TEL: +886-2-2875-7627 (FB)

1995/07  National Tsing Hua University, Hsinchu, Taiwan, M. S. in Life Science

2000/10  National Defense Medical Center, Taipei, Taiwan, Ph. D. in Life Sciences

2005/01 ~ Present  Associate Research Investigator, Department of Medical Research, Taipei Veterans General Hospital

2001/01 ~ 2005/12 Post Doctor, Department of Medical Research and Education, Taipei Veterans General Hospital

2005/10 ~ 2011/07 Adjunct Assistant Professor, Institute of Biophotonics, National Yang-Ming University

2007/08 ~ 2011/07 Adjunct Assistant Professor, Department of Microbiology, Soochow University

2011/08 ~ 2021/01 Adjunct Associate Professor, Institute of Biophotonics, National Yang-Ming University

2021/02 ~ 2022/07 Adjunct Associate Professor, Institute of Biophotonics, National Yang Ming Chiao Tung University

1. Biophotonics & biomedical engineering
2. Fluorescence resonance energy transfer (FRET)
3. Pb biosensor
4. In vivo biosensing
5. Smart healthcare & biomedical detection
6. Precision environmental on-site Pb detection

1. Development & optimization of Pb biosensors; molecular simulation for new design
2. Organelle accumulation of Pb under long-term exposure; the investigation on the molecular mechanism of Pb toxicology
3. In vivo Pb monitoring 1: mapping of Pb-sensitive neuronal circuit within transgenic Drosophila brain
4. In vivo Pb monitoring 1: monitoring  the accumulation of Pb in transgenic crops
5. Construction & optimization of portable Pb sensing device for on-site Pb detection

1. Optimization and Practical Applications of Fret-Based Biosensor: from Updating Portable Pb Sensor Device to Mapping Pb-Sensitive Circuitry    2021/08/01 ~ 2023/07/31     MOST 110-2320-B-075-005    (PI)
2. The establishment of heavy metal warning system for home health maintenance by the optimized portable lead sensing device    2023/01/01 ~ 2023/12/31     V112C-002      (PI)

1. METHOD AND BIOSENSOR FOR LEAD IONS DETECTION/鉛離子的偵測方法及生物感應器 Taiwan, I779550 (2022.10.01 ~ 2041-04.06)
2. METHOD AND BIOSENSOR FOR LEAD IONS DETECTION Indonesia, approved

1. 2022 2^nd Winner of Scientific Literature Competition – basic research group, Taipei Veterans General Hospital (Biosensors 2021)
2. 2022 2^nd Winner of Innovation (Improvement) – basic research group, Taipei Veterans General Hospital
3. 2022 Winner of Activist for Influence (SDG), U20 Youth Forum, Corporate Social Responsibility (CSR) @ CommonWealth Magazine
4. 2021 Winner of Scientific Literature Competition – basic research group, Taipei Veterans General Hospital (Bios Bioelec 2020)
5. 2021 Best Potential Award of Genius For Home - Digital Social Innovation Competition, MediaTek Foundation
6. 2021 3^rd Winner of Sustainable Development Goals Research Poster Awards, National Yang Ming Chiao Tung University (Instruct student Lai WQ)
7. 2021 2^nd Winner of Master Thesis Competition, Institute of Biophotonics, National Yang Ming Chiao Tung University (Instruct student Lai WQ)
8. 2021 Excellent Work of Infinite-Dimensional - Smart Healthcare Competition, National Central University
9. 2020 Winner of Infinite-Dimensional - Smart Healthcare Competition, National Central University
10. 2020 2^nd Winner of Innovation (Improvement) – basic research group, Taipei Veterans General Hospital
11. 2014 2^nd Winner of Scientific Literature Competition – basic research group, Taipei Veterans General Hospital (PLos ONE 2013)
12. 2013 Winner of Scientific Literature Competition – basic research group, Taipei Veterans General Hospital (Tox. Sci. 2012)
13. 2013 Winner of Innovation (Improvement) – basic research group, Taipei Veterans General Hospital (microscopic imaging)
14. 2012 Winner of Innovation (Improvement) – basic research group, Taipei Veterans General Hospital (heavy metal biosensor)

1. 揪出鉛毒危機！陽明交大、北榮攜手業界 開發行動裝置搭配手機驗鉛水 (https://ynews.page.link/xR1K)
2. 恭喜北榮研究團隊: 生物感應測鉛方法研究登 Elsevier 旗下優質期刊 (https://reurl.cc/gMZKpz)
3. FRET技術搭配手機驗鉛水，陽明生醫光電所師生競賽成果優異! (https://reurl.cc/605Njd)

1. Lai WQ, Huang TC, Liang KH, Chang YF, Yang DM.* Portable sensing devices for smart healthcare and prevention of lead poisoning. J Chin Med Assoc. 2022 Nov; accepted. (IF=3.396; 71/172, General & Internal Medicine)
2. Wang ML, Lin Y, Hou JF, Yang YP, Chien Y, Sun YC, Liang KH, Yang DM, Chang TJ, Wu CH, Kao SY, Hung KF. The Omicron variant wave: Where are we now and what are the prospects? J Chin Med Assoc. 2023 Feb;86(2):135-137. doi: 10.1097/JCMA.0000000000000863. PMID: 36524941 (IF=3.396; 71/172, General & Internal Medicine)
3. Yang DM,* Chang TJ, Hung KF, Wang ML, Chen YF, Chiang SH, Chen MF, Liao YT, Lai WQ, Liang KH.* Smart healthcare: a prospective future medical approach for COVID-19. J Chin Med Assoc. 2023 Feb 1;86(2):138-146. doi: 10.1097/JCMA.0000000000000824. Epub 2022 Oct 13. PMID: 36227021; PMCID: PMC9847685. (IF=3.396; 71/172, General & Internal Medicine)
4. Liang KH, Hung KF, Wang ML, Chang TJ, Cheng YF, Chiang SH, Chen MF, Liao YT, Chiou SH, Yang DM.* SARS-CoV-2 vaccines in children and adolescents: Can immunization prevent hospitalization? J Chin Med Assoc. 2022 Sept;85(9):891-895. doi: 10.1097/JCMA.0000000000000774. Epub ahead of print. PMID: 35816282. (IF=3.396; 71/172, General & Internal Medicine)
5. Chen CW, Chen LK, Huang TY, Yang DM, Liu SY, Tsai PJ, Chen TH, Lin HF, Juan CC. Nitric Oxide Mobilizes Intracellular Zn(2+) via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation. Int J Mol Sci. 2022 May 14;23(10):5488. doi: 10.3390/ijms23105488. PMID: 35628299; PMCID: PMC9143299. (IF=5.924)
6. Lai WQ, Chang YF, Chou FN, Yang DM.* Portable FRET-Based Biosensor Device for On-Site Lead Detection. Biosensors (Basel). 2022 Mar 2;12(3):157. doi: 10.3390/bios12030157. PMID: 35323427; PMCID: PMC8946079. (IF=5.743; 8/64, Instruments & Instrumentation)
7. Lien CC, Yin WH, Yang DM, Chen LK, Chen CW, Liu SY, Kwok CF, Ho LT, Juan CC. Endothelin-1 induces lipolysis through activation of the GC/cGMP/Ca(2+)/ERK/CaMKIII pathway in 3T3-L1 adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb;1867(2):159071. doi: 10.1016/j.bbalip.2021.159071. Epub 2021 Nov 5. PMID: 34748972.
8. Yang DM,* Chang YF. Versatile Cell and Animal Models for Advanced Investigation of Lead Poisoning. Biosensors (Basel). 2021 Oct 4;11(10):371. doi: 10.3390/bios11100371. PMID: 34677327; PMCID: PMC8533970. (IF=5.743; 8/64, Instruments & Instrumentation)
9. Chang TJ, Lai WQ, Chang YF, Wang CL, Yang DM.* Development and optimization of heavy metal lead biosensors in biomedical and environmental applications. J Chin Med Assoc. 2021 Aug 1;84(8):745-753. doi: 10.1097/JCMA.0000000000000574. PMID: 34225337. (IF=3.396; 71/172, General & Internal Medicine)
10. Yang DM,* Lin FC, Tsai PH, Chien Y, Wang ML, Yang YP, Chang TJ.* Pandemic analysis of infection and death correlated with genomic open reading frame 10 mutation in severe acute respiratory syndrome coronavirus 2 victims. J Chin Med Assoc. 2021 May 1;84(5):478-484. doi: 10.1097/JCMA.0000000000000542. PMID: 33883466. (IF=3.396; 71/172, General & Internal Medicine)
11. Yang DM,* Fu TF, Lin CS, Chiu TY, Huang CC, Huang HY, Chung MW, Lin YS, Manurung RV, Nguyen PNN, Chang YF.* High-performance FRET biosensors for single-cell and in vivo lead detection. Biosens Bioelectron. 2020 Nov 15;168:112571. doi: 10.1016/j.bios.2020.112571. Epub 2020 Aug 31. PMID: 32892119. (IF=12.545; 3/87, Analytical Chemistry)
12. Tsai PH, Wang ML, Yang DM, Liang KH, Chou SJ, Chiou SH, Lin TH, Wang CT, Chang TJ. Genomic variance of Open Reading Frames (ORFs) and Spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). J Chin Med Assoc. 2020 Aug;83(8):725-732. doi: 10.1097/JCMA.0000000000000387. PMID: 32773643; PMCID: PMC7493783. (IF=3.396; 71/172, General & Internal Medicine)
13. Liang KH, Chang TJ, Wang ML, Tsai PH, Lin TH, Wang CT, Yang DM. Novel biosensor platforms for the detection of coronavirus infection and severe acute respiratory syndrome coronavirus 2. J Chin Med Assoc. 2020 Aug;83(8):701-703. doi: 10.1097/JCMA.0000000000000337. PMID: 32349033; PMCID: PMC7493778. (IF=3.396; 71/172, General & Internal Medicine)
14. Yang DM,* Chang TJ, Wang ML, Tsai PH, Lin TH, Wang CT, Liang KH. Hunting severe acute respiratory syndrome coronavirus 2 (2019 novel coronavirus): From laboratory testing back to basic research. J Chin Med Assoc. 2020 Jun;83(6):524-526. doi: 10.1097/JCMA.0000000000000332. PMID: 32502116; PMCID: PMC7199774. (IF=3.396; 71/172, General & Internal Medicine)
15. Chang TJ, Yang DM, Wang ML, Liang KH, Tsai PH, Chiou SH, Lin TH, Wang CT. Genomic analysis and comparative multiple sequences of SARS-CoV2. J Chin Med Assoc. 2020 Jun;83(6):537-543. doi: 10.1097/JCMA.0000000000000335. PMID: 32349035. (IF=3.396; 71/172, General & Internal Medicine)
16. Ghosh S, Chang YF, Yang DM, Chattopadhyay S. Upconversion nanoparticle- mOrange protein FRET nanoprobes for self-ratiometric/ratiometric determination of intracellular pH, and single cell pH imaging. Biosens Bioelectron. 2020 May 1;155:112115. doi: 10.1016/j.bios.2020.112115. Epub 2020 Feb 26. PMID: 32217331. (IF=12.545; 3/87, Analytical Chemistry)
17. Tu YF, Chien CS, Yarmishyn AA, Lin YY, Luo YH, Lin YT, Lai WY, Yang DM, Chou SJ, Yang YP, Wang ML, Chiou SH. A Review of SARS-CoV-2 and the Ongoing Clinical Trials. Int J Mol Sci. 2020 Apr 10;21(7):2657. doi: 10.3390/ijms21072657. PMID: 32290293; PMCID: PMC7177898. (IF=5.924)
18. Yang DM,* Huang CC, Chang YF. Combinatorial roles of mitochondria and cGMP/PKG pathway in the generation of neuronal free Zn2+ under the presence of nitric oxide. J Chin Med Assoc. 2020 Apr;83(4):357-366. doi: 10.1097/JCMA.0000000000000280. PMID: 32101891. (IF=3.396; 71/172, General & Internal Medicine)
19. Yang DM,* Manurung RV, Lin YS, Chiu TY, Lai WQ, Chang YF, Fu TF. Monitoring the Heavy Metal Lead Inside Living Drosophila with a FRET-Based Biosensor. Sensors (Basel). 2020 Mar 19;20(6):1712. doi: 10.3390/s20061712. PMID: 32204388; PMCID: PMC7146181. (IF=3.847; 15/64, Instruments & Instrumentation)
20. Gupta A, Lam CW, Wu CT, Yang DM, Chattopadhyay S. Photothermal Disintegration of 3T3 Derived Fat Droplets by Irradiated Silica Coated Upconversion Nanoparticles. Part. Part. Syst. Charact. 2018, 35, 1800294. doi: 10.1002/ppsc.201800294.
21. Hung HH, Kao LS, Liu PS, Huang CC, Yang DM, Pan CY. Dopamine elevates intracellular zinc concentration in cultured rat embryonic cortical neurons through the cAMP-nitric oxide signaling cascade. Mol Cell Neurosci. 2017 Jul;82:35-45. doi: 10.1016/j.mcn.2017.04.006. Epub 2017 Apr 17. PMID: 28427888.