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張豫立 (Yuh-Lih Chang) 

2008-2009  訪問學者,美國西雅圖華盛頓大學 (University of Washington) 藥學院進修
1998-2001  國立陽明大學 藥理學 博士
1987-1991  國防醫學院 藥學系 學士

亞洲藥學會候任會長 (President elect)
中華民國藥師公會全國聯合會 醫院藥師委員會 副主委
醫策會教學醫院評鑑 儲備委員
醫策會精神醫院教學評鑑 儲備委員
陽明大學藥物科學院藥學系 兼任副教授

1. 臨床 & 藥事行政

2018-2023  臺北榮民總醫院藥學部主任
2009-2018  臺北榮總藥學部臨床藥學科 科主任
2013-2016  中華民國藥師公會全國聯合會 常務監事
2004-2009  臺北榮總藥學部臨床藥學科 總藥師
2008-2009  美國西雅圖華盛頓大學藥學院進修
2015-2018  臺北榮總人體試驗委員會 委員
1994-2002  臺北榮總臨床藥師
1993-1994  臺北榮總藥物血中濃度監測專責藥師
1992-1993  臺北榮總一般病房臨床藥師

2. 教學

2022-迄今  陽明交通大學藥學院藥學系 兼任副教授
2019-迄今  國防醫學院 臨床兼任教授

3. 專業社群


The Ishidate Award for Hospital Pharmacy, the Federation of Asian Pharmaceutical Associations (FAPA) 2018

藥品庫存管理系統 (新型M635396號 中華民國專利)
藥品傳遞智慧管理裝置 (新型M634276號 中華民國專利)
一種用於協助決定華法林藥事服務策略的系統 (新型M574731號 中華民國專利)
藥物篩選裝置 (新型第M 308081號  中華民國專利)

  1. Yu HT, Chen KH, Lin CJ, Hsu CC, Chang YL. Evaluation of the timing of using direct oral anticoagulants after ischemic stroke for patients with atrial fibrillation. Heliyon. 2023 Mar 11;9(3):e14456.
  2. Li YJ, Chang YL, Chou YC, Hsu CC. Hypoglycemia risk with inappropriate dosing of glucose-lowering drugs in patients with chronic kidney disease: a retrospective cohort study. Sci Rep. 2023 Apr 19;13(1):6373. 
  3. Ho CC, Wu SL, Tsai HY, Hu YW, Chang YL. A retrospective cohort study on the cardiotoxicity incidence rates of immune checkpoint inhibitors for oncology patients. J Chin Med Assoc. 2023 May 1;86(5):499-505. 
  4. Lee KH, Chen YF, Yeh WY, Yeh JT, Yang TH, Chou CY, Chang YL, Wang WT, Chiang CE, Chen CH, Cheng HM. Optimal stroke preventive strategy for patients aged 80 years or older with atrial fibrillation: a systematic review with traditional and network meta-analysis. Age Ageing. 2022;51(12):afac292.
  5. Li YJ, Lee WS, Chang YL, Chou YC, Chiu YC, Hsu CC. Impact of a Clinical Decision Support System on Inappropriate Prescription of Glucose-lowering Agents for Patients With Renal Insufficiency in an Ambulatory Care Setting. Clin Ther. 2022;44:710-722.
  6. Su VY, Ko SW, Chang YL, Chou YC, Lee HC, Yang KY, Chou KT, Hsu CC. Cardiovascular Medication Use and Risk of Acute Exacerbation in Patients With Asthma-COPD Overlap (CVACO Study). Allergy Asthma Immunol Res. 2022;14:314-327. 
  7. Yang YP, Chang YL, Lai YH, Tsai PH, Hsiao YJ, Nguyen LH, Lim XZ, Weng CC, Ko YL, Yang CH, Hwang DK, Chen SJ, Chiou SH, Chiou GY, Wang AG, Chien Y. Retinal Circular RNA hsa_circ_0087207 Expression Promotes Apoptotic Cell Death in Induced Pluripotent Stem Cell-Derived Leber's Hereditary Optic Neuropathy-like Models. Biomedicines. 2022 28;10:788.
  8. Huang YY, Huang YH, Wu TH, Loong CC, Hsu CC, Chou YC, Chang YL. Drug-Drug Interactions With Cyclosporine in the Anti-Hepatitis C Viral PrOD Combination Regimen of Paritaprevir/Ritonavir-Ombitasvir and Dasabuvir in Organ Transplant Recipients With Severe Hepatic Fibrosis or Cirrhosis. Ther Drug Monit. 2022;44:377-383.
  9. Wung JC, Lin HC, Hsu CC, Lin CC, Wang SY, Chang SL, Chang YL. Drug-related problem characterization and the solved status associated factor analysis in a pharmacist-managed anticoagulation clinic. PLoS One. 2022;17:e0270263.
  10. Wang YK, Wang YW, Lu CL, Huang YH, Hou MC, Chang YL, Lee WP, Lan KH. Sofosbuvir-based direct-acting antivirals and changes in cholesterol and low density lipoprotein-cholesterol. Sci Rep. 2022;12:9942.
  11. Chen WH, Lee PC, Chiang SC, Chang YL, Chen TJ, Chou LF, Hwang SJ. Pharmacist Workforce at Primary Care Clinics: A Nationwide Survey in Taiwan. Healthcare (Basel). 2021;9(7):863.
  12. Wang SF, Chang YL, Tzeng YD, Wu CL, Wang YZ, Tseng LM, Chen S, Lee HC. Mitochondrial stress adaptation promotes resistance to aromatase inhibitor in human breast cancer cells via ROS/calcium up-regulated amphiregulin-estrogen receptor loop signaling. Cancer Lett. 2021;523:82-99.
  13. Yang TH, Chou CY, Yang YF, Chien CS, Yarmishyn AA, Yang TY, Liu CH, Chang KJ, Yang YP, Chang YL. Systematic Review and Meta-analysis of the Effectiveness and Safety of Hydroxychloroquine in COVID-19. J Chin Med Assoc. 2021;84(2):233-241
  14. Lu CC, Chen MY, Lee WS, Chang YL. Potential therapeutic agents against COVID-19: What we know so far. J Chin Med Assoc. 2020;83(6):534-536
  15. Independent risk factors for death in patients admitted for asthma exacerbation in Taiwan. Chang YL, Ko HK, Lu MS, Chou CL, Su KC, Hsu CC, Chou KT, Chen TJ, Perng DW, Chou YC. NPJ Prim Care Respir Med. 2020, 19;30(1):7
  16. Hsu CC, Chien KH, Yarmishyn AA, Buddhakosai W, Wu WJ, Lin TC, Chiou SH, Chen JT, Peng CH, Hwang DK, Chen SJ, Chang YL.Modulation of osmotic stress-induced TRPV1 expression rescues human iPSC-derived retinal ganglion cells through PKA. Stem Cell Res Ther. 2019, 23;10(1):284
  17. Lin TC, Lin YY, Hsu CC, Yang YP, Yang CH, Hwang DK, Wang CY, Liu YY, Lo WL, Chiou SH, Peng CH, Chen SJ, Chang YL. Nanomedicine-based Curcumin Approach Improved ROS Damage in Best Dystrophy-specific Induced Pluripotent Stem Cells. Cell Transplant. 2019;28(11):1345-1357.
  18. Yang SN, Ko HK, Hsiao YH, Su KC, Chang YL, Huang HY, Perng DW, Chung MI. Long-acting muscarinic antagonist versus long-acting β2 agonist/corticosteroid for moderate to severe chronic obstructive pulmonary disease patients: Exacerbation risk assessment. J Chin Med Assoc. 2019;82(6):488-494.
  19. Hsu CC, Lin YY, Yang TC, Yarmishyn AA, Lin TW, Chang YL, Hwang DK, Wang CY, Liu YY, Lo WL, Peng CH, Chen SJ, Yang YP. P3HT:Bebq2-Based Photovoltaic Device Enhances Differentiation of hiPSC-Derived Retinal Ganglion Cells. Int J Mol Sci. 2019, 30;20(11).
  20. Wang CY, Yang YP, Liu CY, Lu KH, Liu YY, Wu WW, Chen KH, Chang YL, Lee SD, Lin HC. Nanoparticle-delivery system enhanced the improvement and recovery in toxicity-induced acute hepatic failure. J Chin Med Assoc. 2019;82(5):363-367.
  21. Song HY, Chien CS, Yarmishyn AA, Chou SJ, Yang YP, Wang ML, Wang CY, Leu HB, Yu WC, Chang YL, Chiou SH. Generation of GLA-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy. Cells. 2019, 8;8(4).
  22. Wang CY, Huang CS, Yang YP, Liu CY, Liu YY, Wu WW, Lu KH, Chen KH, Chang YL, Lee SD, Lin HC. The subpopulation of CD44-positive cells promoted tumorigenicity and metastatic ability in lung adenocarcinoma. J Chin Med Assoc. 2019;82(3):196-201. 
  23. Su VY, Perng DW, Chou TC, Chou YC, Chang YL*, Hsu CC, Chou CL, Lee HC, Chen TJ, Hu PW. Mucolytic Agents and Statins Use is Associated with a Lower Risk of Acute Exacerbations in Patients with Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap. J Clin Med. 2018 Dec 4;7(12). pii: E517. (*Corresponding author)
  24. Yang TH, Wu TH, Chang YL, Liao HT, Hsu CC, Tsai CY, Chou YC. Cyclosporine for the treatment of lupus nephritis inpatients with systemic lupus erythematosus. Clinical Nephrology 2018;89:277-285.
  25. Chien Y, Chou SJ, Chang YL, Leu HB, Yang YP, Tsai PH, Lai YH, Chen KH, Chang WC, Sung SH, Yu WC. Inhibition of Arachidonate 12/15-Lipoxygenase Improves α-Galactosidase Efficacy in iPSC-Derived Cardiomyocytes from Fabry Patients. International Journal of Molecular Sciences. 2018;19.
  26. Su VYF, Liao HF, Perng DW, Chou YC, Hsu CC, Chou CL, Chang YL, Yen JC, Chen TJ, Chou TC. Proton pump inhibitors use is associated with a lower risk of acute exacerbation and mortality in patients with coexistent COPD and GERD. International Journal of Chronic Obstructive Pulmonary Disease 2018;13:2907-15.
  27. Chien KH, Chang YL, Wang ML, Chuang JH, Yang YC, Tai MC, Wang CY, Liu YY, Li HY, Chen JT, Kao SY, Chen HL, Lo WL. Promoting Induced Pluripotent Stem Cell-driven Biomineralization and Periodontal Regeneration in Rats with Maxillary-Molar Defects using Injectable BMP-6 Hydrogel. Sci Rep. 2018;8(1):114.
  28. Chou SJ, Yu WC, Chang YL, Chen WY, Chang WC, Chien Y, Yen JC, Liu YY, Chen SJ, Wang CY, Chen YH, Niu DM, Lin SJ, Chen JW, Chiou SH, Leu HB. Energy utilization of induced pluripotent stem cell-derived cardiomyocyte in Fabry disease. Int J Cardiol. 2017;232:255-263.
  29. Chen KH, Chou YC, Hsiao CY, Chien Y, Wang KL, Lai YH, Chang YL, Niu DM, Yu WC. Amelioration of serum 8-OHdG level by enzyme replacement therapy in patients with Fabry cardiomyopathy. Biochem Biophys Res Commun. 2017;486(2):293-299.
  30. Tseng WL, Chou SJ, Chiang HC, Wang ML, Chien CS, Chen KH, Leu HB, Wang CY, Chang YL, Liu YY, Jong YJ, Lin SZ, Chiou SH, Lin SJ, Yu WC. Imbalanced Production of Reactive Oxygen Species and Mitochondrial Antioxidant SOD2 in Fabry Disease-Specific Human Induced Pluripotent Stem Cell-Differentiated Vascular Endothelial Cells. Cell Transplant. 2017;26(3):513-527.
  31. Chien Y, Chien CS, Chiang HC, Huang WL, Chou SJ, Chang WC, Chang YL, Leu HB, Chen KH, Wang KL, Lai YH, Liu YY, Lu KH, Li HY, Sung YJ, Jong YJ, Chen YJ, Chen CH, Yu WC. Interleukin-18 deteriorates Fabry cardiomyopathy and contributes to the development of left ventricular hypertrophy in Fabry patients with GLA IVS4+919 G>A mutation. Oncotarget. 2016;7(52):87161-87179.
  32. Li LF, Chang YL, Chen NH, Wang CY, Chang GJ, Lin MC, Chang CH, Huang CC, Chuang JH, Yang YP, Chiou SH, Liu YY. Inhibition of Src and forkhead box O1 signaling by induced pluripotent stem-cell therapy attenuates hyperoxia-augmented ventilator-induced diaphragm dysfunction. Transl Res. 2016;173:131-147.e1
  33. Tsai KL, Chang YL, Huang PH, Cheng YH, Liu DH, Chen HY, Kao CL. Ginkgo biloba extract inhibits oxidized low-density lipoprotein (oxLDL)-induced matrix metalloproteinase activation by the modulation of the lectin-like oxLDL receptor 1-regulated signaling pathway in human umbilical vein endothelial cells. J Vasc Surg. 2016;63(1):204-15.e1
  34. Jiang BH, Tseng WL, Li HY, Wang ML, Chang YL, Sung YJ, Chiou SH. Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis. Int J Mol Sci. 2015;16(7):15531-45.

2023 年 5 月
The Roles of Hospital Pharmacists during the COVID-19 Pandemic and Drug Shortage Management
臺灣藥學會與世界藥學會 (PST-FIP) 聯合研討會,瑞士日內瓦。

2023 年 3 月
The Paradigm of Future Pharmaceutical Innovation-Building Better Health System with Technology

2023 年 3 月
Global Overview of Pharmacy Practice in Health-System-Updates, Trends and Future State

2023 年 3 月

2022 年 11 月
The Roles of Hospital Pharmacist in Building up the Health System Resilience through the COVID-19 pandemic
亞洲藥學會(FAPA) 2022年會,吉隆坡馬來西亞。

2022 年 11 月
How to Mitigate Drug Shortages and Building up the Supply Chain Resilience during the COVID-19 Pandemic
亞洲藥學會(FAPA) 2022 precongress高階論壇,吉隆坡馬來西亞。

2021 年 10 月
Performance Evaluation of Clinical Pharmacists Experience from VGHTPE

2020 年 9 月
Drug Supply and Shortage Management amid COVID-19
International Good Pharmacy Practice Training Program,Webinar。

2020 年 8 月
Hospital Leadership Forum Series: Building Supply Chain Resilience and Procurement Strategies Beyond Covid-19
Johnson-Johnson-A best practice exchange by supply chain and procurement leaders,Webinar。

2020 年 7 月

2020 年 4 月
COVID-19 Infection Control and Prevention Strategies for Health-System Pharmacists and Pharmacy Departments
International Good Pharmacy Practice Training Program-Webinar

2019 年 11 月

2019 年 10 月
Engage Pharmacists in Spontaneous Reporting of Adverse Effects Following Immunization (AEFI)

2019 年 6 月

2019 年 3 月
Advance Pharmacy Practice and International collaboration of Pharmacy Alliance in Asia

2018 年 12 月
The Implementation and Development of Good Pharmacy Practice (GPP) in Asian Countries

2018 年 11 月

2018 年 10 月
Advancing Hospital Pharmacy Practice through Collaboration in Asian Countries

2018 年 7 月
Medication Management, Procurement & Inventory Control.

2018 年 7 月
Pharmacist Role in Universal Health Coverage in Taiwan

2018 年 5 月

2017 年 9 月
Pharmacotherapy Related Collaboration between Pharmacists and Physicians in A Tertiary Care Hospital
世界藥學會 (FIP) ,韓國首爾。

2016 年 11 月
Pharmacist’s Roles in A Successful Antibiotic Stewardship Program – Experiences from Taiwan

2016 年 11 月
Good Pharmacy Practice in Asia- Experiences from International Training Center & Its Prospects

2016 年 9 月
Good Procurement Practice

2016 年 9 月
Good Dispensing and Administration Practice

2015 年 8 月
Assessment of Diagnostic Replacement or Alternative treatment for Drug Shortages

2014 年 10 月
Good Pharmacy Practice in Asia- Institutional Perspectives & Experience from the International Training Center