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蔡美娟

蔡美娟
神經修復研究人員
蔡美娟 May-Jywan Tsai
主要學歷:美國 馬里蘭大學 生物化學博士
◎ 現職:
  • 2001-訖今 台北榮民總醫院 副技師
◎ 經歷:
  • 1984-1987 中央研究院 生物醫學研究所 碩士助理研究員
  • 1993-2000 中央研究院 生物醫學研究所 博士後助理研究員
◎ 研究概況:
  • 神經髓鞘細胞及嗅球包被細胞之功能與分子組成研究
  • 使用骨髓幹細胞、神經幹細胞、嗅球包被細胞、神經髓鞘細胞、微小細胞等細胞移植於中樞神經系統損傷修復之研究
  • 腺病毒轉殖神經保護基因應用於中樞神經系統及周邊神經系統之研究
  • 神經膠質細胞於正常及損傷後的中樞神經系統的功能
  • 神經退化性疾病的新療法探討-發炎反應、活化的神經膠細胞及微小細胞和細胞外毒素及自由基之運用
◎ 發表論文:
  1. Shyue, S.K., M.J. Tsai, J.Y. Liou, J.T. Willerson and K.K. Wu (2001) Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer. Circulation, 103:2090-2095 (The first and 2nd authors contribute equally).

  2. Hung, SC, H. Cheng, CY Pan, M.J.Tsai, LS Kao and HL Ma (2002) In vitro differentiation of size-sieved stem cells into electrically active neural cells. Stem Cells 20:522-529.

  3. Tzeng, S.F., M.J. Tsai , S.C. Hung., H. Cheng (2004) Neuronal morphological change of size-sieved stem cells induced by neurotrophic stimuli, Neurosci Lett, 367:23-28.

  4. Tsai, M.J, S.K.Shyue, C.F. Weng, Y. Chung, D.Y. Liou, et al (2005) Selective augmentation of prostacyclin synthesis effectively reduces lipopolysaccharide- induced microglial activation. Ann. N.Y. Acad. Sci. 1042:338-348.

  5. Kuo, H.S., M.J. Tsai, M.C. Huang, W.C. Huang, M.J. Lee, W.C. Kuo, L.H. You, K.C. Szeto, I.L. Tsai, W.C. Chang, C.W. Chiu, H. Ma, K.F. Chak, H. Cheng (2007) The combination of peripheral nerve grafts and acidic fibroblast growth factor enhances arginase I and polyamine spermine expression in transected rat spinal cords. Biochem. Biophys. Res. Commun. 357(1):1-7.

  6. Tsai, M.J., C.F. Weng, S.K. Shyue, D.Y. Liou, C.H. Chen, C.W. Chiou, Barry J. Hoeffer, H.S. Kuo, M.C. Huang, W.C. Huang and Henrich Cheng (2007) Dual effect of adenovirus-mediated transfer of BMP7 in mixed neuron-glial cultures: neuro-? protection and cellular differentiation. J. Neurosci. Res .Oct;85(13):2950-9.

  7. Chou Y.H., P.L Chao, M.J. Tsai, K.B. Chen, D.M. Yang, Henrich Cheng, Anya M.-Y.Lin (2007)Arsenite induces neurotoxicity in DRG explants. Free Radic. Biol. Med. In press.

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