Brief CV of Professor Bing-wen Soong

Education      

National Defense Medical College, M.D. 1971~1978

National Yang-Ming University, Ph.D. 1989~1992

Professional Experience       

1. -Faculty physician and Chair, Division of Peripheral Nervous System Disorders, Neurological Institute, Taipei Veterans General Hospital, Taiwan, 2013~2018.
2. Professor and Chair, Section of Neurology, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, 2012~2018.
3. Founding President, the Society of Neurological Rare Disorders, Taiwan (SNeRD-T), 2016~2019.
4. Associate Editors of Journal of Neurogenetics、Cerebellum and Ataxias、The Cerebellum.
5. Founding Chair, Section of Neurogenetics, Taiwan Neurological Society, 2003~2005

Focus

1. Clinical and genetic research of neurodegenerative disorders, i.e. cerebellar ataxias, Huntington’s disease, CADASIL, Kennedy disease.
2. Clinical trials of therapies for neurodegenerative disorders.
3. Botulinum therapy.

Awards and Honors

1. The “Outstanding Leadership in Clinical Research by a Principal Investigator” award granted by the Association of Clinical Research Professional, 2017.
2. The SNQ (Symbol of National Quality) award (“Services and Research for Cerebellar Ataxias”), Institute for Biotechnology and Medicine Industry, Taiwan, 2016.
3. Outstanding Research Award, Ministry of Science and Technology, R.O.C., 2015
4. Medical Innovation Award (the Second Place), Taipei Veterans General Hospital, ROC, 2015.
5. Best Research Paper Award (the second place), Taipei Veterans General Hospital, ROC, 2014.
6. Best Research Paper Award (the second place), Taipei Veterans General Hospital, ROC, 2013.
7. Excellence in Research Award, National Yang-Ming University, ROC, 2011-2019.

Selected Publications

1. Soong BW, Cheng CH, Liu RS, Shan DE. Machado-Joseph disease: clinical, molecular, and metabolic characterization in Chinese kindreds. Ann Neurol 1997 April;41(4):446-52.

1. Soong BW, Lu YC, Choo KB, Lee HY. Frequency analysis of autosomal dominant cerebellar ataxias in Taiwanese patients and clinical and molecular characterization of spinocerebellar ataxia type 6. Arch Neurol 2001 Jul:58(7):1105-9.

1. Shan DE, Soong BW, Sun CM, Lee SJ, Liao KK, Liu RS. Spinocerebellar ataxia type 2 presenting as familial levodopa-responsive parkinsonism. Ann Neurol 2001 Dec;50(6):812-5.

1. Chung MY, Lu YC, Cheng NC, Soong BW. A novel autosomal dominant spinocerebellar ataxia (SCA22) linked to chromosome 1p21-q23. Brain 2003 Jun;126(6):1293-9.

1. Lin YS, Chen CM, Soong BW, Wu YR, Chen HM, Yeh WY, Wu DR, Lin YJ, Poon PWF, Wang CH, and Chern YJ. Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease. J Clin Invest 2011 Apr;121(4):1519-23.

1. Lee YC, Durr A, Majczenko K, Huang YH, Liu YC, Lien CC, Tsai PC, Ichikawa Y, Goto J, Monin ML, Li JZ, Chung MY, Mundwiller E, Shakkottai V, Liu TT, Tesson C, Lu YC, Brice A, Tsuji S, Burmeister M, Stevanin G, Soong BW. Mutations in KCND3 Cause Spinocerebellar Ataxia Type 22. Ann Neurol 2012 Dec 31;72(6):859-69. (Highlighted by Ellen Bible in Nature Reviews Neurology2012;8:472 entitled: “Mutations in KCND3 linked to SCAs”)

1. Soong BW, Huang YH, Tsai PC, Huang CC, Pan HC, Lu YC, Chien HJ, Liu TT, Chang MH, Lin KP, Tu PH, Kao LS,* Lee YC.* Exome Sequencing Identifies GNB4 Mutations as a cause of Dominant Intermediate Charcot-Marie-Tooth Disease. Am J Hum Genet 2013 Mar 7;92(3):422-30.

1. Guo YC, Lin JJ, Liao YC, Tsai PC, Lee YC, Soong BW. Spinocerebellar ataxia 35: novel mutations in TGM6 with clinical and genetic characterization. Neurology 2014 Oct 21;83(17):1554-61.

1. Lee YC, Tsai PC, Guo YC, Hsiao CT, Liu GT, Liao YC, Soong BW.* Spinocerebellar ataxia type 36 in the Han-Chinese. Neurol Genet 2016 Apr 12;2(3):e68.

1. Tsai YA, Liu RS, Lirng JF, Yang BH, Chang CH, Wang YC, Wu YS, Ho JHC, Lee KS, Soong BW.* Treatment of Spinocerebellar Ataxia with Mesenchymal Stem Cells: A Phase I/IIa Clinical Study. Cell Transplantation 2017 Mar 13;26(3):503-512.