1984  B.S., Dept. Chem., Natl. Taiwan Normal Univ.

1993  Ph.D., Dept. Chem., Univ. Calif., San Diego, USA

1993 ~ 1996  Postdoc. Fellow, Inst. Biomed., Academia Sinica

1996 ~ 2000  Assoc. Investigator, Dept. Med. Res. & Edu., Veterans General Hospital-Taipei

1998 ~ 2000  Adjunct Assoc. Prof., Grad. Inst. Biochem., Natl. Yang-Ming Univ.

2000~ 2016   Adjunct Assoc. Investigator, Dept. of Med. Res. & Edu., Taipei Veterans General Hospital

2016 ~ present   Adjunct Investigator, Dept. of Med. Res., Taipei Veterans General Hospital

2000~ 2007  Assoc. Prof., Grad. Inst. Biochem., Natl. Yang-Ming Univ.

2007 ~ present  Prof., Grad. Inst. Biochem., Natl. Yang-Ming Univ.

2007 ~ present  Prof., Grad. Inst. Biomedical Informatics., Natl. Yang-Ming Univ.

2007 ~ present  Prof., Grad. Inst. Biochemistry and Molecular Biology., Natl. Yang-Ming Univ

2007 ~ present Prof., Department of Life Sciences & Grad. Inst. Genome Sciences., Natl. Yang-Ming Univ.

1. Alzheimer’s disease is thought to be associated with aggregation of β-amyloid peptide (Aβ). The aggregation process of Aβ involves conformational changes, suggesting that the structural property and conformational stability play an important role in Aβ aggregation. It has been shown that genetically mutated Aβ, which cause early-onset familial Alzheimer’s disease (FAD), are more prone to aggregation than wild-type Aβ, suggesting that genetic mutation might alter the structural property and conformational stability of Aβ. Currently, we are investigating the effect of genetic mutation on Aβ structure. Study of the effect of Aβ structure on its aggregation behavior may help us gain more insight into Aβ aggregation mechanism from the structural point of view.
2. Human apolipoprotein E (apoE) has been known to play a key role in the transport of plasma cholesterol and lipoprotein metabolism. It is also highly associated with late-onset familial and sporadic Alzheimer’s disease (AD). ApoE has three major isoforms, apoE2, apoE3, and apoE4. The three isoforms differ from one another only by one or two amino acids, but have markedly differences in their biological functions. The lipid- and receptor-binding abilities of apoE are isoform-specific, suggesting that structural characteristics of apoE isoforms might play important roles in their functions. We are interested in the structure-functional relationship of apoE isoforms.
3. Protein phosphatase 1 (PP1) is one of the major serine/threonine eukaryotic protein phosphatases. It plays a critical role in the regulation of various cellular functions, including carbohydrate metabolism, protein synthesis, cell cycle, muscle contraction and neuronal signaling. The catalytic subunit of PP1 in cells is associated with different binding proteins to form a variety of holoenzymes. These binding proteins may target the enzyme to specific subcellular compartments in which PP1 regulates the functions of its substrates. The catalytic subunit of PP1 is specifically regulated by three protein inhibitors, inhibitor-1, DARPP-32 (dopamine and cAMP-regulated phosphoprotein of apparent Mr 32,000) and inhibitor-2. The inhibition of PP1 is regulated through phosphorylation of these protein inhibitors. Our goal is to understand the molecular mechanisms of PP1 regulation from the structural point of view.
4. The ubiquitin specific proteases (USPs) comprise the largest family of deubiquitinases (DUBs). Ubiquitin Specific Enzymes (USP) are potential drug targets. The strong connection of USPs with cancer phenotypes makes USPs attractive for the cancer drug discovery purposes. Develop a lead compound for structure-based design of USP inhibitors.
5. Institute of Biochemistry & Molecular Biology, NYCU website: https://biochem.nycu.edu.tw/english/faculty/full-time/lin-ta-hsien/

1. Y-Ren Lai, Jinn-Tsyy Lai, Steven S.-S. Wang*, Young-Chih Kuo*, Ta-Hsien Lin*, "Silver nanoparticle-deposited whey protein isolate amyloid fibrils as catalysts for the reduction of methylene blue", 2022, International Journal of Biological Maeromolecules, 176, 490-497. IF: 8.025, 5 yr IF: 7.626, Ranking (Polymer Science): 6/90, 6.11% (2021 JCR).
2. Shu-Shun Hsueh, Steven S.-S. Wang, Shu-Han Chen, Chia-Lin Wang, Josephine W. Wu*, Ta-Hsien Lin*, "Insights to Human D-Crystallin Unfolding by NMR Spectroscopy and Molecular Dynamics Simulations", 2022, International Journal of Molecular Sciences, 23, 1591. IF: 6.208, 5 yr IF: 6.628, Ranking (Biochemistry & Molecular Biology): 69/296, 23.14% (2021 JCR).
3. Hsu-Feng Chu, Shu-Chun Cheng, Chiao-Yin Sun, Chi-Yuan Chou, Ta-Hsien Lin*, Wei-Yi Chen*, "Structural and Biochemical Characterization of PEDV Papain-like Protease 2", 2022, Journal of virology, 96, e01372-21. IF: 6.549, 5 yr IF: 5.780, Ranking (Virology): 9/38, 22.37% (2021 JCR).
4. Tai-Jay Chang*, Cheng-Yuan Hsia, Gar-Yang Chau, Liang-Tsai Hsiao, Kuang-Tzu Huanga, Kung-Liang King, Wing-Yiu Lui, Anna F.-Y Li, Chia-Lin Wang, Pin-Hsing Tsai, Yueh Chien, Ta-Hsien Lin*, "Characterization of Androgen Receptor Complex Associated Protein (ARCAP) in Hepatocellular Carcinoma and Liver", 2021, Journal of the Chinese Medical Association, 84, 1100-1108. IF: 3.396, 5 yr IF: 3.046, Ranking (Medicine, General& Internal-Sciences): 78/329, 23.56% (2021 JCR).
5. Yu-Ting Huang, An-Chieh Cheng, Hui-Chi Tang, Guo-Cheng Huang, Ling Cai, Ta-Hsien Lin, Kou-Juey Wu6 Ping-Hui Tseng, Greg G. Wang and Wei-Yi Chen, "USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer", 2021, Cell Death and Disease, 12:880. IF: 9.705, 5 yr IF: 8.713, Ranking (Cell Biology): 37/194, 17.78% (2021 JCR).
6. Hsin-Cheng Lin, Ying Kuan, Hsu-Feng Chu, Shu-Chun Cheng, Heng-Chih Pan, Wei-Yi Chen, Chiao-Yin Sun*, Ta-Hsien Lin*, "Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21", 2021, International Journal of Biological Macromolecules, 176, 490–497. IF: 8.025, 5 yr IF: 7.626, Ranking (Polymer Science): 6/90, 6.11% (2021 JCR).
7. Su-Chun How, Ta-Hsien Lin*, Chun-Chao Chang*, Steven S.-S. Wang*, "Examining the effect of bovine serum albumin on the properties and drug release behavior of β-lactoglobulin-derived amyloid fibril-based hydrogels", 2021, International Journal of Biological Macromolecules, 184, 79–91. IF: 8.025, 5 yr IF: 7.626, Ranking (Polymer Science): 6/90, 6.11% (2021 JCR).
8. Shu-Shun Hsueh, Jian-Hong Lu, Josephine W. Wu*, Ta-Hsien Lin*, Steven S.-S. Wang*, "Protection of human γD-crystallin protein from ultraviolet C-induced aggregation by ortho-vanillin", 2021, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 261, 120023. IF: 4.831, 5 yr IF: 4.073, Ranking (Spectroscopy): 5/43, 10.47% (2021 JCR).
9. Kai-Cyuan He, Yi-Ru Chen, Chu-Ting Liang, Shi-Jie Huang, Chung-Ying Tzeng, Chi-Fon Chang, Shing-Jong Huang, Hsien-Bin Huang*, Ta-Hsien Lin*, "Conformational Characterization of Native and L17A/F19A-Substituted Dutch-Type β-Amyloid Peptides", 2020, International Journal of Molecular Sciences, 21, 2571. IF: 6.208, 5 yr IF: 6.628, Ranking (Biochemistry & Molecular Biology): 67/296, 23.14% (2021 JCR).
10. Yu-Shan Lin, Kuang-Yung Huang, Hui-Chun Yu, Ming-Chi Lu, Cheng-Jhong Fan, Hsien-Yu Huang Tseng, Bi-Yao Jhuang, Su-Qin Liu, Ning-Sheng Lai*, Ta-Hsien Lin*, Hsien-Bin Huang*, "Identification of phostensin in association with Eps 15 homology domain-containing protein 1 and 4", 2020, Biochemical and Biophysical Research Communications, 531, 236-241. IF: 3.322, 5 yr IF: 3.498, Ranking (Biophysics): 39/72, 53.47% (2021 JCR).
11. De-Ming Yang*, Tai-Jay Chang, Mong-Lien Wang, Ping-Hsing Tsai, Ta-Hsien Lin, Chin-Tien Wang, Kung-Hao Liang, "Hunting severe acute respiratory syndrome coronavirus 2 (2019 novel coronavirus): From laboratory testing back to basic research", 2020, Journal of the Chinese Medical Association, 83, 524-526. IF: 3.396, 5 yr IF: 3.046, Ranking (Medicine, General& Internal): 78/329, 23.56% (2021 JCR).
12. Tai-Jay Chang*, De-Ming Yang, Mong-Lien Wang, Kung-How Liang, Ping-Hsing Tsai, Shih-Hwa Chiou, Ta-Hsien Lin, Chin-Tien Wang, "Genomic analysis and comparative multiple sequences of SARS-CoV2", 2020, Journal of the Chinese Medical Association, 83, 537-543. IF: 3.396, 5 yr IF: 3.046, Ranking (Medicine, General& Internal): 78/329, 23.56% (2021 JCR).
13. Kung-Hao Liang, Tai-Jay Chang, Mong-Lien Wang, Ping-Hsing Tsai, Ta-Hsien Lin, Chin-Tien Wang, De-Ming Yang*, "Novel biosensor platforms for the detection of coronavirus infection and severe acute respiratory syndrome coronavirus 2", 2020, Journal of the Chinese Medical Association, 83, 701-703. IF: 3.396, 5 yr IF: 3.046, Ranking (Medicine, General& Internal): 78/329, 23.56% (2021 JCR).
14. Ping-Hsing Tsai, Mong-Lien Wang, De-Ming Yang, Kung-How Liang, Shih-Jie Chou, Shih-Hwa Chiou, Ta-Hsien Lin, Chin-Tien Wang, Tai-Jay Chang*, "Genomic variance of Open Reading Frames (ORFs) and Spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)", 2020, Journal of the Chinese Medical Association, 83, 725-732. IF: 3.396, 5 yr IF: 3.046, Ranking (Medicine, General& Internal): 78/329, 23.56% (2021 JCR).
15. Chu-Ting Liang, Yu-Shan Lin, Yi-Choang Huang, Hsien-Lu Huang, Jia-Qian Yang, Tsung-Hsien Wu, Chi-Fon Chang, Shing-Jong Huang, Hsien-Bin Huang*, Ta-Hsien Lin*, "Characterization of the interactions between inhibitor-1 and recombinant PP1 by NMR spectroscopy", 2018, Scientific Reports, 8, Article number:50, IF: 4.996, 5 yr IF: 5.516, Ranking (Multidisciplinary Sciences): 19/79, 25.34% (2021 JCR).
16. Su-Chun How, Yu-Hong Cheng, Chun-Hsien Lo, Jinn-Tsyy Lai, Ta-Hsien Lin, Zuzana Bednarikova, Andrea Antosova, Zuzana Gazova*, Josephine W.Wu**, Steven S.-S. Wang***, "Exploring the effects of methylene blue on amyloid fibrillogenesis of lysozyme", 2018, International Journal of Biological Macromolecules, 119, 1059–1067. IF: 8.025, 5 yr IF: 7.626, Ranking (Polymer Science): 6/90, 6.11% (2021 JCR).
17. Chun-Tien Kuo, Yi-Lin Chen, Wei-Tse Hsu, Su-Chun How, Yu-Hong Cheng, Shu-Shun Hsueh, Hwai-Shen Liu, Ta-Hsien Lin, Josephine W. Wu*, Steven S.-S. Wang*, "Investigating the effects of erythrosine B on amyloid fibril formationderived from lysozyme", 2017, International Journal of Biological Macromolecules, 98, 159-168. IF: 8.025, 5 yr IF: 7.626, Ranking (Polymer Science): 6/90, 6.11% (2021 JCR).
18. Chu-Ting Liang, Hsien-Bin Huang, Chih-Ching Wang, Yi-Ru Chen, Chi- Fon Chang, Ming-Shi Shiao, Yi-Cheng Chen*, Ta-Hsien Lin*, "L17A/F19A Substitutions Augment the α-Helicity of β-Amyloid Peptide Discordant Segment", 2016, PLOS ONE, 11, e0154327. IF: 3.752, 5 yr IF: 4.069, Ranking (Multidisciplinary Sciences): 29/73, 39.04% (2021 JCR).
19. Chi-Jen Lo, Chih-Ching Wang, Hsien-bin Huang, Chi-Fon Chang, Ming-Shi Shiao, Yi-Cheng Chen*, Ta-Hsien Lin*, "Arctic mutation accelerates Aβ aggregation in SDS through reducing the helical propensity of residues 15-25", 2015, Amyloid, 22, 8-18. IF: 6.571 5 yr IF: 6.770, Ranking (Medicine, General & Internal): 29/172=16.57% (2021 JCR).