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▍Research Laboratories
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Laboratory of Neurovascular Research

Tel : 886-2-28712121 Ext. 8143
E-mail: spchen2@vghtpe.gov.tw
Principal Investigator: Shih-Pin Chen

Education

2006-2010  Ph.D., Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

1995-2002  M.D., School of Medicine, National Yang-Ming University, Taipei, Taiwan

Training

M.D., School of Medicine, National Yang-Ming University, Taipei, Taiwan

Ph.D., Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

Postdoctoral research fellow, Neurovascular Research Lab, Massachusetts General Hospital, Harvard Medical School

Current Position

Attending Physician, Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital (2017-)

Attending Physician, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital (2008-)

Professor, Institute of Clinical Medicine, National Yang-Ming University (2019-)

Adjunct Professor, Institute of Neuroscience, National Yang-Ming University (2019-)

Adjunct Professor, Taiwan International Graduate Program- Interdisciplinary Neuroscience (TIGP-INS), Academia Sinica- National Yang-Ming University Joint Curriculum (2019-)

Secretary General, Asian Regional Consortium of Headache (2018-)

Associate Editor, Cephalalgia (The Official Journal of International Headache Society) (2020-)

Associate Editor, Cephalalgia Reports (2020-)

Quality Control Supervisor, Joint Tissue Bank (Bone, Eye and Skin), Taipei Veterans General Hospital (2020-)

Secretary General, Asian Regional Consortium of Headache (2019-)

Executive Secretary, Cell Therapy Committee, Taipei Veterans General Hospital (2019-)

Director, Cell Therapy Core Laboratory, Taipei Veterans General Hospital (2019-)

Director, Neurovascular Research Lab, Taipei Veterans General Hospital (2017-)

Director, Management Center of Medical Sciences & Technology Building, Taipei Veterans General Hospital (2017-)

Chair, Committee of Research Ability Training Curriculum for Faculty Development, Taipei Veterans General Hospital (2017-)


Education and Trainings

M.D., School of Medicine, National Yang-Ming University, Taipei, Taiwan

Ph.D., Institute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanPostdoctoral research fellow, Neurovascular Research Lab, Massachusetts General Hospital, Harvard Medical School

Resident, the Neurological Institute, Taipei Veterans General Hospital


Administrative appoints

Director, Management Center of Medical Sciences & Technology Building, Taipei Veterans General Hospital (2017-)

Chair, Committee of Research Ability Training Curriculum for Faculty Development, Taipei Veterans General Hospital (2017-)

Infection Control Committee, Taipei Veterans General Hospital (2009-2012, 2014-2016)

Secretary General, Taiwan Headache Society (2011-2012)

Licensure

National Board of Medical License, TAIWAN


Specialty Board

Diplomate in Neurology, Taiwan Board of Neurology

Board of Neurocritical Care, Taiwan


Membership in Medical and Scientific Societies

Member, International Headache Society, 2012-

Member, American Academy of Neurology, 2006-

Member, Taiwan Headache Society, 2005-

Member, Taiwan Movement Society, 2006-

Member, Taiwan Epilepsy Society, 2006-

Member, Taiwan Neurological Society, 2002-


Awards

2006  Best poster award, Headache section, Taiwan Neurological Society

2008  Best poster award, Headache section, Taiwan Neurological Society

2009  Best poster award, Headache section, Taiwan Neurological Society

2009  Excellent Doctor Award, 2009, Veterans Affairs Commission, Executive Yuan, Taiwan, ROC. Nominated for outstanding clinical teaching.

2011  Academic Prize for Excellent Research, Taipei Veterans General Hospital.

2012  Government-funded study abroad scholarship award, Taipei Veterans General Hospital, Veterans Affairs Commission, Executive Yuan, Taiwan, ROC.

2013  Taipei Veterans General Hospital - National Yang-Ming University Excellent Physician Scientist Cultivation Scholarship Award.

2016  Excellent Teacher Award, Faculty of Medicine, National Yang-Ming University.

2016  Excellent Doctor Award, 2016, Veterans Affairs Commission, Executive Yuan, Taiwan, ROC. Nominated for outstanding clinical teaching.

2017  Excellent Teacher Award, Faculty of Medicine, National Yang-Ming University.

2018  Most cited paper award. Awarded for highly cited article published in Pain in 2016. Pain (Wolters Kluwer publisher).

2018  Excellent Teacher Award, Faculty of Medicine, National Yang-Ming University.

2018  Excellent Mentor Award, Faculty of Medicine, National Yang-Ming University.

2018  Excellent Doctor Award, 2018, Veterans Affairs Commission, Executive Yuan, Taiwan

2019  Excellent Teacher Award, Faculty of Medicine, National Yang-Ming University

2019  Excellent Teacher Award, Institute of Clinical Medicine, School of Medicine, National Yang-Ming University

2019  Excellent Teaching Award, National Yang-Ming University

2019  Ta-You Wu Memorial Award, Ministry of Science and Technology, Taiwan

2019  Academic Prize for Excellent Research, Taipei Veterans General Hospital.

2020  Excellent Teacher Award, Institute of Clinical Medicine, School of Medicine, National Yang-Ming University

2020  Excellent Teaching Award, National Yang-Ming University

2020  Outstanding Teaching Award of Graduate Schools in National Yang-Ming University (#1 voted by graduate students)  

2021  Excellent Teacher Award, School of Medicine, National Yang Ming Chiao Tung University

2021  Excellent Teacher Award, Institute of Clinical Medicine, College of Medicine, National Yang-Ming University

2021  Excellent Teaching Award, College of Medicine, National Yang Ming Chiao Tung University 

2021  Tien Te Lee Biomedical & Technology Award 

2021  Physician Innovative Award (1st prize), Taipei Veterans General Hospital

2022  Outstanding Research Award, Ministry of Science and Technology, Taiwan 

2022  Excellent Teacher Award, School of Medicine, National Yang Ming Chiao Tung University

2022  Academic Prize for Excellent Research, Taipei Veterans General Hospital.


Editorial responsibilities

Section Editor, Current Pain and Headache Reports (Chronic daily headache section) (2021-)

Review Editor, Frontiers in Neurology (Headache & Neurogenic Pain) (2021-)

Associate Editor, Cephalalgia (2020-2022)

Associate Editor, Cephalalgia Reports (2020-2022)

Academic Editor, PeerJ (2017-2019)

Junior Editor, Cephalalgia (2018-2019)

Junior Editor, Cephalalgia Reports (2018-2019)


International Academic Committee

Editorial Advisory Board of the CGRP Education and Research Forum (2017-)

Chair, Posterwalk session, 18th Congress of the International Headache Society (Vancouver, Canada, 2017)

Research Interest

My clinical expertise include headache, neurodegenerative diseases and neuroimmunological disorders.

My research interest focuses on deciphering the neurobiology for complex neurovascular disorders, specifically on reversible cerebral vasoconstriction syndrome (RCVS) and migraine. The main reason for studying these two headache disorders is that RCVS is one of the most severe and dangerous headache disorders that causes tremendous impact to the sufferers and migraine is a highly prevalent disorder that causes the most disease burden and socioeconomic impact among all neurological disorders in the world. Moreover, both disorders have limited therapeutic options and enigmatic pathophysiology. My goals are to combine clinical and basic researches to revolutionize diagnostic strategies, elucidate disease mechanism, explore potential disease-targeting therapy, and thereby reduce the burden on patients and the medical providing system.
Selected Publications (2015-2023, *corresponding author)
  1. Chen PY, Yen JC, Liu TT, Chen ST, Wang SJ, Chen SP*. Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation. Brain 2023 July; 146(7): 2989–3002, doi: 10.1093/brain/awad045.
  2. Wu CH, Hsu TW, Lai KL, Wang YF, Fuh JL, Wu HM, Lirng JF*, Wang SJ, Chen SP.* Disrupted brain functional status in patients with reversible cerebral vasoconstriction syndrome. Annals of Neurology 2023 Oct;94(4):772-784. doi: 10.1002/ana.26724.
  3. Wu CH, Kuo Y, Chang FC, Lirng JF, Ling YF, Wang YF, Wu HM, Fuh JL, Lin CJ, Wang SJ*, Chen SP*. Noninvasive investigations of human glymphatic dynamics in a diseased model. European Radiology 2023 Jul 4. doi: 10.1007/s00330-023-09894-5.
  4. Chen SP. Migraine and treatment-resistant depression. Progress in Brain Research. 2023;281:149-173. doi: 10.1016/bs.pbr.2023.05.001.
  5. Winsvold BS, …Chen SP, … for the International Consortium for Cluster Headache Genetics. Cluster headache genome‐wide association study and meta‐analysis identifies eight loci and implicates smoking as causal risk factor. Annals of Neurology 2023 DOI: 10.1002/ana.26743
  6. Kuan AS, Chen SP, Wang YF, Wang SJ. Prolonged headache with vaccine- and dose-specific headache pattern associated with vaccine against SARS-CoV-2 in patients with migraine. Cephalalgia 2023 Oct;43(10):3331024231208110
  7. Hsu SL, Liao YC, Wu CH, Chang FC, Chen YL, Lai KL, Chung CP, Chen SP*, Lee YC*. Glymphatic dysfunction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Communications 2023 in press
  8. Hsiao FJ, Chen WT, Wu YT, Pan LLH, Wang YF, Chen SP, Lai KL, Gianluca C, Wang SJ. Characteristic oscillatory brain networks for predicting patients with chronic migraine. The Journal of Headache and Pain. 2023 Oct 18;24(1):139. doi: 10.1186/s10194-023-01677-z.
  9. Wang YF, Tzeng YS, Yu CC, Ling YH, Chen SP, Lai KL, Chen WT, Wang SJ. Sex differences in the clinical manifestations related to dependence behaviors in medication-overuse headache. The Journal of Headache and Pain. 2023 Nov 1;24(1):145. doi: 10.1186/s10194-023-01685-z.
  10. Chen SP,Takizawa T, Sekiguchi K, Nakahara Jin, Wang SJ*. COVID-19 vaccination elicited de novo and recurrence of cluster headache: a case series. Cephalalgia 2023 in press
  11. Hsiao FJ, Chen WT, Wang YF, Chen SP, Lai KL, Gianluca C, Wang SJ*. Identification of patients with chronic migraine by using sensory-evoked oscillations from the electroencephalogram classifier. Cephalalgia 2023 May. 43(5): 1–11
  12. Chuang CH, Li JY, King JT, Chen WT, Chen SP, Wang YF, Liu HY, Hsiao FJ, Pan LLH, Wang SJ, Lai KL*. Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study. Cephalalgia 2023 Oct;43(10):3331024231206781.
  13. Lange K, Choi SY, Ling YH, Chen SP, Mawet J, Duflos C, Lee MJ, Ducros A, Wang SJ*, Pezzini A*. Reversible cerebral Vasoconstriction syndrome intERnational CollaborativE (REVERCE) network: study protocol and rationale of a multicentre research collaboration. European Stroke Journal 2023.
  14. Chen YJ, Hu KF, Chan C, Huang C, Huan YH, Wang YF, Wang SJ, Chen SP*, Lee MH*. Association of Periodontal Disease with Migraine: A Large-Scale Community-Based Cross-Sectional Study. Headache 2023 Apr;63(4):539-548. doi: 10.1111/head.14491. (*equal contribution)
  15. Wu JW, Chen ST, Wang YF, Lai KL, Chen TY, Chen SP, Chen WT, Wang SJ*. Sphenopalatine Ganglion Volumetry in Episodic Cluster Headache: From Symptom Laterality to Cranial Autonomic Symptoms. The Journal of Headache and Pain. 2023; 24:2
  16. Lin PT, Wang YF*, Hseu SS, Fuh JL, Lirng JF, Wu JW, Chen ST, Chen SP, Chen WT, Wang SJ. The SIH-EBP Score: A Grading Scale to Predict the Response to the First Epidural Blood Patch in Spontaneous Intracranial Hypotension. Cephalalgia 2023 Mar;43(3):3331024221147488.
  17. Lin PT, Chen SP, Wang SJ*. Update on sex-induced headache and primary thunderclap headache. Cephalalgia 2023, 43(3): 1–10
  18. Wang YF *, Tzeng YS, Yu CC, Ling YH, Chen SP, Lai KL, Wang SJ. Clinical utility of Leeds Dependence Questionnaire in medication-overuse headache. Diagnostics 2023, 13(3), 472; https://doi.org/10.3390/diagnostics13030472
  19. Tsao YC, Wang YF, Fuh JL, Chen WT, Lai KL, Liu HY, Wang SJ*, Chen SP*. Transient visual disturbance is associated with disability and suicidal risk in patients with migraine without aura. Journal of the Chinese Medical Association 2023 Jun 1;86(6):557-564. doi: 10.1097/JCMA.0000000000000912.
  20. Chou TM, Lee ZF, Wang SJ, Lien CC*, Chen SP*. CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. The Journal of Headache and Pain. 2022; 23:157 https://doi.org/10.1186/s10194-022-01531-8
  21. Chen SP*, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. Journal of Biomedical Science. 2022; 29:72
  22. Tsao YC, Wang YF, Fuh JL, Chen WT, Lai KL, Liu HY, Wang SJ, Chen SP*. Non-aura visual disturbance with high visual aura rating scale scores has stronger association with migraine chronification than typical aura. Cephalalgia 2022 Nov 23, 42(14) 1487–1497
  23. Chen SP, Hsu CL, Wang YF, Yang FC, Chen TH, Huang JH, Pan LLH, Fuh JL, Chang HC, Lee YL, Chang HC, Lee KH, Chang YC, Fann CSJ, Wang SJ. Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan. The Journal of Headache and Pain 2022; 23:147. https://doi.org/10.1186/s10194-022-01517-6
  24. Jiang YJ, Fann CSJ; Fuh JL, Chung MY, Huang HY, Chu KC, Wang YF, Hsu CL, Kao LS, Chen SP*, Wang SJ*. Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs. The Journal of Headache and Pain. 2022 Mar 29;23(1):39 doi: 10.1186/s10194-022-01409-9. (*equal contribution; equal contribution).
  25. Tsao YC, Wang SJ, Hsu CL, Wang YF, Fuh JL, Chen SP*, Fann CSJ*. Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population. Cephalalgia 2022 Mar;42(3):229-238. doi: 10.1177/03331024211037269 (*equal contribution)
  26. Hsiao FJ*, Chen WT*, Pan LLH, Liu HY, Wang YF, Chen SP, Lai KL, Coppola G, Wang SJ. Resting‑state magnetoencephalographic oscillatory connectivity to identify patients with chronic migraine using machine learning. The Journal of Headache and Pain 2022; 23:130. https://doi.org/10.1186/s10194-022-01500-1.
  27. Liu HY, Lee PL, Chou KH, Wang YF, Chen SP, Lai KL, Pan LL, Lin CP, Wang SJ, Chen WT*. Brain morphometry changes with fatigue severity in fibromyalgia. Clin Exp Rheumatol. 2022 Sep 6. doi: 10.55563/clinexprheumatol/zviutu
  28. Liu TT, Morais A, Takizawa T, Mulder I, Simon B, Chen SP, Wang SJ, Ayata C*, Yen JC*. Efficacy of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model. The Journal of Headache and Pain. 2022 Jan 21;23(1):12. doi: 10.1186/s10194-022-01384-1.
  29. Wang YF, Liao YC, Tzeng YS, Chen SP, Lirng JF, Fuh JL, Chen WT, Lai KL, Lee YC*, Wang SJ*. Mutation screening and association analysis of NOTCH3 p.R544C in patients with migraine with or without aura. Cephalalgia 2022 Aug;42(9):888-898. doi: 10.1177/03331024221080891.
  30. Pan LLH, Wang YF, Ling YH, Lai KL, Chen SP, Chen WT, Treede RD, Wang SJ*. Pain sensitivities predict prophylactic treatment outcomes of flunarizine in chronic migraine patients: a prospective study. Cephalalgia. 2022 Aug;42(9):899-909. doi: 10.1177/03331024221080572.
  31. Pan LLH, Chen WT, Wang YF, Chen SP, Lai KL, Liu HY, Hsiao FJ*, Wang SJ*. Resting-state occipital alpha power is associated with treatment outcome in patients with chronic migraine. Pain. 2022 Jul 1;163(7):1324-1334. doi: 10.1097/j.pain.0000000000002516.
  32. Tu YH, Wang YF, Yuan HK, Chen SP, Tzeng YS, Chen WT, Lai KL, Ling YH, Wang SJ. Most bothersome symptoms in patients with migraine: a hospital-based study in Taiwan. Headache 2022 May;62(5):596-603. doi: 10.1111/head.14308.
  33. Chou PC, Liu CM, Weng CH, Yang KC, Cheng ML, Lin YC, Yang RB, Shyu BC, Shyue SK, Liu JD, Chen SP, Hsiao M, Hu YF. Fibroblasts drive metabolic reprogramming in pacemaker cardiomyocytes. Circulation Research 2022 Jun 24;131(1):6-20. doi: 10.1161/CIRCRESAHA.121.320301.
  34. Liu HY, Chou KH, Lee PL, Wang YF, Chen SP, Lai KL, Lin CP, Wang SJ, Chen WT. Right anterior insula is associated with pain generalization in patients with fibromyalgia. Pain 2022 Apr 1;163(4):e572-e579. doi: 10.1097/j.pain.0000000000002409.
  35. Hsiao FJ, Chen WT, Pan H. LL, Liu HY, Wang YF, Chen SP, Lai KL, Coppola G., Wang SJ. Dynamic brainstem and somatosensory cortical excitability during migraine cycles. The Journal of Headache and Pain. 2022 Jan. 23(1), 1-12
  36. Liaw YC, Wang YF, Chen WT, Chen SP, Wu JW, Chen ST, Lai KL, Fuh JL, Wang SJ*. Sex-related differences in cluster headache: a hospital-based study in Taiwan. Cephalalgia 2022 Dec;42(14):1532-1542. doi: 10.1177/03331024221120054
  37. Lin YL, Wong WY, Yang ZS, Wang SJ, Chen SP, Cheng JK, Lu H, Lien CC*. Cellular Mechanisms Underlying Central Sensitization in a Mouse Model of Chronic Muscle Pain. eLife 2022 Nov 15;11:e78610. doi: 10.7554/eLife.78610.
  38. Wu CH, Wu HM, Ling YH, Wang YF, Fuh JL, Lin CJ, Ling K, Lirng JF, Wang SJ, Chen SP*. Blood brain barrier permeability in patients with reversible cerebral vasoconstriction syndrome assessed with dynamic contrast-enhanced MRI. Neurology 2021 Nov 2;97(18):e1847-e1859.
  39. Wu CH, Lirng JF, Ling YH, Wang YF, Wu HM, Fuh JL, Lin PC, Wang SJ*, Chen SP*. Noninvasive characterization of human glymphatics and meningeal lymphatics in an in vivo model of blood-brain barrier leakage. Annals of Neurology 2021;89:111–124 (*Equal contribution)
  40. Chen SP, Chang YA, Chou CH, Juan CC, Lee HC, Chen LK, Wu PC, Wang YF, Fuh JL, Lirng JF, Ducros A, Huang HD*, Wang SJ*. Circulating microRNAs associated with Reversible Cerebral Vasoconstriction Syndrome. Annals of Neurology 2021;89:459–473
  41. Hsiao FJ, Chen WT, Wang YF, Chen SP, Lai KL, Liu HY, Pan LH, Wang SJ. Somatosensory gating responses are associated with prognosis in patients with migraine. Brain Sciences 2021 Jan 28;11(2):166. doi: 10.3390/brainsci11020166.
  42. Lee ZF, Huang TH, Chen SP*, Cheng IH*. Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling. Pain 2021 Jun 1;162(6):1669-1680. (*Equal contribution)
  43. Hsiao FJ, Chen WT, Liu HY, Wang YF, Chen SP, Lai KL, Coppola G, Wang SJ. Migraine chronification is associated with beta-band connectivity within the pain network. Pain 2021 Oct 1;162(10):2590-2598.
  44. Ling YH, Wang YF, Lirng JF, Fuh JL, Wang SJ, Chen SP*. Post-reversible cerebral vasoconstriction syndrome headache. The Journal of Headache and Pain. 2021; 22(1): 1-8
  45. Lin PT, Wang YF, Fuh JL, Lirng JF, Ling YH, Chen SP*, Wang SJ*. Diagnosis and Classification of Headache Associated with Sexual Activity Using a Composite Algorithm: a cohort study. Cephalalgia 2021 Dec;41(14):1447-1457 (*Equal contribution)
  46. Wang YF, Yu CC, Kuan AS, Chen SP, Wang SJ. Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study. The Journal of Headache and Pain 2021 May 10;22(1):36. doi: 10.1186/s10194-021-01248-0.
  47. Yen HH, Chien C, Lee IH, Chen SP, Luo CB, Lin CJ, Chen ST, Yuan WH, Kuo Y, Wu CH*, Chang FC*. Application of flat-panel volume computed tomography to evaluate cerebral hemorrhage after mechanical thrombectomy of acute embolic stroke of the anterior circulation. J Comput Assist Tomogr 2021 Nov-Dec 01;45(6):919-925.
  48. Liu YH, Guo YC, Lin LY, Tsai CP, Fuh JL, Wang YF, Chen SP, Wu HM, Yu KW, Lin KP, Wang SJ, Liao YC*, Lee YC*. Treatment response, risk of relapse, and clinical characteristics of Taiwanese patients with neuromyelitis optica spectrum disorder. Journal of the Formosan Medical Association 2021 Nov 18;S0929-6646(21)00499-X. doi: 10.1016/j.jfma.2021.11.002.
  49. Tai CS, Wu SL, Lin SY, Liang Y, Wang SJ, Chen SP*. The causal-effect of bed rest and post-dural puncture headache in patients receiving diagnostic lumbar puncture- A prospective cohort study. Journal of the Chinese Medical Association 2021 Aug 1;84(8):791-794.
  50. Liu HY, Chou KH, Lee PL, Wang YF, Chen SP, Lai KL, Lin CP, Wang SJ, Chen WT. The right anterior insula is associated with pain generalization in patients with fibromyalgia. Pain 2021 Jul 13. doi: 10.1097/j.pain.0000000000002409.
  51. Ling YH, Chen SP*. Narrative Review: Headaches after Reversible Cerebral Vasoconstriction Syndrome. Current Pain and Headache Reports. 2020;24 (12), 1-4
  52. Hsiao FJ, Chen WT, Ko YC, Liu HY, Wang YF, Chen SP, Lai KL, Lin HY, Coppola G, Wang SJ. Neuromagnetic amygdala response to pain-related fear as a brain signature of fibromyalgia. Pain Ther. 2020 Oct 22. doi: 10.1007/s40122-020-00206-z
  53. Hsiao FJ, Chen WT, Liu HY, Wang YF, Chen SP, Lai KL, Pan LL, Wang SJ. Individual pain sensitivity is associated with resting-state cortical activities in healthy individuals but not in patients with migraine: a magnetoencephalography study. The Journal of Headache and Pain 2020; 21:133. https://doi.org/10.1186/s10194-020-01200-8
  54. Cho SH, Ling YH, Lee MJ, Chen SP, Fuh L, Lirng JF, Cha JH, Wang YF, Wang SJ*, Chung CS*. Temporal profile of blood-brain barrier breakdown in reversible cerebral vasoconstriction syndrome. Stroke 2020 May;51(5):1451-1457. (Equal contribution)
  55. Hsu WH, Wang SJ, Chao YM, Chen CJ, Wang YF, Fuh JL, Chen SP*, Lin YL. Urine metabolomics signatures in reversible cerebral vasoconstriction syndrome. Cephalalgia 2020 Jun; 40(7):735-747.
  56. Huang C, Chen SP, Huang YH, Chen HY, Wang YF, Lee MH*, Wang SJ.* HLA class I alleles are associated with chronic migraine and medication overuse in migraineurs. Cephalalgia 2020 April. 40(5) 493–502. (Equal contribution)
  57. Liu JH, Wang TW, Lin YY, Ho WC, Tsai HC, Chen SP, Lin AM, Liu TY, Wang HT. Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation. Experimental Neurology 2020 Jan;323:113066.
  58. Sprouse Blum AS, Lavoie B, Haag M, Mawe SM, Tolner EA, van den Maagdenberg AM., Chen SP, Eikermann-Haerter K, Ptáček L., Mawe GM, Shapiro RA. No gastrointestinal dysmotility in transgenic mouse models of migraine. Headache 2020 Feb;60 (2): 396-404
  59. Morais A, Liu TT, Qin T, Sadhegian H, Ay I, Yagmur D, Mendes da Silva R, Chung D, Simon B, Guedes R, Chen SP, Wang SJ, Yen JC*, Ayata C*. Vagus nerve stimulation inhibits cortical spreading depression exclusively via central mechanisms. Pain 2020 Jul;161 (7):1661-1669
  60. Liu HY, Lee PL, Chou KH, Lai KL, Wang YF, Chen SP, Chen WT*, Wang SJ*. The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine. The Journal of Headache and Pain. 2020 Mar 18;21(1):29.
  61. Peng KP*, Chen SP, Gudmundsson LS. Headache highlights 2019: Junior editors’ choice. Cephalalgia Reports 2020: 3, 2515816320903292
  62. Wu JW, Wang YF, Hseu SS, Chen ST, Chen YL, Wu YT, Chen SP, Lirng JF, Wang SJ*. Brain volume changes in spontaneous intracranial hypotension: revisiting the Monro-Kellie Doctrine. Cephalalgia 2020 in press
  63. Pan YJ, Chen YC, Lu SR, Juang KD, Chen SP, Wang YF, Fuh JL, Wang SJ*. The influence of friendship on migraine in young adolescents: a social network analysis. Cephalalgia 2020 Jul 7:333102420940700. doi: 10.1177/0333102420940700.
  64. Pan LL, Wang YF, Lai KL, Chen WT, Chen SP, Ling YH, Chou LW, Treede RD, Wang SJ*. Mechanical punctate pain threshold is associated with headache frequency and phase in patients with migraine. Cephalalgia 2020 Aug;40(9):990-997
  65. Huang WC, Chen SP, Wang SJ*. Are surgically remediable headaches associated with cervical spondylosis equivalent to “cervicogenic headaches”? Neurospine 2020 Jun;17(2):374-376
  66. Harriott AM, Takizawa T, Chung DY, Chen SP*. Spreading Depression as a Preclinical Model of Migraine. The Journal of Headache and Pain 2019 May 2;20(1):45.
  67. Yalcin N, Chen SP, Yu ES, Liu TT, Yen JC, Atalay YB, Qin T, Celik F, van den Maagdenberg AM, Moskowitz MA, Ayata C, Eikermann-Haerter K*. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab 2019 Apr;39(4):740-750. (Equal contribution)
  68. Shih YC, Chen SP*, Fuh JL, Wang YF, Wang SJ. Influence of climate on the incidence of RCVS – a retrospective study from Taiwan. Headache 2019; 59(4): 567-575.
  69. Kuan AS, Chen SP, Wang YF, Fuh JL, Cheng CY, Peng KP, Wang SJ. Risk factors and psychological impact of syncope in migraine patients. Cephalalgia 2019 Dec;39(14):1838-1846.
  70. Ling YH, Chen SP, Fann CS, Wang SJ, Wang YF*. TRPM8 genetic variant is associated with chronic migraine and allodynia. The Journal of Headache and Pain 2019;20(1):115
  71. Chen SP*, Chou KH, Fuh JL, Huang YH, Huang CC, Lirng JF, Wang YF, Lin CP, Wang SJ.* Dynamic Changes in White Matter Hyperintensities in Reversible Cerebral Vasoconstriction Syndrome. JAMA Neurology 2018;75(9):1106-1113. (*Equal contribution)
  72. Chen CY, Chen SP*, Fuh JL, Lirng JF, Chang FC, Wang YF, Wang SJ. Vascular Wall Imaging in Reversible Cerebral Vasoconstriction Syndrome - A 3-T Contrast-enhanced MRI study. The Journal of Headache and Pain 2018; 19: 74.
  73. Wu JW, Wang YF, Fuh JL, Lirng JF, Chen SP, Hseu SS, Wang SJ. Correlations among brain and spinal MRI findings in spontaneous intracranial hypotension. Cephalalgia 2018: 38(14): 1998-2005.
  74. Cheng CY, Cheng HM, Chen SP, Chung CP, Lin YY, Hu HH, Chen CH, Wang SJ*. White matter hyperintensities in migraine: Clinical significance and central pulsatile hemodynamic correlates. Cephalalgia 2018; 38(7):1225-1236
  75. Tsou HH, Hsu WC, Fuh JL, Chen SP, Liu TY, Wang HT. Alterations in acrolein metabolism contribute to Alzheimer’s disease. Journal of Alzheimer’s Disease. 2018;61(2):571-580
  76. Cheng CY, Chen SP, Liao YC, Fuh JL, Wang YF, Wang SJ. Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study. Cephalalgia 2018;38(9):1585-1591
  77. Chang YH, Luo CB, Wang SJ, Chen SP*. Cluster headache and middle meningeal artery dural arteriovenous fistulas: A case report. Cephalalgia 2018; 38(11): 1792–1796
  78. Chou TM, Chen SP*. Animal Models of Chronic Migraine. Current Pain and Headache Reports. 2018: 19;22(6):44.
  79. Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AM., Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-Panx1 complex suppresses spreading depolarization and neuroinflammation. Brain 2017; 140:1643-1656
  80. Lai KL, Niddam DM, Fuh JL, Chen SP, Wang YF, Chen WT, Wu JC, Wang SJ.* Flunarizine versus topiramate for chronic migraine prophylaxis: a randomized trial. Acta Neurol Scand. 2017; 135:476-483.
  81. Oka F, Hoffmann U, Lee JH, Shin HK, Chung D, Yuzawa I, Chen SP, Atalay YB, Nozari A, Park K, Qin T, Ayata C.* Requisite ischemia for spreading depolarizations after subarachnoid haemorrhage. J Cereb Blood Flow Metab 2017; 37:1829-1840
  82. Wu JW, Hseu SS, Fuh JL, Lirng JF, Wang YF, Chen WT, Chen SP, Wang SJ*. Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension. Brain 2017;140:344-52.
  83. Chen SP, Fuh JL, Chung MY, Lin YC, Liao YC, Wang YF, Hsu CL, Yang YC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, Chen YT, Kao LS*, Fann CS*, Wang SJ*. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. Cephalalgia 2018; 38: 466-75 (Equal contribution)
  84. Pan YR, Juang KD, Lu SR, Chen SP, Wang YF, Fuh JL*, Wang SJ*. Longitudinal risk factors for suicidal thoughts in depressed and non-depressed young adolescents. Aust N Z J Psychiatry. 2017; 51(9):930-937.
  85. Chen YC, Wang YF, Li JY, Chen SP, Lirng JF, Hseu SS, Tung H, Cheng PL, Wang SJ,* Fuh JL.* Treatment and prognosis of subdural hematoma in patients with spontaneous intracranial hypotension. Cephalalgia 2016; 36: 225-31
  86. Chen SP,* Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain 2016; 157: 797-805
  87. Chen SP, Tolner EA,* Eikermann-Haerter K.* Animal models of monogenic migraine. Cephalalgia 2016; 36: 704-21
  88. Chen PR, Lai KL, Fuh JL, Chen SP, Wang PN, Liao KK, Wang SJ.* Efficacy of continuous theta burst stimulation of the primary motor cortex in reducing migraine frequency: a preliminary open-label study. J Chin Med Assoc. 2016; 79:304-8
  89. Chen SP, Ayata C.* Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2016; 20(7):44. doi: 10.1007/s11916-016-0574-8.
  90. Lee WJ, Wu SL, Li JY, Chen CC, Ling JJ, Peng GS, Lin TK, Wang SJ, Chen RS, Yang YH, Tsai CH, Hsu JL, Liao YC, Chen SP, Fuh JL.* PDD-5S: A Useful Screening Tool for Parkinson’s Disease Dementia. Parkinsonism & Related Disorders 2016; 25: 85-90.
  91. Fuh JL, Chung MY, Yao SC, Chen PK, Liao YC, Hsu CL, Wang PJ, Wang YF, Chen SP, Fann CS, Kao LS, Wang SJ.* Susceptible Genes of Restless Legs Syndrome in Migraine. Cephalalgia 2016; 36: 1028-1037
  92. Akhter M,* Chen SP. Vascular Emergencies and Shared Decision Making in Patients with Thunderclap Headache. Academic Emergency Medicine. 2016; 23:1194-1195
  93. Chen PR, Chen SP.* Posterior Reversible Encephalopathy as the First Manifestation of Bickerstaff's Brainstem Encephalitis. BMC Neurology 2016; 16: 215
  94. Wu HY, Hseu SS, Chen SP, Lirng JF, Wang YF, Wang SJ, Fuh JL. Spontaneous intracranial hypotension complicated by malignancy-induced disseminated intravascular coagulation: A case report. Acta Neurologica Taiwanica 2016;25:95-98.
  95. Chen SP, Fuh JL, Lirng JF, Wang YF, Wang SJ.* Recurrence of Reversible Cerebral Vasoconstriction Syndrome: a Long-Term Follow-up Study. Neurology 2015; 84: 1-7
  96. Wang YF, Fuh JL, Lirng JF, Chen SP, Hseu SS, Wu JC, Wang SJ.* Cerebrospinal fluid leakage and headache after lumbar puncture: a prospective non-invasive imaging study. Brain 2015; 138(Pt 6):1492-8
     

Review Articles (*corresponding author)

  1. Chen SP, Eikermann-Haerter K.* How imaging can help us better understand the migraine-stroke connection. Headache 2020 Jan;60(1):217-228.
  2. Harriott AM, Takizawa T, Chung DY, Chen SP*. Spreading Depression as a Model of Migraine. The Journal of Headache and Pain 2019;20(1):45.
  3. Tolner E. *, Chen SP, Eikermann-Haerter K. Current understanding of cortical structure and function in migraine. Cephalalgia 2019 Nov;39(13):1683-1699.
  4. Chou TM, Chen SP*. Animal Models of Chronic Migraine. Current Pain and Headache Reports. 2018: 19;22(6):44.
  5. Chen SP, Ayata C.* Novel Therapeutic Targets against Spreading Depression. Headache 2017;57:1340-1358.
  6. Chen SP, Ayata C.* Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2016; 20(7):44.
  7. Chen SP, Tolner EA,* Eikermann-Haerter K.* Animal models of monogenic migraine. Cephalalgia 2016; 36: 704-21
  8. Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes: Current and future perspectives. Expert Rev Neurother 2011; 11:1265-76.
  9. Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes- an under-recognised clinical emergency. Ther Adv Neurol Disord 2010; 3: 161-71.


Textbook Chapters (*corresponding author)

  1. Takizawa T, Ayata C, Chen SP*. Therapeutic implications of cortical spreading depression models in migraine in Progress in Brain Research. Edited by Lau and Shuu-Jiun Wang. 2020 Elsevier B.V.
  2. Chen SP, Theriot J, Brennan KC, Ayata C*. Chapter 19. Animal model of migraine aura. Neurobiologic Basis of Migraine. 1st ed. Edited by Turgay Dalkara and Michael A. Moskowitz. JohnWiley & Sons, Inc., 2017
  3. Chen SP, Wang SJ*. Chapter 18. Headaches due to vascular disorders. Modern Day Management of Headache- Questions and Answers. Edited by K Ravishankar, Randolph W Evans and Shuu-Jiun Wang. Jaypee- The Health Science Publishers, 2017
  4. Chen SP, Pascual J, Wang SJ*. Chapter 25: Exertional and Sex Headache– In Michel Ferrari, Joost Haan, Andrew Charles, David Dodick, and Fumihiko Sakai (eds.), Oxford Textbook of Headache Syndromes (Oxford Textbooks in Clinical Neurology), Oxford Press, 2016
  5. Chen SP, Wang SJ*. Chapter 15. Reversible cerebral vasoconstriction syndrome. International Neurology. 2nd edition; DOI: 10.1002/9781118777329.ch15. John Wiley & Sons, Ltd, 2016

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