TEL: 02-2871-2121#24350

E-mail: cychen58@vghtpe.gov.tw

2011   美國愛荷華州立大學學士

2015   美國伊利諾大學香檳分校博士

2020   美國西北太平洋研究中心博士後研究員

1. 腦神經發育
2. 基因調控
3. 單細胞基因定序
4. 空間轉錄體

國科會

院內計畫

1. 2025/01 榮總陽交大雙邊合作會議
Title: Transcriptional Analysis: From Cells to Disease Treatment

2. 2024/12 世基認10你真好系列講座
Title: Single-cell and spatiotemporal transcriptomics reveal pathomechanisms for XLRS using RS1 knock-in mice

3. 2023/11 10x Genomics 空間體學應用經驗分享會
Title: Exploration of retia research using Xenium

1.  Yuen Chien, You-Ren Wu, Chih-Ying Chen, Yi-Ping Yang, Lo-Jei Ching, Bo-Xuan Wang, Wei-Chao Chang, I-Hsun Chiang, Pong Su, Shih-Yu Chen, Wen-Chang Lin, I- Chieh Wang, Tai-Chi Lin, Shih-Jen Chen, Shih-Hwa Chiou*, 2024. Identifying Multiomic Signature of X-linked Retinoschisis-Derived Retinal Organoids and Mice Harboring Patient-Specific Mutation Using Spatiotemporal Single-Cell

Transcriptomics. Adv Sci. e2405818. 本人為共同第一作者.

2.  Shih-Yuan Peng, Chih-Ying Chen, Hsin Chen, Yi-Ping Yang, Mong-Lien Wang, Fu- Ting Tsai, Chian-Shiu Chien, Pei-Yu Weng, En-Tung Tsai, I-Chieh Wang, Chih-Chien Hsu, Tai-Chi Lin, De-Kuang Hwang, Shih-Jen Chen, Shih-Hwa Chiou*, Chuan-Chih Chiao*, Yuen Chien*, 2024. Inhibition of angiogenesis by the secretome from iPSC- derived retinal ganglion cells with Leber’s herefitary optic neuropathy-like phenotypes.

Biomed Pharmacother. 178:117270. 本人為共同第一作者.

3.  La’ah, AS., Tsai, PH., Yarmishyn, AA., Ching, LJ., Chen, CC., et al, 2024 Neutrophils recruited by NKX2-1 suppression via activation of CXCLs/CXCR2 axis promote lung adenocarcinoma progression. Adv Sci, 11(38):e2400370.

4.  Chou, S.J., Yang, Y.P., Chiang, M.R., Chen, C.C., Lai, H.I.A.M. et al., 2024 Ophthalmic Tethered Gold Yarnball-Mediated Retained Drug Delivery for Eye Fundus Disease Treatment. Small Science, 4(8): 2400095.

5.  Jia-Wei She, Chia-Mei Young, Shih-Jie Chou, You-Ren Wu, Yu-Ting Lin, Tzu-Yang Huang, Mo-Yuan Shen, Chih-Ying Chen, Yi-Ping Yang, Yuen Chien, Hailemichael Ayaleu, Wei-Hao Liao, Yi-Chung Tung, Jing-Jong Shyue, Shih-Hwa Chiou, Hsiao- Hua Yu, 2024. Gradient conducting polymer surfaces with netrin-1-conjugation promote axon guidance and neuron transmission of human iPSC-derived retinal ganglion cells. Biomaterials, 313:122770.

6.  Yunshu Song, Christopher H Seward, Chih-Ying Chen, Amber LeBlanc, Analise M Leddy, Lisa Stubbs, 2024. Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin-lineage cells, generates a specific suite of brain, behavioral and molecular pathologies. Genetics, 226(1).

7.  Chen, Chih-Ying, Seward, Christopher H., Song, Yunshu et al., 2022 Galnt17 loss- of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology. Developmental Biology. 490:155-

171. 本人為第一作者.