Assistant Research Fellow at the Department of Medical Research, Taipei Veterans General Hospital
Adjunct Assistant Professor at the Institute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University

1. The impact of the tumor microenvironment on the interaction between tumor cells and immune cells
2. The mechanisms and inhibition of cancer cell drug resistance, invasion, and metastasis.
3. Studying the early stages of carcinogenesis and the interaction between tumors and normal tissues using a 3D lung organ model.

 Funding Source: MOST

1. Dissecting the roles and underlying mechanisms of NKX2.1 in controlling lung cancer drug resistance and shaping tumor (MOST 110-2320-B-075 -006 -MY3. 3-year project)
2. Investigation of the functional and mechanism involvement of YTHDF3 RNA binding protein in the 3rd generation EGFR-TKI resistance of lung cancer. (MOST 109-2320-B-075-001)
3. Investigation of the EGFR/MSI Crosstalk-mediated Chemotherapeutic Resistance and Immune Modulation in Lung Adenocarcinoma (MOST 106-2320-B-075-002)

Funding Source: TVGH

1. Establishing an Integration Platform of Multicenter Biobanksin Veterans General Hospitals (110VACS-008, 111VACS-008)
2. Investigation of the Roles of CXCL5 in the interaction between immune cells and Osimertinib Resistant Lung Adenocarcinoma Cells
3. Establishment of an Artificial Intelligence Platform to Interpret the Drug Resistant Variants of Lung Cancer Cells (V110C-157)
4. Investigation of the Environmental Low-dose Nicotine in the Regulation of Lung Adenocarcinoma Progression (V109E-007-4, V111E-001-4, V112E-002-4)

Funding source: Yen Tjing Ling Medical Foundation

The Outstanding Academic Award from Taipei Veterans General Hospital, Taiwan, 2022

專利名稱：METHOD FOR BLOCKING STRESSINDUCED TUMOR PROGRESSION

國別：USA

Joint Scientific Meeting 2022 on Stem Cell and Cancer Research in Malaysia, 2022

Invited speaker

Title: Regulation of Lung Adenocarcinoma Progression by Circular RNAs – a Novel Insight in Tackling with Lung Cancer.

CCR-CSCR International Webinar Series (1/2022) on Lung Cancer in Malaysia, 2022

Invited speaker

Title: Oncogenic role of circular RNAs in non-small cell lung cancer via EGFR signaling.

2020 International Conference on Translational Medicine and Advanced Therapeutic Medicine in Taipei, 2020.

Section modulator and invited speaker

Title: Novel insight in the Environmental Low-dose Nicotine-induced Lung Cancer Progression.

International Conference of Translational Medicine and Advanced Therapeutics in Taipei, 2019.

Invited speaker

Title: Crosstalk between cancer cells and environmental stimuli.

TVGH-NYMU Joint Matchmaking Press Conference in Taipei, 2019.

Invited speaker by GLORIA, National Yang Ming University

1. Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis. Yarmishyn AA, Ishola AA, Chen CY, Verusingam ND, Rengganaten V, Mustapha HA, Chuang HK, Teng YC, Phung VL, Hsu PK, Lin WC, Ma HI, Chiou SH, Wang ML^#.Cancers (Basel). 2022 Feb 9;14(4):862. doi: 10.3390/cancers14040862.PMID: 35205610  (corresponding author)
    
2. Strategic Decoy Peptides Interfere with MSI1/AGO2 Interaction to Elicit Tumor Suppression Effects. Yang YP, Lee AC, Lin LT, Chen YW, Huang PI, Ma HI, Chen YC, Lo WL, Lan YT, Fang WL, Wang CY, Liu YY, Hsu PK, Lin WC, Li CP, Chen MT, Chien CS, Wang ML^#.Cancers (Basel). 2022 Jan 20;14(3):505. doi: 10.3390/cancers14030505.PMID: 35158774  (corresponding author)
    
3. Oncogenic circRNA C190 Promotes Non-Small Cell Lung Cancer via Modulation of the EGFR/ERK Pathway. Ishola AA, Chien CS, Yang YP, Chien Y, Yarmishyn AA, Tsai PH, Chen JC, Hsu PK, Luo YH, Chen YM, Liang KH, Lan YT, Huo TI, Ma HI, Chen MT, Wang ML^#, Chiou SH. Cancer Res. 2022 Jan 1;82(1):75-89. doi: 10.1158/0008-5472.CAN-21-1473. Epub 2021 Nov 9. PMID: 34753774 (co-corresponding author)
    
4. Deep proteogenomic investigations elucidate the NRF2 antioxidant mechanism as a major driving mechanism of lung adenocarcinoma in Asia. Liang KH, Wang ML^#. J Chin Med Assoc. 2021 Aug 1;84(8):766-771. doi: 10.1097/JCMA.0000000000000577.PMID: 34183593 (corresponding author)
    
5. Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression. Yang YP, Chien CS, Yarmishyn AA, Chan MS, Lee AC, Chen YW, Huang PI, Ma HI, Lo WL, Chien Y, Lin WC, Wang ML^#, Chen MT. Cancers (Basel). 2021 Apr 9;13(8):1799. doi: 10.3390/cancers13081799. PMID: 33918794 (co-corresponding author)
    
6. Generation of Osimertinib-Resistant Cells from EGFR L858R/T790M Mutant NSCLC Cell Line. Verusingam ND, Chen YC, Lin HF, Liu CY, Lee MC, Lu KH, Cheong SK, Ong AH, Chiou SH, Wang ML^#. J Chin Med Assoc. 2021 Mar 1;84(3):248-254. doi: 10.1097/JCMA.0000000000000438. PMID: 33009209 (corresponding author)
    
7. METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium. Chien CS, Li JY, Chien Y, Wang ML, Yarmishyn AA, Tsai PH, Juan CC, Nguyen P, Cheng HM, Huo TI, Chiou SH, Chien S. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2025070118. doi: 10.1073/pnas.2025070118.PMID: 33579825 
    
8. Musashi-1 promotes cancer stem cell properties of glioblastoma cells via upregulation of YTHDF1. Yarmishyn AA, Yang YP, Lu KH, Chen YC, Chien Y, Chou SJ, Tsai PH, Ma HI, Chien CS, Chen MT, Wang ML^#. Cancer Cell Int. 2020 Dec 14;20(1):597. doi: 10.1186/s12935-020-01696-9. PMID: 33317545 (corresponding author) 
    
9. Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung Adenocarcinoma Progression. Wang ML^#, Hsu YF, Liu CH, Kuo YL, Chen YC, Yeh YC, Ho HL, Wu YC, Chou TY, Wu CW. Int J Mol Sci. 2020 Sep 17;21(18):6829. doi: 10.3390/ijms21186829. PMID: 32957649 (1^st author)
    
10. Use of Radiographic Features in COVID-19 Diagnosis: Challenges and Perspectives. Chen SG, Chen JY, Yang YP, Chien CS, Wang ML^#, Lin LT^#. J Chin Med Assoc. 2020 Jul;83(7):644-647. doi: 10.1097/JCMA.0000000000000336. PMID: 32349032 (co-corresponding author)
     
11. Plasma Level of Circular RNA hsa_circ_0000190 Correlates with Tumor Progression and Poor Treatment Response in Advanced Lung Cancers. Luo YH, Yang YP, Chien CS, Yarmishyn AA, Ishola AA, Chien Y, Chen YM, Huang TW, Lee KY, Huang WC, Tsai PH, Lin TW, Chiou SH, Liu CY, Chang CC, Chen MT, Wang ML^#.Cancers (Basel). 2020 Jun 30;12(7):1740. doi: 10.3390/cancers12071740. PMID: 32629833 (corresponding author)
     
12. Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection. Liang Y^#, Wang ML^#, Chien CS, Yarmishyn AA, Yang YP, Lai WY, Luo YH, Lin YT, Chen YJ, Chang PC, Chiou SH. Front Immunol. 2020 May 12;11:1022. doi: 10.3389/fimmu.2020.01022. eCollection 2020. PMID: 32574260 (# equal contribution as 1^st author)
     
13. Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9-Mediated Knockin of Retinoschisin 1 Gene-A Potential Nonviral Therapeutic Solution for X-Linked Juvenile Retinoschisis. Chou SJ, Yang P, Ban Q, Yang YP, Wang ML, Chien CS, Chen SJ, Sun N, Zhu Y, Liu H, Hui W, Lin TC, Wang F, Zhang RY, Nguyen VQ, Liu W, Chen M, Jonas SJ, Weiss PS, Tseng HR, Chiou SH. Adv Sci (Weinh). 2020 Apr 16;7(10):1903432. doi: 10.1002/advs.201903432. eCollection 2020 May. PMID: 32440478
     
14. A Review of SARS-CoV-2 and the Ongoing Clinical Trials. Tu YF, Chien CS, Yarmishyn AA, Lin YY, Luo YH, Lin YT, Lai WY, Yang DM, Chou SJ, Yang YP, Wang ML^#, Chiou SH^#. Int J Mol Sci. 2020 Apr 10;21(7):2657. doi: 10.3390/ijms21072657. PMID: 32290293 (co-corresponding author)
     
15. Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. Chen HY^#, Wang ML^#, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH. Theranostics 2020 Jan; 10(1):201-217. doi:10.7150/thno.35895. PMID: 31903115 (# equal contribution as 1^st author)
     
16. Non-coding RNA and Lung Cancer Progression. Adekunle IA, La'ah AS, Le HD, Viet NQ, Yang YP, Chou SJ, Tai HY, Chien CS, Wang ML^#. J Chin Med Assoc. 2020 Jan;83(1):8-14. doi: 10.1097/JCMA.0000000000000225. PMID: 31770191 (corresponding author)
     
17. Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network. Tsai PH^#, Chien Y^#, Wang ML^#, Hsu CH, Laurent B, Chou SJ, Chang WC, Chien CS, Li HY, Lee HC, Huo TI, Hung JH, Chen CH, Chiou SH. Nucleic Acids Res. 2019 Nov 4;47(19):10115-10133. doi: 10.1093/nar/gkz801. PMID: 31555818 (# equal contribution as 1^st author)
     
18. Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis. Huang KC^#, Wang ML^#, Chen SJ, Kuo JC, Wang WJ, Nhi Nguyen PN, Wahlin KJ, Lu JF, Tran AA, Shi M, Chien Y, Yarmishyn AA, Tsai PH, Yang TC, Jane WN, Chang CC, Peng CH, Schlaeger TM, Chiou SH. Stem Cell Reports. 2019 Nov 12;13(5):906-923. doi: 10.1016/j.stemcr.2019.09.010. Epub 2019 Oct 24. PMID: 31668851 (# equal contribution as 1^st author)
     
19. Tumor Mesenchymal Stromal Cells Regulate Cell Migration of Atypical Teratoid Rhabdoid Tumor through Exosome-Mediated miR155/SMARCA4 Pathway. Yang YP, Nguyen PNN, Ma HI, Ho WJ, Chen YW, Chien Y, Yarmishyn AA, Huang PI, Lo WL, Wang CY, Liu YY, Lee YY, Lin CM, Chen MT, Wang ML^#. Cancers (Basel). 2019 May 24;11(5):720. doi: 10.3390/cancers11050720. PMID: 31137686. (corresponding author)
     
20. Dual Delivery of HNF4α and Cisplatin by Mesoporous Silica Nanoparticles Inhibits Cancer Pluripotency and Tumorigenicity in Hepatoma-Derived CD133-Expressing Stem Cells. Tsai PH^#, Wang ML^#, Chang JH, Yarmishyn AA, Nhi Nguyen PN, Chen W, Chien Y, Huo TI, Mou CY, Chiou SH. ACS Appl Mater Interfaces. 2019 Jun 5;11(22):19808-19818. doi: 10.1021/acsami.9b04474. Epub 2019 May 16. PMID: 31066542 (# equal contribution as 1^st author)