Shyh-Kuan Tai, M.D. Ph.D.

 

Department

Department of Otolaryngology-Head and Neck Surgery,

Taipei Veterans General Hospital

Specialty

Head and neck surgical oncology

Laryngology

 

 

 

Education	M.D., School of Medicine, National Yang-Ming University, Taiwan Ph.D., Institue of Clinical Medicine, National Yang-Ming University, Taiwan
Major Professional Experiences
	Resident, Taipei Veterans General Hospital  Attending Physician, Department of Otolaryngology, Taipei Veterans General Hospital  Visiting instructor, Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center  Observer, Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center  Professor, Department of Otolaryngology, National Yang-Ming University
Clinical/Research interests
	Diagnosis and management of head and neck cancers/tumors (including oral cavity, oropharynx, larynx, hypopharynx cancers)  Diagnosis and management of neck mass (including thyroid and salivary gland tumors)  Head and neck minimally invasive robotic surgery  Diagnosis and management of obstructive sleep apnea  Diagnosis and management of voice disorders

 

Publications (First authod and corresponding author)

1. Tai SK, Yang MH, Chang SY, Chang YC, Li WY, Tsai TL, Wang YF, Chu PY, Hsieh SL*. (2011) Persistent KLF4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma. Cancer Sci 102(4):895-902. (SCI Journal)

2. Tai SK, Chang HC, Lan KL, Lee CT, Yang CY, Chen NJ, Chou TY, Tarng DC, Hsieh SL*. (2012) Decoy Receptor 3 Enhances Tumor Progression via Induction of Tumor-Associated Macrophages. J Immunol 118(5):2464-2471. (SCI journal)

3. Tai SK*, Li WY, Yang MH, Chang SY, Chu PY, Tsai TL, Wang YF, Chang PM. (2012) Treatment for T1-2 oral squamous cell carcinoma with or without perineural invasion: neck dissection and postoperative adjuvant therapy. Ann Surg Oncol 19(6):1995-2002. (SCI Journal)

4. Tai SK*, Li WY, Chu PY, Chang SY, Tsai TL, Wang YF, Huang JL. (2012) Risks and clinical implications of perineural invasion in T1-2 oral tongue squamous cell carcinoma. Head Neck 34(7):994-1001. (SCI Journal)

5. Kuo YY, Chu PY, Chang SY, Wang YF, Tsai TL, Yang MH, Wang LW, Tai SK*. (2013) Treatment selection for tonsillar squamous cell carcinoma. J Chin Med Assoc 76(4):211-217. (SCI Journal)

6. Tai, SK*, Li WY, Yang, MH, Chu PY, Wang YF. (2013) Perineural invasion in T1 oral squamous cell carcinoma indicates the need for aggressive elective neck dissection. Am J Surg Pathol 37(8):1164-1172. (SCI Journal)

7. Tai SK*, Li WY, Yang MH, Chu PY, Wang YF, Chang PM. (2013) Perineural invasion as a major determinant for the aggressiveness associated with increased tumor thickness in T1-2 oral tongue and buccal squamous cell carcinoma. Ann Surg Oncol 20(11):3568-3574. (SCI Journal)

Yeh CF, Li WY, Yang MH, Chu PY, Lu YT, Wang YF, Chang PM, Tai SK*. (2014) Neck observation is appropriate in T1-2, cN0 oral squamous cell carcinoma without perineural invasion or lymphovascular invasion. Oral Oncol 50(9):857-862. (SCI Journal)

Shyh-Kuan Tai, M.D. Ph.D.

 

Department

Department of Otolaryngology-Head and Neck Surgery,

Taipei Veterans General Hospital

Specialty

Head and neck surgical oncology

Laryngology

 

 

 

Education	M.D., School of Medicine, National Yang-Ming University, Taiwan Ph.D., Institue of Clinical Medicine, National Yang-Ming University, Taiwan
Major Professional Experiences
	Resident, Taipei Veterans General Hospital  Attending Physician, Department of Otolaryngology, Taipei Veterans General Hospital  Visiting instructor, Department of Thoracic/Head & Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center  Observer, Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center  Professor, Department of Otolaryngology, National Yang-Ming University
Clinical/Research interests
	Diagnosis and management of head and neck cancers/tumors (including oral cavity, oropharynx, larynx, hypopharynx cancers)  Diagnosis and management of neck mass (including thyroid and salivary gland tumors)  Head and neck minimally invasive robotic surgery  Diagnosis and management of obstructive sleep apnea  Diagnosis and management of voice disorders

 

Publications (First authod and corresponding author)

1. Cheng HY, Hsieh CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH. (2022) Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer 2022 Aug;10(8):e004832. doi: 10.1136/jitc-2022-004832.

2. Lee TL, Wei PY, Tai SK*. (2022) Effect of local anesthesia on pain scale and specimen adequacy in fine-needle aspiration biopsy of thyroid nodules for liquid-based cytology. Sci Rep 2022 Nov 2;12(1):18498. doi: 10.1038/s41598-022-23031-0.

3. Lee TL, Lee YT, Tai SK*. (2022) Neck management in T1-2 early-stage oral squamous cell carcinoma. International Journal of Head and Neck Science 2022;6(2):45-56.

4. Lai CL, Chen TH, Chang PM, Tai SK, Chu PY, Yang MH. (2022) Efficacy of cetuximab-containing regimens in the treatment of recurrent/metastatic head and neck cancer after progression to immune checkpoint inhibitors. J Chin Med Assoc 85(6):687-692.

5. Lee TL, Wei PY, Yang MH, Chang PM, Wang LW, Tai SK*. (2022) Tongue conservation treatment for oral tongue squamous cell carcinoma with induction chemotherapy, surgery, and risk-adapted adjuvant therapy: A phase II trial. Cancer Rep (Hoboken) 2022 Feb;5(2):e1456.

6. Ting KC, Lee TL, Li WY, Chang CF, Chu PY, Wang YF, Tai SK*. (2021) Perineural invasion/lymphovascular invasion double positive predicts distant metastasis and poor survival in T3-4 oral squamous cell carcinoma. Sci Rep 11(1):19770.

7. Huang YW, Wang YP, Lee TL, Chang CF, Hou MC, Tai SK, Chu PY. (2021) Image-enhanced endoscopy for detection of second primary esophageal neoplasms in patients with hypopharyngeal cancer: Prevalence, risk factors, and characteristics. J Chin Med Assoc 84(10):963-968

8. Lee TL, Wei PY, Yang MH, Chang PM, Wang LW, Tai SK*. (2021) Tongue conservation treatment for oral tongue squamous cell carcinoma with induction chemotherapy, surgery, and risk-adapted adjuvant therapy: A phase II trial. Cancer Rep (Hoboken). 2021 May 29:e1456.

9. Wu HL, Chu YH, Tai YH, Tsou MY, Wu CH, Lo WL, Tai SK, Yeh CC, Lu CC. (2020) Stage-dependent angiopoietin-Tie2 and nitric oxide signaling of erythrocytes in response to surgical trauma in head and neck cancer. World J Surg Oncol 18(1):209.

10. Yang CF, Niu DM, Tai SK, Wang TH, Su HT, Huang LY, Soong WJ. (2020) Airway abnormalities in very early treated infantile-onset Pompe disease: A large-scale survey by flexible bronchoscopy. Am J Med Genet A 182(4):721-729.

11. Lee TL, Chiu PH, Li WY, Yang MH, Wei PY, Chu PY, Wang YF, Tai SK*. (2019) Nerve-tumour interaction enhances the aggressiveness of oral squamous cell carcinoma. Clin Otolaryngol 44(6):1087-1095.

12. Wei PY, Li WY, Tai SK*. (2019) Discrete perineural invasion (PNI) focus number in PNI quantification for T1-2 oral squamous cell carcinoma. Otolaryngol Head Neck Surg 160(4):635-641.

13. Li CF, Chen JY, Ho YH, Hsu WH, Wu LC, Lan HY, Hsu DS, Tai SK, Chang YC, Yang MH. (2019) Snail-induced Claudin-11 prompts collective migration for tumor progression. Nat Cell Biol 21(2):251-262.

14. Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH. (2018) Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nat Commun 9(1):3763.

15. Hsieh CH, Tai SK, Yang MH. (2018) Snail-overexpressing cancer cells promote M2-Like polarization of tumor-associated macrophages by delivering MiR-21-abundant exosomes. Neoplasia 20(8):775-788.

16. Chen SC, Chang PM, Wang HJ, Tai SK, Chu PY, Yang MH. (2018) PD-L1 expression is associated with p16INK4A expression in non-oropharyngeal head and neck squamous cell carcinoma. Oncol Lett 15(2):2259-2265.

17. Chang PM, Chen CH, Yeh CC, Lu HJ, Liu TT, Chen MH, Liu CY, Wu ATH, Yang MH, Tai SK, Mochly-Rosen D, Huang CF. (2018) Transcriptome analysis and prognosis of ALDH isoforms in human cancer. Sci Rep 8(1):2713

18. Lu YT, Tai SK*, Lee TL*. (2018) Pterygomandibular suspension suture: a simple modification of uvulopalatopharyngoplasty for severe obstructive sleep apnea. Eur Arch Otorhinolaryngol 275(1):269-273.