2002 ~2008    Ph.D., National Defense Medical Center, Graduate Institute of life science; National Institute of Cancer Research, National Health Research Institutes

2008 ~ 2011    Postdoctoral Fellow, Stem Cell program, Genomics Research Center, Academia Sinica 

2011 ~ 2013   Postdoctoral Fellow, Departments of Pathology and Global Health, University of Washington, USA 

2013 ~ 2017    Assistant Research Fellow, Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital

(1) The role of glycoproteins and glycoproteins in stem cell differentiation
(2) Application of glycoproteins and glycoproteins in the diagnosis and treatment of cancer
(3) Developing diagnostic or immunotherapeutic targets for liver cancer based on the abnormal expression of glycolipids

SELECTED PUBLICATIONS

1. Wang SY, Huang YH, Liang YJ, Wu JC. Gene Co-Expression Network Analysis Identifies Hubs in Hepatitis B Virus-Associated Hepatocellular Carcinoma. J Chin Med Assoc. 2022 Oct 1;85(10):972-980.

2. Chang YS, Su CW, Chen SC, Chen YY, Liang YJ, Wu JC*. Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance. Cells. 2022 Feb 11;11(4):634.

3. Liang YJ*. Glycosphingolipids in human embryonic stem cells and breast cancer stem cells, and potential cancer therapy strategies based on their structures and functions. Glycoconj J. 2022 Apr;39(2):177-195.

4. Liang, YJ, Teng W, Chen CL, Sun CP, Teng RD, Huang YH, Liang KH, Chen YW, Lin CC, Su CW, Tao MH, Wu JC. Clinical implications on HBV preS/S mutations and the effects of preS2 deletion on mitochondria, liver fibrosis, and cancer development. 2021 Aug;74(2):641-655.

5. Liang, YJ, Cheng-Pu Sun, Chien-Wen Pu, Yu-Chen Hsu, I-An Wang, Yi-Wen Chen, Chien-Wei Su, Mi-Hua Tao, Jaw-Ching Wu*. Statin inhibits large hepatitis delta antigen-Smad3 -twist-mediated epithelial-to-mesenchymal transition and hepatitis D virus secretion. J Biomed Sci. 2020 May 21;27(1):65.

6. Shen-Yung Wang, Chih-Li Chen, Yu-Chen Hu, Yi Chi, Yen-Hua Huang, Chien-Wei Su, Wen-Juei Jeng, Liang, YJ, Jaw-Ching Wu*. High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger Patients. Cancers (Basel). 2019 Oct 13;11(10):1549.

7. Cheng KC, Lin RJ, Cheng JY, Wang SH, Yu JC, Wu JC, Liang YJ, Hsu HM, Yu J, Yu AL. FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. EBioMedicine. 2019 Jul;45:25-38. 

8. Chen CL, Tsai YS, Huang YH, Liang YJ, Sun YY, Su CW, Chau GY, Yeh YC, Chang YS, Hu JT, Wu JC. Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial-Mesenchymal Transition Regulators and Stemness Genes. Hepatol Commun. 2018 Sep 28;2(11):1392-1407.

9. Liang, YJ,*, Chen-Yu Wang, I-An Wang, Yi-Wen Chen, Li-Tzu Li, Chuang-Yu Lin, Ming-Yi Ho, Tsung-Lung Chou, Ya-Hui Wang, Shih-Pin Chiou, Yu-Ju Lin, John Yu*. Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. 2017 Jul 18;8(29):47454-47473.

10. Liang, YJ, Steven B Levery, Marlin Lobaton, Kazuko Handa, Sen-itiroh Hakomori*. Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells. Proc Natl Acad Sci U S A. 2013;110(13):4968-73.

11. Liang, YJ, Bei-Chia Yang, Jin-Mei Chen, Yu-Hsing Lin, Chia-Lin Huang, Yuan-Yuan Cheng, Chi-Yen Hsu, Kay-Hooi Khoo, Chia-Ning Shen, John Yu*. Changes in glycosphingolipid composition during differentiation of human embryonic stem cells to ectodermal or endodermal lineages. Stem Cells. 2011;29(12):1995-2004.

12. Liang, YJ, Huan-Hsien Kuo, Chi-Hung Lin, Yen-Ying Chen, Bei-Chia Yang, Yuan-Yuan Cheng, Alice L Yu, Kay-Hooi Khoo, John Yu*. Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation. Proc Natl Acad Sci U S A. 2010;107(52):22564-9.

13. Chang, H.S., Lin, C.H., Yang, C.H., Liang, Y.J., Yu, W.C., 2010. The human papillomavirus-16 (HPV-16) oncoprotein E7 conjugates with and mediates the role of the transforming growth factor-beta inducible early gene 1 (TIEG1) in apoptosis. The international journal of biochemistry & cell biology 42, 1831-1839. 12 citations.

14. Liang, Y.J., Chang, H.S., Wang, C.Y., Yu, W.C., 2008. DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues. The international journal of biochemistry & cell biology 40 (11), 2431-2441.