Adv Sci (Weinh). 2023 Apr 7;e2204514.
  3. Chen HY, Hsieh, CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail regulated microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer 2022;10: e004832
  4. Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3 in colorectal cancer. Theranostics 2020; 10: 6095-6112.
  5. Li CF, Chen JY, Ho YH, Hsu WH, Wu, LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumor progression. Nat Cell Biol 2019; 21: 251-262. 
  6. Hwang WL*, Lan HY, Cheng WY, Huang SC, Yang MH*. Tumor stem-Like cells-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol 2019;12:10.
  7. Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH*. Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nat Commun 2018; 9:3763.
  8. Pan YR, Chen CC, Chan YT, Wang SJ, Chien FT, Chen YL, Liu JL, Yang MH*. STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas. Nat Commun 2018; 9:3696.
  9. Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, Yang MH*. Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clin Cancer Res 2017; 23: 4388-4401. 
  10. Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH*. let-7 modulates chromatin configuration and target gene repression through regulation of the ARID3B complex. Cell Rep 2016;14: 520-533. 
  11. Hsu DS, Wang SJ, Tai SK, Chou CH, Hsieh CH, Chiu PH, Chen NJ, Yang MH*. Acetylation of Snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell 2014; 26: 534-548. 
  12. Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW*, Yang MH*. MicroRNA-146a directs the symmetrical division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol 2014;16: 268-280.

 

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