TEL: +886-2-28712121 Ext.3218 E-mail: jcwu@vghtpe.gov.tw
JAW-CHING WU, M.D. Ph.D. 吳肇卿醫學博士
EDUCATION 學位
M.D. 醫學士- Taipei Medical College, 1972-1979 Ph.D. 醫學博士- Institute of Clinical Medicine, National Yang-Ming Medical College, Taipei, 1987-199

PROFESSION專業
Medical Officer醫官, Army of R.O.C., 1979-1981
Resident in Medicine 內科部住院醫師- Taipei Veterans General Hospital, 1981-1984
Research Fellow in Hepatology 胃腸科住院醫師研究員- Taipei Veterans General Hospital, 1984-1986
Attending Physician - Gastroenterology Division 胃腸科主治醫師, Taipei Veterans General Hospital, 1986- 2004
Attending Physician, Department of Medical Research and Education教學研究部主治醫師, Taipei Veterans General Hospital, 2004- 2013.10
Chief, Translational Research Division, Medical Research Department, 醫學研究部轉譯研究科主任Taipei Veterans General Hospital, 2013.10-2017.07
Attending Physician, Medical Research Department, 醫學研究部主治醫師, Taipei Veterans General Hospital, 2013.10-present
Chief, Medical Research Department, 醫學研究部主任Taipei Veterans General Hospital, 2017.07-present
 

ACADEMIC APPOINTMENTS AND SERVICES學術職位與服務
Instructor in Medicine 講師- National Yang-Ming Medical College, Taipei, 1986-1990
Associate Professor in Medicine 副教授- National Yang-Ming Medical College, Taipei, 1990-
Professor in Medicine 內科教授- National Yang-Ming University School of Medicine, 1994- present
Professor of Institute of Clinical Medicine臨床醫學研究所教授, National Yang-Ming University School of Medicine, 1998-present
台北榮民總醫院研究計劃複審委員
國立陽明大學醫學院院評會委員
國立陽明大學研發處委員
Professor and Director of Institute of Clinical Medicine臨床醫學研究所教授兼所長 National Yang-Ming University School of Medicine, 2004-2010 July
Chairman, Academic Committee, Department of Education and Medical Research, Taipei Veterans General Hospital 台北榮民總醫院教學研究部學術委員會主任委員 2005-present
台灣消化系醫學會監事 2006-2008
96-97年度臺北市癌症防治醫療網諮詢委員
2009 APDW at Taipei Deputy President
President, Taiwan Association for the Study of Liver (TASL), 2008-2009
Executive member, Taiwan Association for the Study of Liver (TASL), 2010-present
Board member, Prevention and Treatment Committee for Hepatocellular Carcinoma and Hepatitis.

 

AFFILIATIONS相關醫學會
Society of Internal Medicine, R.O.C.
Society of Medical Ultrasound, R.O.C.
Society of Gastroenterology, R.O.C.
Society of Gastrointestinal endoscopy, R.O.C.
American Association for the Study of Liver Diseases (AASLD)
European Association for the Study of the Liver (EASL)
Asian Pacific Association for the Study of the Liver (APASL)
International Association for the Study of the Liver (IASL)

 

EDITORIAL APPOINTMENTS醫學期刊編審工作
Editorial Board, Chinese Journal of Gastroenterology, 1988-1989
Editorial Board, Journal of Internal Medicine, R.O.C., 1990-3, 1997-
Editorial Board, Chinese Medical Journal (Taipei), 1993-present
Honorary Editor-in-Chief, world Journal of Gastroenterology (2006, 2007-2009, 2010-2013)
Editorial board, Journal of Gastroenterology and Hepatology (2006, 2007-)
Editorial Board, Hepatology International (2007-)
Editorial Board, mSphere (2015-)

 

REVIEWERS (國內外學術期刊與研究審查委員)
Taiwan Journal of Gastroenterology
Journal of Internal Medicine, R.O.C.
Editorial board, Journal of Chinese Medical Association (Chinese Medical Journal, Taipei)
Kaosiung Medical Journal
Journal of Biomedical Science
Gastroenterology
American Journal of Gastroenterology
Journal of Gastroenterology and Hepatology (2001 to 2007-)
Journal of Medical Virology
Journal of Virological Methods
Hepatology
Life Science
Liver Intrnational (2004-2008)
Journal of Molecular Medicine
Electronic Journal of Biotechnology
World Journal of Gastroenterology (2006, 2007-)
Alimentary Pharmacology & Therapeutics (2006-)
International Journal of Cancer (2006-)
Journal of Viral Hepatitis (2006-)
Archives of Virology (2008-)
Journal of Hepatology (2009-)
Clinical Gastroenterology and Hepatolgoy (2007)
Future Microbiology (2009)
Hepatoloy Intrnational (2010)
Journal of Clinical Virology (2009)
National Science Council, R.O.C. 國科會院研究計劃、獎助、會議補助與出國開會審查
Department of Health 衛生署研究計劃與成果報告審查
Department of Education 教育部與各大學教職升等審查
National Health Research Institute 國家衛生研究院
Academic Sinica 中央研究院研究計劃與研究人員評鑑審查
2002-2004 Chairman, Gastroenterology/Hepatology research section of the National Science Council, Taiwan 國科會胃腸學門召集人
2002-2004 國科會內科複審2005-2006
財團法人高等教育評鑑中心基金會系所評鑑醫學學門評鑑委員(2007-)
Reviewer for scholarship to study abroad of the Ministry of Education (2007)教育部96年留學獎學金甄試面試委員

NATIONAL APPOINTMENTS國家任命
Board Member of the prevention and treatment committee for hepatitis and hepatocellular carcinoma, Department of Health, Taiwan台灣衛生署肝炎防治委員會委員
Consultant, Center for Disease Control, Taiwan, 2005-, 疾病管制局諮詢委員

AWARDS服務與學術獎
1980-1981 - Excellent Medical Officer優良醫官(榮獲陸軍總司令獎狀)
1982-1984 - Distinguished Academic Record in Clinical Medicine內科學術考試成績優異, Taipei Veterans General Hospital
1984 - Excellent Clinical Service服務成績優良, Veterans General Hospital, Taipei
1988, 1991 - Academic Prize for Excellent Research, Veterans General Hospital, Taipei. 台北榮民總醫院優秀論文獎
1989 - Distinguished Award for the Mass Screening of Hepatocellular Carcinoma肝癌篩檢傑出獎, the Cancer Society, R.O.C.
1990 - Professor Sung Juei-Low's Academic Prize for Excellent Research
宋瑞樓教授優秀論文獎
1986-1990 - Research Award, National Science Council國科會研究獎, R.O.C.
1991 - Outstanding Research Award, Research, Development and Evaluation Commission, Executive Yuan行政院研考會傑出研究獎, ROC
1991-1992 - Excellent Research Award國科會優等研究獎, National Science Council
1993-1994 - Winner of National Science Council’s (NSC) Outstanding Achievement in Science
and Technology Award國科會傑出研究獎
1995 - Academic Prize for Excellent Research, Veterans General Hospital, Taipei. 台北榮民總醫院優秀論文獎
1995-1996 - Winner of National Science Council’s (NSC) Outstanding Achievement in Science
and Technology Award 國科會傑出研究獎
1996-Outstanding merit and high scholastic achievement to medical and pharmaceutical research
award of Wang Ming-Ning Foundation. 王民寧先生紀念基金會傑出醫藥研究貢獻成就獎
1997-1998 - Winner of National Science Council’s (NSC) Outstanding Achievement in Science
and Technology Award國科會傑出研究獎
1999-2001 - NSC Research Fellow, R.O.C. 國科會特約研究員
1999- Academic Prize for Excellent Research, Veterans General Hospital, Taipei. 台北榮民總醫院優秀論文獎
2000- Academic Prize for the Best Research, Veterans General Hospital, Taipei. 台北榮民總醫院優秀論文獎第一名
1999-2005 – NSC Research Fellow 國科會特約研究員
2005 Outstanding NSC Research Fellow 國科會傑出特約研究員
2006 Outstanding physician, Veterans Affairs Commission, Executive Yuan, ROC 中華民國行政院退除役官兵輔導委員會95年優良醫師
Excellence in format, content and presentation of a poster given at the 21st Joint Annual Conference of Biomedical Sciences
2007 Presidential Award (Masao Omata, President of APASL), 17th Asian Pacific Association for the Study of the Liver Conference, March 27th - 30th 2007, at Kyoto, Japan. 2007年第十七屆亞太肝臟學會會長獎
2009 One of the Important Academic Achievements at the 50th Anniversaries of Taipei Veterans General Hospital 台北榮民總醫院50週年院慶重大學術成就獎
2011 Best poster, Veterans General Hospitals & University System of Taiwan Joint Research Program
2012 Excellent poster, Veterans General Hospitals & University System of Taiwan Joint Research
2007-2016 Distinguished professor, National Yang-Ming University 國立陽明大學特聘教師

PERFORMANCE IN TEACHING教學表現
2001- Professor Sung Juei-Low's Academic Prize for Excellent Research (Ph.D. student Dr. Yi-Hsiang Huang) 宋瑞樓教授優秀論文獎 (博士生黃怡翔)
2007- Professor Sung Juei-Low's Academic Prize for Excellent Research (Ph.D. student Dr. Chien-Wei Su) 宋瑞樓教授優秀論文獎 (博士生蘇建維)
2006 Excellent teaching by a survey through web in National Yang-Ming University 95學年度第一學期醫學系網路教師教學意見調查之優良教師
2008 Best paper of Ph. D. students of the Clinical Medicine Group of National Yang-Ming University 指導博士生施宣輝榮獲國立陽明大學96學年度學術論文研討會研究生組(臨床醫學與公共衛生研究組博士班)優等獎
2009 Excellent teaching by a survey through web in the Institute of Clinical Medicien, National Yang-Ming University國立陽明大學臨床醫學研究所優良教師
2009 Excellent thesis advisor of Institute of Clinical Medicine, National Yang-Ming University優良論文指導老師
2009 Important revolution of systems: postgraduate taining in the Institute of Clincial Medicine. 台北榮民總醫院50週年院慶重要制度興革：協助臨床醫學研究所的發展以培育臨床與轉譯醫學研究的高階人才
2010, 2012-2014 Excellent teaching by a survey through web in National Yang-Ming University
2013 Excellent poster (PhD student Su CW). The Fifth Annual Institutes of Clinical Medicine Joint Research and Teaching Workshop.
2015 Excellent teaching by a survey through web in National Yang-Ming University

FOCUS OF RESEARCH研究重點
Viral Hepatitis and Hepatocellular Carcinoma病毒性肝癌與肝細胞癌

PUBLICATIONS
From 1986 to February 18, 2016 – 330 papers

Major findings and significance of the research works by Jaw-Ching Wu
1. The discovery of major transmission mode of HDV infection and extensive epidemiological study of HDV infection in Taiwan. Hepatitis D virus superinfection is the most important etiology of fulminant hepatitis in Taiwan, an endemic area of HBV infection. A series of papers of HDV infection by me contribute significantly to epidemiological, clinical and virological research of this disease. The findings of the major transmission route of HDV infection in this area (sexual contact with prostitutes), and the subsequent, sustained public education play a significant role in the reduction of HDV infection in this area.
2. Detail clinical and pathogenic studies of HDV infection based on the longitudinal correlation between HBV and HDV replication and clinical course.
3. The establishment of a simple genotyping method using RFLP and type-specific antibodies for hepatitis D virus, which is very useful for global molecular-epidemiological and virologic studies. The original findings of the correlation of hepatitis D virus genotypes with clinical manifestations and virus package .
4. The first report of an in vitro replication and package system of hepatitis D virus. This system contributes to the understanding of the mechanism of hepatitis D virus package.
5. The discovery of a novel hepatitis D virus subtype (genotype IIb) which is a recombinant of genotypes I and II, and proved to be a dominant strain of Okinawa later. This finding has an important implication in the virology and evolution of HDV.
6. The first paper to show that mixed genotypes infection of hepatitis D virus does occur in humans, particularly in high risk groups.
7. The first paper discovers that recombination occurs in a small virus like HDV, and shows the important role of recombination in the evolution and evasion of HDV from immunity.
8. The first paper of DNA-Based Immunization of HDV. The first study of immunogenic domains associated with HDV clearance.
9. The first study of defective HDV and its clinical implications. The discovery of an interesting defective HDV that may have important evolutionary implications.
10. The first paper of the correlation of HDV genotypes with varied viral editing and assembly efficiencies.
11. The original paper studying the impact of HBV and HDV genotypes on the clinical course and outcome of HDV infection.
12. Determination of immunogenic epitopes associated with positive selection of hepatitis delta antigen in chronic hepatitis D patients.
13. Identification of crucial domains of HBV and HDV associated with the assembly of HDV.
14. The discovery of the major transmission route of acute hepatitis B virus infection in adults in Taiwan, and resulted in the extending vaccination to susceptible adults in Taiwan.
15. The first paper to report injection with non-disposable needles as an important route for transmission of acute community-acquired hepatitis C virus infection in Taiwan
16. A series of papers of clinical studies of hepatocellular carcinoma contribute to more understanding about the clinical manifestations, the mass screening and the management of hepatocellular carcinoma.
17. The first one to isolate and sequence HEV from patients in Taiwan. Multivariate analysis of risk factor and phylogenetic analysis of HEV genome indicate that the majority of HEV infection in Taiwan is transmitted from traveling to endemic areas in the world. These findings are of great value in the prevention of the spread of HEV to Taiwan. There are increasing traveling, trading and visiting across different areas of the world. This paper has important implications to public health and emphasizes the impact of travel on the spread of disease.
18. One of the original papers to isolate HEV from swine, which suggests that swine may be a reservoir of HEV. It has an important implication that zoonotic infection may be important in the future. This paper discovers the potential source of endemic infection of HEV.
19. The first paper reports HEV spread across countries through trading of swine and the infection in different-aged swine.
20. The first paper to raise the concern and the warning that Isoniazid-Rifampin induced hepatitis in hepatitis B carriers may be more often associated with severe outcome.

吳肇卿教授主要的研究發現如下：

1、 Ｄ型肝炎曾是臺灣及世界上重要的猛爆性肝炎病因之一。首先發現台灣地區Ｄ型肝炎病毒最常見的傳染途徑來自於和娼妓發生性行為。透過大眾傳播媒介及醫學會長期與廣泛的宣導，促成急性Ｄ型肝炎與其相關的猛爆性肝炎顯著減少。
2. Ｄ型肝炎的自然病史研究：B與Ｄ型肝炎病毒基因型及複製在不同感染時期對Ｄ型肝炎病程的影響，是有關Ｄ型肝炎自然病史與致病機轉最完整的縱向研究。
3. 首先發展簡易的鑑定Ｄ型肝炎病毒基因型的方法，對台灣地區與全球Ｄ型肝炎分子流行病學與自然病史的研究有極大的助益。首度發現並探討Ｄ型肝炎病毒基因型影響病毒的裝配速率與臨床病程。
4. 發現Ｄ型及B型肝炎病毒基互相作用與病毒裝配的重要區域及氨基酸，這項發現也釐清了不同基因型Ｄ型肝炎病毒的全球流行病學的病毒學機轉。
5. 建立了第一個體外的Ｄ型肝炎病毒複製與裝配系統，這個系統廣泛的為世界上的肝病學者應用，對Ｄ型肝炎病毒裝配機轉的研究有極大的幫助。
6. 首先發現並分離D型肝炎病毒第4型，此型在病毒演化與分子流行病學上具獨特的角色，也促成D型肝炎病毒基因重組的發現。首度證明Ｄ型肝炎病毒基因型混合感染的存在，尤其是高危險?。首度證明Ｄ型肝炎病毒這麼小的病毒也可發生基因重組，及其免疫逃脫與演化上的意義。
7. 首先發現Ｄ型肝炎毒殺T細胞的免疫辨識區，這些區域和病毒的清除與免疫逃脫密切相關，領先發表Ｄ型肝炎病毒的基因疫苗，對Ｄ型肝炎的預防與治療提供一個具潛力的研究方向。鑑定慢性Ｄ型肝炎病人Ｄ型肝炎病毒株選擇的免疫辨識區，對疫苗的研發有助益。
8. 首先發現台灣成人的急性Ｂ型肝炎最常見的傳染途徑是性行為，並透過大眾傳播媒介及醫學會長期與廣泛的宣導，有助於成人急性Ｂ型肝炎的防治。
9. 首先發現台灣地區E型肝炎主要傳染途徑為境外移入，並首度分離、序列分析台灣病人的E型肝炎病毒。
10. 全球第二位從豬中分離、序列分析E型肝炎病毒，並證明其與人的E型肝炎病毒基因序列的高度近似性。提出重要的警語「旅行與物種交叉感染可成為未來疾病傳播的重要方式」。
11. 首先發現並提出警語指出慢性Ｂ型肝炎帶原者接受Isoniazid-Rifampin 治療肺結核引起的肝炎較非慢性Ｂ型肝炎帶原者嚴重甚至危及生命。
12. 發現肝癌手術後的早期復發與Twist, Snail表現誘發的表皮細胞間質化(Epithelial-Mesenchymal-Transition, EMT)有關， Twist, Snail獨立且加乘的促進肝癌的轉移及復發。C型肝炎引起的肝癌手術後較高的早期復發則與癌組織表現較高的Twist有關。本篇文章發表於肝臟學領域的領導期刊(Hepatology 2009;50:1464-1474. IF: 11.355, 2/55，With an editorial. selected to take part in the article-level PR program for the journal Hepatology) 晚期復發則是新生第二個原發肝癌，和病毒濃度及非癌肝組織的發炎活性相關，本篇文章發表於肝臟學領域的一流期刊(J Hepatol 2009;51:890-7. IF: 7.056, 5/55，With an editorial)，目前已將之轉譯為多中心臨床試驗。兩篇文章均獲該期期刊社論特別評介。這一系列的發現對治療或預防肝癌手術後的復發將有較全貌的策略及幫助

研究結合臨床、流行病學與分子生物學的方法，探討病毒性肝炎與肝細胞癌這個重要的問題，是結合臨床與基礎的「轉譯醫學」研究。系列原創論文發表於Lancet, Gastroenterology, Hepatology, Journal of Virology, Journal of Infectious Disease, Molecular Biology and Evolution等ㄧ流的學術期刊，並經常被相關的國際學者引用(10篇最常被引用的論文平均被引用81次)，多篇獲社論或重點介紹，且被「專家綜論」列為參考文獻，四十六篇病毒性肝研或肝癌的原創論文曾被五十一本以上的國際肝臟疾病相關的專書列為參考文獻，並為另三本教科書撰寫三個章節。

>Forty-six papers have been cited by books (based on hard copies and/or Google search),

1. Sherlock’s “Diseases of the liver and biliary system”,

2. Benhamou’s “ Oxford’s textbook of Clinical Hepatology”,

3. Arie J Zuckerman and Howard C Thomas eds: “Viral Hepatitis”,

4. F. Blaine Hollinger, Robert H Purcell, John L Gerin, Donald E Ganem, Stephen M Feinstone, Suzanne U Emerson, Marian E Major, Robert J Schneider, J Jake Liang, John L Casey, Barbara Rehermann eds. “Viral Hepatitis”, 5. Zakim & Boyer eds: “Hepatology: a textbook of liver disease”,

6. Eugene R Schiff, Michael F Sorrell, Willis C Maddrey eds. “Diseases of the Liver”,

7. Sleisenger & Fordtran’s Gastroenterology and Liver Disease. Pathophysiology/Diagnosis/Management. Sabiston’s Textbook of Surgery. The Biological Basis of Modern Surgical Practice.

8. Meng XJ (2005). Hepatitis E as a zoonosis. Viral Hepatitis, 3rd edition, Edited by H. Thomas, A. Zuckermann, and S. Lemon. pp611-623. Blackwell Publishing Ltd, Oxford, U.K.

9. Karayiannis P, Thomas HC. Hepatitis vaccine. Brit Med Bull 2004;70:29-49.

10. Handa H, Yamaguchi Y eds. “Hepatitis Delta Virus” by Landes Bioscience. 2006.

11. Casey JL ed. “Hepatitis delta virus”. Current Topics in Microbiology and Immunology. 2006;307:173-186.

12. Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen and Mario Rizzetto eds: The Textbook of Hepatology: From Basic Science to Clinical Practices. 3rd edition, 2007.

13. Purdy, Michael A. "Phylogenetics and Medicinal Protein Engineering." Medicinal Protein Engineering. Ed. Yury E. Khudyakov. Boca Raton: Taylor & Francis, 2008: 63. 14. John L Casey ed. “Hepatitis Delta Virus” by Springer. 2007.

15. Wu JC.* Hepatitis D virus and hepatocellular carcinoma. In: Chen DS eds. “Hepatitis Viruses and Hepatocellular Carcinoma.” By Published by World Scientific Publishing Company New Jersey, London, Singapore. 2009.

16. Kaplowitz N et al. eds. “Drug-induced liver disease”;

17. “Abstracts on Hygiene and communicable diseases” Great Britain Bureau of Hygiene and Tropical Diseases;

18. “Tuberculosis and non-tuberculosis Mycobacterial infections”;

19. “A complete therapeutic companion to Sleisenger & Fordtran's GASTROINTESTINAL & LIVER DISEASES.”;

20. “J Pneumol”

21. Herbert E. Spiegel “Advances in Clinical Chemistry”,

22. Seymour Stanton Block “Disinfeciton, sterilization and preservation”,

23. Albert Balows et al. “Laboratory diagnosis of Infectious Diseases”,

24. Douglas D. Richman,Richard J. Whitley,Frederick G. Hayden “Clinical Virology”

25. Gwendolyn L. Gilbert “Infectious Diseases in Pregnancy and the new born infants”.

26. Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri “Liver disease in childeren”.

27. Robert B. Wallace et al. “Wallace/Maxcy-Rosenau-Last public health & preventive medicine”

28. Howard Thomas “Viral Hepatitis”

29. Andrew Friede et al. “CDC prevention guidelines: guideline for action”

30. Inc Icon Group International “Virology: Webster’s Facts and Phrases”

31. G. H. Millward-Sadler,R. Wright,M. J. P. Arthur “Wright’s Liver and Biliary disease: pahthophysiology, diagnosis and management”.

32. Thierry Poynard “Hepatitis B and C: management and treatment

33. E. Jan Irvine,Richard H. Hunt “Evidence-based Gastroenterology”

34. David Kelsen,John M. Daly,Scott E. Kern,Bernard Levin,Joel E. Tepper “principles and practice of gastrointestinal oncology”

35. Alicia P. Willis “Hepatitis B research advances”

36. Melissa Palmer “Doctor Melissa Palmer’s guide to hepatitis & liver diseases”

37. Shabbir Simjee “Foodborne diseases”

38. Pina M. Fratamico,Arun K. Bhunia,James L. Smith “Foodborne pathogens: microbiology and molecular biology”

39. Patrick Marcellin,Tarik Asselah “Hepatites Virales”

40. Klaus-Peter Maier “Prophylaxe der Virus hepatiden”

41. Erwin Kuntz,Hans-Dieter Kuntz “Hepatology: principles and practice”

42. Donald P. Levine,Jack D. Sobel “Infections in intravenous drug abusers”

43. Toshio Shikata,Robert H. Purcell,Toshikazu Uchida “Hepatitis C, D and E”

44. William S. Haubrich,Fenton Schaffner,Henry L. Bockus,Jack Edward Berk :Bockus Gastroenterology: Liver”

45. Association of Clinical Biochemists “Current advances in clinical chemistry”,

46. Stanford W. Ting,Jui-San Chen,Morton K. Schwartz “Human tumor markers”

47. Greet van den Berghe “Acute endocrinology: from cause to consequence”

48. W. Y. Lau “Hepatocellular carcinoma”

49. Arie Belldegrun,Roger S. Kirby,Donald W. W. Newling “New perspectives in prostate cancer”

50. Philip E. Cryer “Hypoglycemia: pathophysiology, diagnosis, and treatment”

51. M. Pombo Arias “Tratado de endocrinolgia pediatrica”

Chapters:

1. Wu JC.* Diagnosis of hepatitis D virus infection. In: Handa H, Yamaguchi Y eds. “Hepatitis Delta Virus” by Landes Bioscience. 2006.

2. Wu JC.* Functional and clinical significance of hepatitis delta virus genotype II infection. Current Topics in Microbiology and Immunology. 2006;307:173-186. John L Casey ed. “Hepatitis Delta Virus” by Springer. 2007.

3. Wu JC.* Hepatitis D virus and hepatocellular carcinoma. In: Chen DS eds. “Hepatitis Viruses and Hepatocellular Carcinoma.” By Published by
World Scientific Publishing Company New Jersey, London, Singapore. 2010.

 

《近期研究著作 2010~ 》

1. Shih HH, Shih C, Wang HW, Su CW, Sheen IJ, Wu JC*. Pro-205 of large hepatitis delta antigen and Pro-62 of major hepatitis B surface antigen influence the assembly of different genotypes of hepatitis D virus. J Gen. Virol 2010;91:1004-1012. 5 citations. Cited by Hepatitis: New Insights for the Healthcare Professional: 2011 Edition, Howard C. Thomas，Anna S. F. Lok，Stephen A. Locarnini，Arie J. Zuckerman. Viral Hepatitis 2013

2. Chen SP, Fuh JL, Wang SJ, Chang FC, Ling JF, Fang YC, Shiau BC, Wu JC. Magnetic Resonance Angiography in Reversible Cerebral Vasoconstriction Syndromes. Ann Neurol 2010;67(5):648-56. 60 citations.

3. Hung HH, Su CW, Lai CR, Chau GY, Huang YH, Huo TI, Lee PC, Kao WY, Lee SD, Wu JC*. Fibrosis and AST to Platelet Ratio Index Predict Prognosis for Solitary Small Hepatitis-B Related Hepatocellular Carcinoma. Hepatology Int 2010;4:691-9. (SCI). 11 citations

4. Hung HH, Chiou YY, Hsia CY, Su CW, Chou YH, Chiang JH, Kao WY, Huo TI, Huang YH, Su YH, Lin HC, Lee SD, Wu JC*. Survival Rates Are Comparable Following Radiofrequency Ablation or Surgery in Patients with Small Hepatocellular Carcinomas. Clin Gastrolenterol Hepatol 2011;9:79-86. 51 citations

5. Kao WY, Su CW, Chau GY, Lui WY, Wu CW, Wu JC*. A Comparison of Prognosis between Patients with Hepatitis B and C Virus-Related Hepatocellular Carcinoma undergoing Resection Surgery. World J Surg 2011;35:858-867. 22 citations

6. Kao WY, Chiou YY, Hung HH, Chou YH, Su CW, Wu JC, Huo TI, Huang YH, Lin HC, Lee SD. Risk factors for long-term prognosis in hepatocellular carcinoma after radiofrequency ablation: their clinical implication of aspartate aminotransferase–platelet ratio index. Eur J Gastroenterol Hepatol 2011;23:528-536. 8 citations.

7. Lee IC, Chan CC, Huang YH, Huo TI, Chu CJ, Lai CR, Lee PC, Su CW, Hung HH, Wu JC, Lin HC, Lee SD. Comparative Analysis of Noninvasive Models to Predict Early Liver Fibrosis in Hepatitis B e Antigen-negative Chronic Hepatitis B. J Clin Gastroenterol. 2011;45(3):278-85. 8 citations

8. Su CW, Lei HJ, Chau GY, Hung HH, Wu JC, Hsia CY, Lui WY, Su YH, Wu CW, Lee SD. The Impact of Age on the Long-Term Prognosis of Patients with Hepatocellular Carcinoma after Resection Surgery: A Propensity Score Matching Analysis. Arch Surg 2012; 147:137-144. 11 citations.

9. Chen CC, Chang CM, Sun CP, Yu CP, Wu PY, Jeng KS, Hu CP, Chen PJ, Wu JC, Shih CH, Gershwin ME, Tao MH. Use of RNA interference to modulate liver adenoma development in a murine model transgenic for hepatitis B virus. Gene Therapy 2012;19:25–33. 6 citations

10. Shih HH, Sheen IJ, Su CW, Peng WL, Lin LH, Wu JC*. Hepatitis D Virus Isolates with Low Replication and Epithelial-Mesenchymal Transition-Inducing Activity are associated with Disease Remission. J Virol 2012;86:9044-9054. 3 citations, cited by Advances in RNA Research and Application: 2013 Edition

11. Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, Hsu MT, Wu JC, Huang HD,, Shiao MS, Hsiao M, Tsou AP. MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest 2012;122(8):2884–2897. 154 citations.

12. Kao WY, Hwang CY, Chang YT, Su CW*, Hou MC, Lin HC, Lee FY, Lee SD, Wu JC. Cancer risk in patients with pyogenic liver abscess: a nationwide cohort study. Aliment Pharmacol Ther 2012; 36:467-476 (SCI, IF: 3.769). 13 citations

13. Su CW, Chiou YW, Tsai YH, Teng RD, Chau GY, Lei HJ, Hung HH, Huo TI, Wu JC*. The influence of Hepatitis B Viral Load and Pre-S Deletion Mutations on Post-operative Recurrence of Hepatocellular Carcinoma and the Tertiary Preventive Effects by Anti-viral Therapy. PLoS One 2013 June 21;8(6):e66457. 9 citation

14. Su CW, Wu CY, Hung HH, Wu CH, Sheen IJ, Wu JC*. Differential roles of serum HBV DNA and HBsAg level in predicting virological breakthrough in patients receiving lamivudine therapy. J Gastroenterol Hepatol 2013;28:1849-1858. 2 citations.

15. Cheng YL, Wang YJ, Kao YW, Ping-Hsien Chen PH, Huo TI, Huang YH, Lan KH, Su CW*, Chan WL, Lin HC, Lee FY, Wu JC*. Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease: A Large-Scale Study in Populations Seeking for Check-Up. PLOS ONE 2013;8:e72049.

16. Wang HW, Hsieh TH Huang SY, Chau GY, Tung CY, Su CW, Jaw-Ching Wu JC*. Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC. BMC Genomics 2013;14:736.

17. Wu CY, Lin JT*, Ho HJ, Su CW, Lee TY, Wang SY, Wu C, Wu JC*. Association of Nucleos(t)ide Analogue Therapy with Reduced Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B—a Nationwide Cohort Study. Gastroenterology 2014;147:143–151 (IF: 13.926, 1/75). 11 citations. With an editorial and covering the cover synopsis. 8 citations.

18. Su CW, Chau GY, Hung HH, Yeh YC, Lei HJ, Hsia CY, Lai CR, Lin HC, Wu JC*. Impact of Steatosis on Prognosis of Patients with Early-Stage Hepatocellular Carcinoma After Hepatic Resection. Ann Surg Oncol. 2014 Dec 10.Ann Surg Oncol. 2014; DOI 10.1245/s10434-014-4221-5 (IF:3.943, 13/204).

19. Hung HH, Chao Y, Chiou YY, Li CP, Lee RC, Huo TI, Huang YH, Chau GY, Su CW*, Yeh YC, Lin HC, Lee SD, Wu JC*. A comparison of clinical manifestations and prognoses between patients with hepatocellular carcinoma and Child-Pugh scores of 5 or 6. Medicine 2014 Dec;93(29):e348 (SCI, IF: 4.867).

20.Wu WC, Su CW, Yang JY, Lin SF, Chen JY, Wu JC*. Application of Serologic Assays For Diagnosing Acute Hepatitis E in National surveillance of a Non-endemic Area. J Med Virol 2014; 86:720–728. 5 citations

21.Wu CY, Lin JT*, Ho HJ, Su CW, Lee TY, Wang SY, Wu C, Wu JC*. Association of Nucleos(t)ide Analogue Therapy with Reduced Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B—a Nationwide Cohort Study. Gastroenterology 2014;147:143–151. With an editorial and covering the cover synopsis. 53 citations.

22.Lee CJ, Yue CH, Lin YY, Wu JC*, Liu JY*. Antitumor Activity of acriflavine in human hepatocellular carcinoma cells. Anticancer Res 2014;34: 3549-3556.

23. Cheng CY, Yang AC, Huang CC, Liu ME, Liou YJ, Wu JC, Tsai SJ, Lin CP, Hong CJ.  The association of RAB18 gene polymorphism (rs3765133) with cerebellar volume in healthy adults. Cerebellum. 2014 Oct;13(5):616-22.

24.Tsao YC, Chung CP, Hsu HY, Cheng CY, Chao AC, Sheng WY, Hu HH, Hong CJ, Wu JC. Collapsed Jugular Vein and abnormal cerebral blood flow changes in patients of Panic Disorder. J Psychiatr Res. 2014 Nov;58:155-60.

25.Chuang CL, Huang HC, Chang CC, Lee FY, Wu JC, Lee JY, Hsieh HG, Lee SD. Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats. J Gastroenterol Hepatol. 2015 Jan;30(1):199-207.

26.Chen CL, Wu JC, Chen GY, Yuan PH, Tseng YW, Li KC, Shiaw-Min Hwang SM,  Hu YC. Baculovirus-mediated miRNA Regulation to Suppress Hepatocellular Carcinoma Tumorigenicity and Metastasis. Molecular therapy 2015 Jan;23(1):79-88.

27.Cheng YL, Wang YC, Lan KH, Huo TI, Huang YH, Su CW, Lin HC, Lee FY, Wu JC, Lee SD. Anti-hepatitis C virus seropositivity is not associated with metabolic syndrome irrespective of age, gender and fibrosis. Ann Hepatol 2015 Mar-Apr;14(2):181-9.

28.Chen CL, Tseng YW, Wu JC, Chen GY, Lin KC, Hwang SM, Hu YC. Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation. Biomaterials 2015;44:71-81.

29.Yang BL, Wu WC, Fang KC, Wang YC, Huo TI, Huang YH, Yang HI, Su CW, Lin HC, Lee FY, Wu JC, Lee SD. External Validation of fatty liver for identifying ultrasonographic fatty liver in a large-scale cross-setional sectional study in Taiwan. PLOS ONE 2015;10(3): e0120443.

30.Wang YF, Fu JL, Lirng JF, Chen SP, Hseu SS, Wu JC, Wang SJ. Cerebrospinal fluid leakage and headache after lumbar puncture: A prospective, non-invasive imaging study. Brain 2015 Jun;138(Pt 6):1492-8.

31.Cheng CY, Wu JC, Tsai JW, Nian FS, Pei-Chun Wu PC, Kao LS, Fann MJ, Tsai SJ, Liou YJ, Tai CY, Chen-Jee Hong CJ. ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18. Experimental Neurology 2015 May;267:143-51.

32.Kao WY, Chao Y, Chang CC, Li CP, Su CW, Huo TI, Huang YH, Chang YJ, Lin HC, Wu JC*. Prognosis of Early-Stage Hepatocellular Carcinoma: The Clinical Implications of Substages of Barcelona Clinic Liver Cancer System Based on a Cohort of 1265 Patients. Medicine 2015;94:e1929.

33.Chen DS, Liaw YF, Chen CJ, Wu JC, Chuang WL, Peng CY, Chien RN. Differences in Hepatitis Viral Etiology of Hepatocellular Carcinoma in Taiwan and China. Hepatology 2015 (letter, accepted).

34.Chong LW, Hsu YC, Lin Y, Chiu YT, Yang, KC, Wu JC, Huang YT. Fluvastatin attenuates hepatic steatosis-induced fibrogenesis in rats through inhibiting paracrine effect of hepatocyte on hepatic stellate cells. BMC Gastroenterol 2015; 15:22.

35.Yang BL, Wu WC, Su CW, Wu JC, Yeh C, Lee SD. Healthy Chinese with benign pancreatic hyperenzymemia. J Chin Med Assoc. 2015;78(10):623-6.