Chen-Jee Hong (洪成志), M.D

Chief, Psychosomatic Medicine Division, Department of Psychiatry, Taipei Veterans General Hospital

    cjhong@vghtpe.gov.tw；cjhong007@gmail.com

    http://psylab.idv.tw/personnel/cjhong/cv-cjhong.asp

Professional summary:

Dr. Hong specializes in psychosomatic medicine and adult psychiatry. He teaches residents and interns how to interview psychiatric patients in clinical setting and supervises experimental researches of postgraduate students in Behavior and Gene Laboratory. In addition, he opens annual English courses for postgraduates of NYMU on the topics of psychiatric case discussion and the introduction to the treatment. He is interested in molecular pathophysiology of psychiatric disorders, including (1) finding pathogenic mutations  and providing genetic counseling for patients with early onset dementia. (2) using ENU-mutagenized mice to search genes relating to neuropsychiatric disorders. (3) using CRISPR technology and knockout mice to study the functions of genes relating neural degeneration and development. 

Current position:

Chief psychiatrist (1994~now), Division of Psychosomatic Medicine, Department of Psychiatry, Taipei Veterans General Hospital (2017~now)

Associate professor, Institute of Brain Science, National Yang-Ming University (2007~ now)

Principal investigator, Behavior and Gene Laboratory, Department of Psychiatry, Taipei Veterans General Hospital (1994~now)

Associate professor, School of Medicine, National Yang-Ming University (2005~ now)

Education：

MD, School of Medicine, National Yang-Ming University (1979-1986)

Experience：

Resident, Chief resident, Research fellow, Department of Psychiatry, Taipei Veterans General Hospital (1988~1994)

Fellow, Laboratory of Clinical Biochemistry, Department of medical research, Taipei Veterans General Hospital (1990~1992)

Fellow, Institute of Genetics, National Yang-Ming University (1992~1994)

Certification：

Certified by Taiwanese Society of Psychiatry

Expertise：

 1. Depressive disorders, anxiety disorders, sleep disorders, bipolar disorders, schizophrenia

 2. Genetic testing and consulting in dementia and intellectual disability

 3. Molecular mechanisms of neurodegenerative and neurodevelopmental diseases

 4. Animal models of psychiatric disorders

Patent(智慧財產局專利公報檢索)(USA Patent Search):

1. Amplification of Gene Fragment from Dry Blood Spots (Taiwan Invention No.152941)
2. Method and System for Measuring Motility of a Tested Animal. USA Invention No.: US 6,799,535(2004/10/05-2023/10/04); Taiwan Invention No.176000.
3. Tail suspension test apparatus.  USA Invention No.: US 6,955,139 (2005/10/18-2024/10/17). Taiwan Invention No. 200967.
4. Apparatus and Method to Evaluate the Interest of an Animal. (Taiwan Invention No. 205925. USA Invention Patent No.: US 7,121,229; Date of Patent: Oct. 17, 2006)
5. Hong CJ: Method and System for Measuring Motility of a Tested Animal. USA Invention Patent No.: US 6,799,535; Date of Patent: Oct. 5, 2004.
6. Hong CJ: Tail suspension test apparatus. USA Invention Patent No.: US 6,955,139; Date of Patent: Oct. 18, 2005.
7. Hong CJ: Method and system for evaluating interest of a tested animal. USA Invention Patent No.: US 7,121,229; Date of Patent: Oct. 17, 2006.

Awards:

1. The first prize of the Medical Technology Innovation of Taipei Veterans General Hospital, 1999
2. The 3rd prize of the Medical Technology Innovation of Taipei Veterans General Hospital, 2004
3. Excellent Teaching award of Taipei Veterans General Hospital, 2014
4. Excellent Teaching award of Taipei Veterans General Hospital, 2019

Selected Publications:

*Corresponding author  #Co-first author     

1. Hong CJ*, Hsiao KJ, Chen CH, Tsai SR, Sim CB: Urinary neopterin and biopterin levels in patients with depression. Chinese Psychiatry 1991;5:20-7.
2. CJ Hong, TY Liu, HC Liu*, SJ Wang, JL Fuh, CW Chi, KY Lee, CB Sim.  Allele of Apolipoprotein E Increases Risk of Alzheimer's Disease in a Chinese Population. Neurology 1996;46:1749-1751.
3. Chen-Jee Hong*, Hsien-Jane Chiu, Yea-Shin Chang, Cho-Boon Sim: Twelve nucleotide repeat polymorphism of DRD4 in Chinese familial schizophrenic patients. Biological Psychiatry 1998;43:432-435.
4. CJ Hong*, HL Song, HC Lai, SJ Tsai, KJ Hsiao. Methanol/Acetone treatment helps the amplification of FMR1 CGG repeat fragment in dried blood spots from Guthrie cards. Lancet 1999; 353(9159):1153-1154.
5. Liu HC*, Hong CJ, Wang SJ, Fuh JL, Wang PN, Shyu HY, Teng EL. ApoE genotype in relation to AD and cholesterol- a study of 2,326 Chinese adults. Neurology 1999;53:962-966.
6. Chen-Jee Hong, Joseph J Cheng,Tzung-Jeng Hwang, Ying-Sheue Chen, Shi-Chin Guo, Hsien-Yuan Lane, Ying-Chiao Lee, Fan Zhang, Wen-Ho Chang, Pierre Tran, Hai-Gwo Hwu*. A Double-Blind Study on the Efficacy and Safety of Olanzapine versus Haloperidol in the Treatment of Schizophrenic Patients. Taiwanese J Psychiatry 2001;15(3):184-192.
7. Yu YWY, Tsai SJ, Chen TJ, Lin CH, Hong CJ*. Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Molecular Psychiatry 2002;7:1115-1119 
8. Hong CJ, Hu WH, Chen CC, Hsiao CC, Tsai SJ*, Ruwe FJL. A double-blind, randomized, group-comparative study of the tolerability and efficacy of 6 weeks’ treatment with mirtazapine or fluoxetine in depressed Chinese patients. Journal of Clinical Psychiatry 2003;68(8):921-926. 
9. Hong CJ, Tsai PJ, Cheng CY, Chou CK, Jheng HF, Chuang YC, Yang CN, Lin YT, Hsu CW, Cheng IH, Chen SY, Tsai SJ, Liou YJ, Tsai YS*. ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. PLoS One. 2010;5(12):e15333.
10. 洪成志、廖敏華、王正如、鄭之雅：遺傳性失智症的基因檢測與諮詢。台灣醫界 2011;54(9):10-18.
11. Wang PN, Hong CJ, Lin KN, Liu HC, Chen WT. APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan. J Neurol Neurosurg Psychiatry. 2011;82(2):165-9.
12. Yang AC*, Tsai SJ, Yang CH, Kuo CH, Chen TJ, Hong CJ*. Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia. J Affect Disord. 2011;131(1-3):179-85.
13. Chen WT, Hong CJ, Lin YT, Chang WH, Huang HT, Liao JY, Chang YJ, Hsieh YF, Cheng CY, Liu HC, Chen YR, Cheng IH.Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies. PLoS One. 2012;7(4):e35807.
14. Liou YJ, Wang HH, Lee MT, Wang SC, Chiang HL, Chen CC, Lin CH, Chung MS, Kuo CC, Liao DL, Wu CK, Liu CM, Liu YL, Hwu HG, Lai IC, Tsai SJ, Chen CH, Liu HF, Chou YC, Chen CH, Chen YT, Hong CJ*, Wu JY*. Genome-wide association study of treatment refractory schizophrenia in Han Chinese. PLoS One. 2012;7(3):e33598.(pdf)
15. Liou YJ, Chen CH, Cheng CY, Chen SY, Chen TJ, Yu YW, Nian FS, Tsai SJ, Hong CJ*. Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response. PLoS One. 2012;7(5):e32984.
16. Cheng CY, Wu JC, Tsai JW, Nian FS, Wu PC, Kao LS, Fann MJ, Tsai SJ, Liou YJ, Tai CY, Hong CJ*. ENU mutagenesis identifies mice modeling Warburg Micro syndrome with sensory axon degeneration caused by a deletion in Rab18. Experimental