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Pen-Yuan Chu

Pen-Yuan Chu, M.D.

 

Department

Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital

Specialty

Laryngology

Head and Neck Oncology

 

 

 

Education

M.D., National Defense Medical Center, Taiwan, R.O.C.

Clinical investigator, Memorial Sloan-Kettering Cancer Center, New York, N.Y., U.S.A.

 

 

 

Major Professional Experiences

 

 

 Resident, Taipei Veterans General Hospital

 Attending Physician, Taipei Veterans General Hospital

 Chief of the Laryngology-Head and Neck Surgery, Department of Otolaryngology -Head & Neck Surgery, Taipei Veterans General Hospital

 Professor, Department of Otolaryngology, School of Medicine, National Yang-Ming University, Taipei, Taiwan

 

Clinical/Research interests

 

 

 Diagnosis and management of head and neck cancers/tumors (including oral cancer, laryngeal cancer, hypopharyngeal cancer, thyroid cancer, and salivary gland tumor)

 Transoral laser microsurgery (minimal invasive surgery) for laryngeal preservation

 Diagnosis and management of voice disorders
       

 

Publications (First authod and corresponding author)

  1. Lee TL, Chen TH, Kuo YJ, Lan HY, Yang MH*, Chu PY*. Tumor-associated tissue eosinophilia promotes angiogenesis and metastasis in head and neck squamous cell carcinoma. Neoplasia. 2023 Jan;35:100855. doi: 10.1016/j.neo.2022.100855. Epub 2022 Nov 19. (2021 IF=6.218, Ranking=66/245 in ONCOLOGY)
  2. Liu CH, Chien PJ, Hung LT, Wang LM, Kao YC, Tsai YJ, Chu PY*. Long-term Oncologic Results and Voice Outcomes in Patients With Glottic Cancer After Modified Type III Cordectomy. Otolaryngol Head Neck Surg. 2022 Nov;167(5):839-845. (2021 IF=5.591, Ranking=3/43 in OTORHINOLARYNGOLOGY)
  3. Cheng HY, Hsieh CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer. 2022 Aug;10(8):e004832. (2021 IF=12.485, Ranking=25/245 in ONCOLOGY)
  4. Lai CL, Chen TH, Chang PM, Tai SK, Chu PY, Yang MH*. Efficacy of cetuximab-containing regimens in the treatment of recurrent/metastatic head and neck cancer after progression to immune checkpoint inhibitors. J Chin Med Assoc. 2022 Jun 1;85(6):687-692. (2021 IF=3.396, Ranking=71/172 in MEDICINE, GENERAL & INTERNAL)
  5. Liao CT, Wen YW, Lee SR, Ng SH, Liu TW, Tsai ST, Tsai MH, Lin JC, Chien CY, Lou PJ, Wang CP, Chu PY, Leu YS, Tsai KY, Terng SD, Chen TM, Wang CH, Chen WC, Lee LY, Lin CY, Wang HM, Fang TJ, Huang SF, Kang CJ, Chang KP, Yen TC, Yang LY*, Lin CH*; Taiwan Oral Cavity Cancer Advisory Group. Clinical Outcomes of Taiwanese Patients with Resected Oral Cavity Squamous Cell Carcinoma Who Underwent Reconstruction with Free Versus Local Flaps. Ann Surg Oncol. 2022 Feb;29(2):1130-1140. (2021 IF=4.339, Ranking=37/213 in SURGERY)
  6. Ting KC, Lee TL, Li WY, Chang CF, Chu PY, Wang YF, Tai SK*. Perineural invasion/lymphovascular invasion double positive predicts distant metastasis and poor survival in T3-4 oral squamous cell carcinoma. Sci Rep. 2021 Oct 5;11(1):19770. (2021 IF=4.997, Ranking=19/74 in MULTIDISCIPLINARY SCIENCES)
  7. Huang YW, Wang YP, Lee TL, Chang CF, Hou MC, Tai SK, Chu PY*. Image-enhanced endoscopy for detection of second primary esophageal neoplasms in patients with hypopharyngeal cancer: Prevalence, risk factors, and characteristics. J Chin Med Assoc. 2021 Oct 1;84(10):963-968. (2021 IF=3.396, Ranking=71/172 in MEDICINE, GENERAL & INTERNAL)
  8. Lin MC, Leu YS, Chiang CJ, Ko JY, Wang CP, Yang TL, Chen TC, Chen CN, Chen HL, Liao CT, Tsai ST, Lin JC, Chu PY, Tsai KY, Tsai MH, Huang HC, Yang MH, Wu YH, Terng SD, Chien CY, Liu TW, Lee WC, Lou PJ*. Adequate surgical margins for oral cancer: A Taiwan cancer registry national database analysis. Oral Oncol. 2021 Aug;119:105358. (2021 IF=5.972, Ranking=6/92 in DENTISTRY, ORAL SURGERY & MEDICINE)
  9. Chien PJ, Hung LT, Wang LW, Yang MH, Chu PY*. Oncologic results and quality of life in patients with T3 glottic cancer after transoral laser microsurgery. Eur Arch Otorhinolaryngol. 2021 Aug;278(8):2983-2992. (2021 IF=3.236, Ranking=12/43 in OTORHINOLARYNGOLOGY)
  10. Chang H, Chu PY*. Extramedullary plasmacytoma of hypopharynx treated using transoral laser microsurgery and adjuvant radiotherapy. J Chin Med Assoc. 2020 Aug;83(8):791-793. (2021 IF=3.396, Ranking=71/172 in MEDICINE, GENERAL & INTERNAL) CASE REPORT
  11. Lee TL, Chiu PH, Li WY, Yang MH, Wei PY, Chu PY, Wang YF, Tai SK*  Nerve-tumour interaction enhances the aggressiveness of oral squamous cell carcinoma. Clin Otolaryngol. 2019 Nov;44(6):1087-1095. (2021 IF=2.729, Ranking=19/43 in OTORHINOLARYNGOLOGY)
  12. Lee SC*, Wang TJ*, Chu PY*. Predictors of weight loss during and after radiotherapy in patients with head and neck cancer: A longitudinal study. Eur J Oncol Nurs. 2019 Apr;39:98-104. (2021 IF=2.588, Ranking=32/123 in NURSING)
  13. Cheng YJ, Tsai MH, Chiang CJ, Tsai ST, Liu TW, Lou PJ, Liao CT, Lin JC, Chang JT, Tsai MH, Chu PY, Leu YS, Tsai KY, Terng SD, Chien CY, Yang MH, Hao SP, Wang CC, Tsai MH, Chen HHW, Kuo C, Wu YH*. Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome-A Taiwan Cancer Registry national database analysis. Cancer Med. 2018 Jun 14;7(7):3073-83. (2021 IF=4.711, Ranking=106/245 in ONCOLOGY)
  14. Hsu CC, Li WY, Chu PY*. Salivary duct carcinoma of the supraglottis with a distinct presentation: A case report and literature review. Medicine (Baltimore). 2018 Mar;97(11):e0095. CASE REPORT
  15. Chen SC, Chang PM, Wang HJ, Tai SK, Chu PY*, Yang MH*. PD-L1 expression is associated with p16INK4A expression in non-oropharyngeal head and neck squamous cell carcinoma. Oncol Lett. 2018 Feb;15(2):2259-2265. (2021 IF=3.111, Ranking=176/245 in ONCOLOGY)
  16. Hung LT, Huang HI, Wang LW, Yang MH, Chu PY*. Oncologic results and quality of life in patients with squamous cell carcinoma of hypopharynx after transoral laser microsurgery. Lasers Surg Med. 2018 Feb;50(2):117-124. (2021 IF=2.703, Ranking=95/213 in SURGERY)

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