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Chief

Chief

Han-Shui Hsu, MD,PhD

 

Personal Information

Position                     Professor & Chief
                                    Division of Thoracic Surgery, Department of Surgery, 
                                    Taipei Veterans General Hospital

                                     Director,
                                     Institute of Emergency and Critical Care Medicine
                                     National Yang-Ming University School of Medicine

Address                      No 201, Section 2, Shih-Pai Road, Taipei, Taiwan

TEL:                               886-2-28757546

e-mail address:            hsuhs@vghtpe.gov.tw

 

Education and Residency

Education:                        Ph.D. Institute of Clinical Medicine, National Yang-Ming University School of Medicine (2005-2007)

                                          M.D. National Yang-Ming University School of Medicine

Army:                                Airforce (1990-1992)

       

Residency:                       Division of Thoracic Surgery
                                         Department of Surgery, Taipei Veterans General Hospital (1992-1997)

                                      

Expertise

Lung Transplantation, Lung Cancer Surgery, Esophageal Cancer, Mediastinal Tumor, Myasthenia Gravis, VATS

 

Experience

Attending Surgeon, Taoyuan Veterans Hospital (1997-1999)

Attending Surgeon, Taipei Veterans General Hospital (19990presnet)

Assistant Professor, Department of Surgery, National Yang-Ming University (2005-8)

Assistant Professor, Institute of Emergency and Critical Care Medicine, National Yang-Ming University (2008-9)

Associate Professor, Institute of Emergency and Critical Care Medicine, National Yang-Ming University (2009~2012)

Professor, Institute of Emergency and Critical Care Medicine, National Yang-Ming University (2012~)

Clinical Observer, Thoracic Surgery, Washington University in St Louis Medical Center (August 2000- May-2001)

Clinical Observer, Department of Surgery, University of Southern California in LA (June 2001- July 2001)

Clinical Observer, Berlin Heart Center (DHZB), Germany (May 2008)

Editorial Board

Global Journal of Surgery

World Journal of Respirology

Asian Journal of Surgery

 

Reviewer

1. Annals of Thoracic Surgery

2. European Journal of Thoracic and Cardiovascular Surgery

3. World Journal of Surgery

4. Journal of Medical Sciences

5. Formosan Journal of Surgery

6. Lung Cancer

7. International Journal of Cancer

8. Annals of Surgical Oncology

9. Journal of Cardiothoracic Surgery

10. Asian Journal of Surgery

11. Cancer Research

12. Experimental Cell Research

13. BMJ Open

14. PLOS ONE

 

 

Invited Lectures

1. Management of Stage I Non-small-cell Lung cancer. (2008/8/21)

2. Diagnostic, Therapeutic and Prognostic Significance of Sternal Fracture. (2008/12/13)

3. Epigenetic Alteration of hMLH1 and hMSH2 Mismatch Repair Genes and Methylation Biomarkers for Risk Assessment in Non-small-cell Lung Cancer. The 17th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery (March 5-8, 2009, Taipei)

4. Management of Stage I Non-small-cell Lung cancer. (2009/4/22)

5. Management of Stage I Non-small-cell Lung cancer. (2009/6/17)

6. Epigenetic Alterations and Potential Application of Epigenetic Biomarkers in Lung Cancer. (2009/6/18) 7. Nutritional Support and Immune Modulation in ICU. (2011/11/08)

8. Nutritional Support and Immune Modulation in ICU. (2012/1/04)

9. From Jacobaeus to the Da Vinci. Thoracoscopic Applications of the Robot. (2012/6/27)

10. From Jacobaeus to the Da Vinci. Thoracoscopic Applications of the Robot (2013/1/2)

11. How to develop the quality indicators for nutrition therapy in hospital?(2013/4/20)

12. Surgical Thoracic Diseases. (2013/7/21)

13. IL-6 Enriched Lung Cancer Stem-like Cell Population by Inhibition of Cell Cycle Regulators via DNMT1 Up-regulation. Thoracic Research Camp. 2014 Seoul National University Bundang Hospital. (2014/2/15) 103年2月15日

14. Lung Cancer Stem Cells: A biological and clinical perspective (2014/3/13) National Health Institute(Institute of Cell and Systemic Medicine)

15. Surgical Thoracic Diseases. (2014/7/27)

16. VATS Lobectomy Video Sharing. (2014/8/6) 103年3月13日 Department of Thoracic Surgical Oncology, Cancer Institute Hospital, Tokyo, Japan

17. The Effectiveness of Treatment and Nutritional Support in Patients with Postoperative Chylothorax. (2015/7/24~26) Poster presentation at 16th PENSA Congress at Nagoya, Japan

18. Nutritional Management of Patients with Esophageal Cancer (2015/10/17) 104年10月17日TSPEN Annual Meeting

18. The Interaction of Lung Cancer Stem Cells with the Tumor Microenvionment. (2015/10/31) 104年10月31日Thoracic Surgical Club

20. Perioperative Immunonutrition in Esophageal Cancer (2015/12/05)

 

 

Grants

Living-related Donor Lobectomy for Lobar Transplantation-Setup of Animal Model.

Continuous Cyclic Ventilation of Allograft in Cold Storage for Lung Preservation.

Two-layer Method (UW solution/Perfluorochemical plus O2) for Lung Preservation in Rat Lung Transplantation.

Antegrade versus Retrograde Flush for Lung Preservation in Canine Pulmonary Transplantation.(2003)

The Effect of Cyclooxygenase-2 Inhibitor, NS-398, in Rat Lung Transplantation.  Cyclooxygenase-2 Inhibitor(NS-398)(2004)

The Prognostic Significance of p53/MDM2/P14ARF Pathway in Non-small Cell Lung Cancer.(2004)

Alteration of DNA Methyltransferase Expression and Its Association with DNA Methylation of CpG Islands in Human Non-small Cell Lung Cancer. (NSC 2004)

The Significance of hMLH1 and hMSH2 Inactivation by Promoter Methylation in Female with Non-small Cell Lung Cancer. (2005)

Retrograde Flush in Canine Lung Transplantation with Non-heart-beating Donors.(2005)

The Prognostic Significance of Preoperative CEA Serum Level in Female with Non-small Cell Lung Cancer. (2005)

Molecular Evaluation of Inhibitors of Protein Kinase B/AKT on Therapeutic Treatment of Lung Cancer. (2006)

Lung Retrieval from Non-heart-beating Donors in Rat Lung Transplantation Model.(2006)

Relapse of Symptom After Transsternal Thymectomy for Myasthenia Gravis.(2006)

Polymorphic Analysis of Mismatch Repair Genes hMLH1 and hMSH2 with Lung Cancer Susceptibility and Prognosis in Taiwan.(NSC 2006)

The Significance of Cell Cycle Regulators CDKN2A(p16INK4a and p14ARF)and p53 genes in Squamous Cell Carcinoma of the Esophagus.(2007)

En Bloc Resection for Lung Cancer with Chest Wall Invasion.(2007)

MDM2 Regulation by eIF4E and Their Implication in Squamous cell Carcinoma of the Esophagus.(2007)

Epigenetic Biomarkers in Plasma Samples for Early Detection of Lung Cancer. (2008)

The Treatment Effect of Norcantharidin Derivatives on Lung Cancer Stem Cell. (2008)

The Significance of β-Catenin and P53 Protein Expression in Squamous Cell Carcinoma of the Esopahgus. (2008)

 Role of hRAB37 Gene and Its Effect on Cell Migration and Metastasis in Lung Cancer. (NSC 2008~2010)

The Significance of HOXA9 and eIF4E Protein Coexpression in Squamous Cell Carcinoma of the Esophagus. (2009)

 Investigation of Role of NCTD and HDAC Inhibitors in Lung Cancer Stem Cells. (2009)

The Significance of Axin Protein Expression in Squamous Cell Carcinoma of the Esopahgus.(2009)

Investigation of role of NCTD and CAPE in anti-cancer effect in lung cancer stem cells. (2010) 

The Clinical Implication of MDM2 and NBS1/Mre11/Rad50 complex in Esophageal Cancer. (2010)

The Role of CBL, c-Met及EGFR Genes in Lung Cancer.(NSC 2010~2012)

Role of HSP27 Activation in Chemo-resistance of Lung Cancer Stem Cells.(2011)

The Role of Mesenchymal Stem Cells in Lung Cancer Initiation. (2011)

Study of miR-145 in Regulating Cancer Stem-like and Metastatic Property and Developing as a Therapeutic Target for Lung Cancer. (NRPB 2011~2014)

The Clinical Significance of 4E-BP1 and Its Influence to eIF4E and MDM2 Expression in Squamous Cell Carcinoma of the Esophagus.(2012)

Mesenchymal Stem Cells in Lung Cancer Initiation: The Role of IL6 and DNA methyltransferase.(2012)

The Role of 4E-BP1/eIF4E Ratio in the Response after Rapamycin Treatment in Esophageal Cancer Cells. (2013)

The Role of Cell Cycle Regulators in IL6-Stimulated Lung Cancer Stem-like Cells.(2013)

The Surgical Results of Nonmyasthenic Patients with Early Thymomas.(2013)

The Role of Basal Cells and β-catenin in Repairing of Naphthalene-induced Acute Tracheal Injury.(2014)

The Role of Egr-1 and 4E-BP1 in Esophageal Cancer Stemlike Cells.(2014)

The Role of Collagen XVII/laminin 5 Signal Pathway and Epithelial-to-Mesenchymal Transition in Lung Cancer Stem-like Cells.(NSC 2014~2016)

 

Board

Member of Taiwan Surgical Society

Member of Association of Taiwan Thoracic and Cardiovascular Surgery

Member of Association of Taiwan Pulmonary and Critical Care Medicine

Member of Taiwan Trauma Association

Member of Association of Taiwan Endoscopic Surgery

Member of American Society of Thoracic Surgeon

Member of International Society of Surgery

 

Publications（2017-2021）

  1. Tu CC, Hsu PK, Chien LI, Liu WC, Huang CS, Hsieh CC, Hsu HS, Wu YC. Prognostic histological factors in patients with esophageal squamous cell carcinoma after preoperative chemoradiation followed by surgery. BMC Cancer. 2017 Jan 19;17(1):62.
  2. Hsu PK, Chen HS, Huang CS, Liu CC, Hsieh CC, Hsu HS, Wu YC, Wu SC. Patterns of recurrence after oesophagectomy and postoperative chemoradiotherapy versus surgery alone for oesophageal squamous cell carcinoma. Br J Surg. 2017 Jan;104(1):90-97.
  3. Guo JY, Hsu HS, Tyan SW, Li FY, Shew JY, Lee WH, Chen JY. Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner. Oncogene. 2017 Apr 27;36(17):2457-2471.
  4. Tsung YC, Chung CY, Wan HC, Chang YY, Shih PC, Hsu HS, Kao MC, Huang CJ.Dimethyl Sulfoxide Attenuates Acute Lung Injury Induced by Hemorrhagic Shock/Resuscitation in Rats. Inflammation. 2017 Apr;40(2):555-565.
  5. Yen-Chiang Tseng, Yen-Han Tseng, Hua-Lin Kao, Chih-Cheng Hsieh, The-Ying Chou, Yih-Gang Goan, Wen-Hu Hsu, Han-Shui Hsu*. Long term oncological outcome of thymoma and thymic carcinoma- an analysis of 235 cases from a single institution. Plos one, 2017 Jun 20;12(6):e0179527. doi: 10.1371/journal.pone.0179527. eCollection 2017.
  6. Hsu PK, Chen HS, Liu CC, Huang CS, Hsieh CC, Hsu HS, Wu SC. Pre- versus postoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg. 2017 Aug;154(2):732-740.
  7. Hsu HS*, Liu CC, Lin JH, Hsu TW, Hsu JW, Su K, Hung SC. Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis. Sci Rep. 2017 Oct 27;7(1):14272. doi: 10.1038/s41598-017-14612-5.
  8. Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Jer-Wei Chang, Kelly Su, Han-Shui Hsu*, Shih-Chieh Hung. Collagen XVII/Laminin-5 Activates Epithelial-to-Mesenchymal Transition and Is Associated with Poor Prognosis in Lung Cancer. Oncotarget 2018 Jan 5;9(2):1656-1672(Correspondence Author).
  9. Chiu YJ, Yang JS, Hsu HS, Tsai CH, Ma H. Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma. Oncol Rep. 2018 Feb;39(2):651-658.                      
  10. Chih-Cheng Hsieh, Han-Shui Hsu, Anna Fen-Yau Li, Yann-Jang Chen.Clinical relevance of PD-L1 and PD-L2 overexpression in patients with esophageal squamous cell carcinoma. J Thorac Dis. 2018 Jul;10(7):4433-4444.
  11. Po-Kuei Hsu, Ling-I Chien, Chih-Hung Lin, Yi-Chen Yeh, Cheng-Yen Chuang, Han-Shui Hsu, Yu-Chung Wu, Chung-Ping Hsu. Impact of perineural invasion as a histopathological prognostic factor in ypStage II/III oesophageal squamous cell carcinomat.Eur J Cardiothorac Surg. 2019 May 1;55(5):927-933.
  12. Chou KT, Cheng SC, Huang SF, Perng DW, Chang SC, Chen YM, Hsu HS, Hung SC. Impact of Intermittent Hypoxia on Sepsis Outcomes in a Murine Model. Sci Rep. 2019 Sep 9;9(1):12900. doi: 10.1038/s41598-019-49381-w.
  13. Chen‐Chi Liu Kun‐Ta Chou   Jyuan‐Wei Hsu   Jiun‐Han Lin   Tien‐Wei Hsu David Hung‐Tsang Yen   Shih‐Chieh Hung   Han‐Shui Hsu*. High metabolicrate and stem cell characteristics of esophageal cancer stem-like cells depend on the Hsp27-AKT-HK2 pathway.Int J Cancer. 2019 Oct 15;145(8):2144-2156.
  14. Yi-Ying Lee , Po-Kuei Hsu , Chien-Sheng Huang , Yu-Chung Wu and Han-Shui Hsu.Complications after Chest Tube Removal and Reinterventions in Patients with Digital Drainage.Systems.J Clin Med. J Clin Med. 2019 Dec 1;8(12):2092.
  15. Cheng IY, Liu CC, Lin JH, Hsu TW, Hsu JW, Li AF, Ho WC, Hung SC, Hsu HS*. Particulate matter increases the severity of bleomycin-induced pulmonary fibrosis through KC-mediated neutrophil chemotaxis. Int J Mol Sci. 2020 Jan; 21(1): 227.
  16. Han-Shui Hsu, Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Anna Fen-Yau Li, Shih-Chieh Hung . Involvement of Collagen XVII in Pluripotency Gene Expression and Metabolic Reprogramming of Lung Cancer Stem Cells. J Biomed Sci. 2020 Jan 13;27(1):5. doi: 10.1186/s12929-019-0593-y.
  17. Hsu CP, Chuang CY, Hsu PK, Chien LI, Lin CH, Yeh YC, Hsu HS, Wu YC. Lymphovascular Invasion as the Major Prognostic Factor in Node-Negative Esophageal Cancer After Primary Esophagectomy. J Gastrointest Surg. 2020 Jul;24(7):1459-1468.
  18. Lin CM, Tu CC, Yeh YC, Hsu PK, Chien LI, Huang CS, Wu YC, Hsu HS. The Prognostic Impact of Extracapsular Lymph Node Involvement in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2020 Aug;27(8):3071-3082.
  19. Liu CY, Hsu PK, Hsu HS, Wu YC, Chuang CY, Lin CH, Hsu CP. Prognostic impact of circumferential resection margin in esophageal cancer with or without neoadjuvant chemoradiotherapy. Dis Esophagus. 2020 Sep 4;33(9):doz114.
  20. Lin YH, Chen CK, Hsieh CC, Hsu WH, Wu YC, Hung JJ, Hsu PK, Hsu HS*. Lymphadenectomy is Unnecessary for Pure Ground-Glass Opacity Pulmonary Nodules. J Clin Med. 2020 Mar 2;9(3):672.
  21. Huang CS, Hsu PK, Chen CK, Yeh YC, Hsu HS, Shih CC, Huang BS. Surgeons' preference sublobar resection for stage I NSCLC less than 3 cm. Thorac Cancer. 2020 Apr;11(4):907-917.
  22. Hung CT, Chen CK, Chang YY, Hsu PK, Hung JJ, Huang CS, Wu YC, Hsu HS. Electromagnetic navigation-guided versus computed tomography-guided percutaneous    localization     of    small    lung     nodules    before     uniportal video-assisted thoracoscopic surgery: a propensity score-matched analysis. Eur J Cardiothorac Surg. 2020 Aug 1;58(Supplement_1):i85-i91.
  23. Chang CJ, Chiang LL, Chen KY, Feng PH, Su CL, Hsu HS*. High-Flow Nasal Cannula versus Noninvasive Positive Pressure Ventilation in Patients with Heart Failure after Extubation: An Observational Cohort Study. Can Respir J. 2020 Jul 3;2020:6736475.
  24. Inciong JFB, Chaudhary A, Hsu HS, Joshi R, Seo JM, Trung LV, Ungpinitpong W, Usman N. Hospital malnutrition in northeast and southeast Asia: A systematic literature review. Clin Nutr ESPEN. 2020 Oct;39:30-45.
  25. Hung HY, Tseng YH, Chao HS, Chiu CH, Hsu WH, Hsu HS, Wu YC, Chou TY, Chen CK, Lan KL, Chen YW, Wu YH, Chen YM. Multidisciplinary team discussion results in survival benefit for patients with stage III non-small-cell lung cancer. LoS One. 2020 Oct 8;15(10):e0236503.
  26. Lin YH, Hsu HS*. Ground glass opacity on chest CT scans from screening to treatment: A literature review. J Chin Med Assoc. 2020 Oct;83(10):887-890.
  27. Hsu PK, Yeh YC, Chien LI, Huang CS, Hsu HS. Clinicopathological Significance of Pathologic Complete Lymph Node Regression After Neoadjuvant Chemoradiotherapy in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2020 Nov 20. doi: 10.1245/s10434-020-09363-z. Online ahead of print.
  28. Huang CS, Chien HC, Chen CK, Yeh YC, Hsu PK, Chen HS, Hsieh CC, Hsu HS, Huang BS, Shih CC. Significance of preoperative biopsy in radiological solid-dominant clinical stage I non-small-cell lung cancer. Interact Cardiovasc Thorac Surg. 2020 Dec 17;ivaa297. doi: 10.1093/icvts/ivaa297. Online ahead of print.
  29. Tsai PC, Hsu PK, Yeh YC, Chen CK, Chang YY, Huang CS, Hsu HS. Active surveillance or early resection for ground-glass nodules that need preoperative localization. J Surg Oncol. 2021 Jan;123(1):322-331.
  30. Yi-Chung Chen, Yi-Han Lin, Hung-Che Chien, Po-Kuei Hsu, Jung-Jyh Hung, Chien-Sheng Huang, Chih-Cheng Hsieh, Wen-Hu Hsu, Han-Shui Hsu*. Preoperative Consolidation-to-tumor ratio is effective in the prediction of lymph node metastasis in patients with pulmonary ground-glass component nodules. Thorac Cancer. 2021 Apr;12(8):1203-1209.
  31. Hsin-Hsien Li, Chen-Chi Liu, Tien-Wei Hsu, Jiun-Han Lin, Jyuan-Wei Hsu, Anna Fen-Yau Li, Yi-Chen Yeh, Shih-Chieh Hung, and Han-Shui Hsu*. Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19. Part Fibre Toxicol. 2021 Mar 11;18(1):11.
  32. Chan LY, Wang LC, Hsu HS*.Silent Angiomatoid Fibrous Histiocytoma of the Chest Wall. Ann Thorac Surg. 2021 May;111(5):e347-e348. doi: 10.1016/j.athoracsur.2020.08.063. Epub 2020 Nov 4.D: 33159863.
  33. Lin PY, Yen YT, Lam CT, Li KC, Lu MJ, Hsu HS*. Use of modified-NUTRIC score to assess nutritional risk in surgical intensive care unit.J Chin Med Assoc. 2021 Jun 8. doi: 10.1097/JCMA.0000000000000565. Online ahead of print.PMID: 34108425.
  34. Po-Kuei Hsu, Ling-I Chien, Chien-Sheng Huang, Yi-Chen Yeh, Pin-I Huang, Ming-Huang Chen, Sheng-Yu Chen, Chueh-Chuan Yen, Han-Shui Hsu. ASO Visual Abstract: Treatment Patterns and Outcomes for Patients with Esophageal Cancer-An Analysis of a Multidisciplinary Tumor Board Database. Ann Surg Oncol. 2022 Jan;29(1):572-585. doi: 10.1245/s10434-021-10568-z. Epub 2021 Aug 13.
  35. Hui-Chun Chang, Chung-Han Ho, Shu-Chen Kung, Wan-Lin Chen, Ching-Min Wang, Kuo-Chen Cheng, Wei-Lun Liu, Han-Shui Hsu. Maintenance of low driving pressure in patients with early acute respiratory distress syndrome significantly affects outcomes. Respir Res. 2021 Dec 15;22(1):313. doi: 10.1186/s12931-021-01912-8.

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