陳明德醫師   Ming-Teh Chen, M.D., Ph.D.

Degree:

Taipei Medical University, MD

National Defense Medical Center, PhD

Hospital Appointments:

Senior Consultant, Department of Education, Taipei Veterans General Hospital

Attending Neurosurgeon, Department of Neurosurgery, Taipei Veterans General Hospital

Academic Appointments:

Associate Professor, Faculty of Medicine, School of medicine, National Yang Ming Chiao Tung University

Clinical Professor, Faculty of Medicine, School of medicine, National Defense Medical Center

Past Appointments:

Section Chief, Division of Faculty Development, Department of Education, Taipei Veterans General Hospital

Fellow, Department of Neurosurgery, University of California, Los Angeles, USA

Post-doctor fellow, Intramural Program, National Institute on Drug Abuse, National Institutes of Health, USA

Expertise:

Clinical: Skull base surgery, Brain tumor surgery, Spine surgery, Neurosurgical intensive care

Research: Molecular biology of brain tumors, Neuro-electro-physiology

Office Address:

Department of Neurosurgery

Taipei Veterans General Hospital

201, Sec. 2, Shi-Pai Road,

Taipei, Taiwan

11217

E-mail:

mtchen@vghtpe.gov.tw

Publications:

1. Ping-Hsing Tsai, Yun-Ching Chang, Yi-Yen Lee, Yu-Ling Ko, Yu-Hsuan Yang,Chun-Fu Lin, Yuh-Lih Chang, Wen-Chung Yu, Yang-Hsin Shih, Ming-Teh Chen. Differentiation of blood T cells: Reprogramming human induced pluripotent stem cells into neuronal cells. Journal of the Chinese Medical Association 78 (2015) 353-359
2. Wei-Hsiu Liu, Ming-Teh Chen, Mong-Lien Wang, Yi-Yen Lee, Guang-Yuh Chiou, Chian-Shiu Chien, Pin-I Huang, Yi-Wei Chen, Ming-Chao Huang, Shih-Hwa Chiou, Yang-Hsin Shih, Hsin-I Ma. Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells. Oncotarget. 2015 Jan 30;6(3):1750-68
3. Ping-Hsing Tsai, Yun-Ching Chang, Yi-Yen Lee, Yu-Ling Ko, Yu-Hsuan Yang, Chun-Fu Lin, Yuh-Lih Chang, Wen-Chung Yu, Yang-Hsin Shih, Ming-Teh Chen. Differentiation of blood T cells: Reprogramming human induced pluripotent stem cells into neuronal cells. Journal of the Chinese Medical Association. 2015 Jun;78(6):353-9
4. Yi-Yen Lee, Yi-Ping Yang, Pin-I Huang, Wen-Cheng Lie, Ming-Chao Huang,  Chung-Lan Kao, Yann-Jang Chen, Ming-Teh Chen. Exercise suppresses COX-2 pro-inflammatory pathway in vestibular migraine. Brain Research Bulletin. 2015 Jul;116:98-105
5. Lu-Jen Chen, I-Chun Lai, Tai-Tong Wong, Shih-Chieh Lin, Donald Ming-Tak Ho, Wan-Yuo Guo, Sang-Hue Yen, Kai-Ping Chang, Ming-Teh Chen, Yi-Wei Chen. Can mixed pure hepatocellular carcinoma and germinoma arise together in the brain? Journal of the Chinese Medical Association. 2015 Sep; 78(9):562-6
6. Wei-Hsin Wang, Cheng-Chia Lee, Huai-Che Yang, Kang-Du Liu, Hsiu-Mei Wu, Cheng-Ying Shiau, Wang-You Guo, David Hung-Chi Pan, Wen-Yuh Chung, Ming-Teh Chen. Gamma knife radiosurgery for atypical and anaplastic meningioma. World Neurosurgery. 2016 Mar; 87:557-64
7. Hsiao-Yun Chen, Liang-Ting Lin, Mong-Lien Wang, Shu-Hsien Lee,, Ming- Long Tsai1, Chi-Chang Tsai, Wei-Hsiu Liu, Tzu-Chien Chen, Yi-Ping Yang, Yi- Yen Lee, Yuh-Lih Chang, Pin-I Huang, Yi-Wei Chen, Wen-Liang Lo, Shih- Hwa Chiou, Ming-Teh Chen. Musashi-1 regulates AKT-derived IL-6 a autocrinal/paracrinal malignancy and chemoresistance in glioblastoma. Oncotarget, 2016 Jul 5;7(27):42485-42501
8. Wen-Shin Song, Yi-Ping Yang, Chi-Shuan Huang,  Kai-Hsi Lu, Wei-Hsiu Liu, Wei-Hwa Wu, Sheua-Dong lee, Yi-Wei Chen, Pin-I Huang, Ming-Teh Chen. Sox2, stemness gene, regulated tumor-initiating and drug-resistant property in CD133-positive glioma stem cells. Journal of the Chinese Medical Association 2016 Oct;79(10):538-45
9. Tzu-Wei Lin, Ming-Teh Chen, Liang-Tin Lin, Pin-I Huang, Wen-Liang Lo, Yi-Ping Yang, Kai-Hsi Lu, Yi-Wei Chen, Shih-Hwa Chiou, Cheng-Wen Wu. TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma. Oncotarget. 2017 May 18;8(34):56612-56625
10. Hsiao-Yun Chen, Liang-Ting Lin, Mong-Lien Wang, Kun-Ling Tsai, Pin-I Huang, Yi-Ping Yang, Yi-Yen Lee, Yi-Wei Chen, Wen-Liang Lo, Yuan-Tzu Lan, Shih-Hwa Chiou, Chien-Min Lin, Hsin-I Ma, Ming-Teh Chen. Musashi-1 promotes chemoresistant granule formation by PKR/eIF2α signalling cascade in refractory glioblastoma. Biochim Biophys Acta. 2018 May;1864(5 Pt A):1850-1861
11. Yi-Yen Lee, Aliaksandr A Yarmishyn, Mong-Lien Wang, Hsiao-Yun Chen, Shih-Hwa Chiou, Yi-Ping Yang, Chun-Fu Lin, Pin-I Huang, Yi-Wei Chen, Hsin-I Ma, Ming-Teh Chen. MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells. Cancer Management and Research. 2018 Apr 12;10:775-785
12. Yi-Ping Yang, Phan Nguyen Nhi Nguyen, Hsin-I Ma, Wen-Jin Ho, Yi-Wei Chen, Yueh Chien, Aliaksandr A. Yarmishyn, Pin-I Huang, Wen-Liang Lo, Chien-Ying Wang, Yung-Yang Liu , Yi-Yen Lee, Chien-Min Lin, Ming-Teh Chen, Mong-Lien Wang. Tumor mesenchymal stromal cells regulate cell migration of atypical teratoid rhabdoid tumor through exosome-mediated miR155/SMARCA4 pathway. Cancers (Basel). 2019 May 24;11(5)