Chih-Chien Hsu

Ophthalmology

Attending physician

Cornea

2004-2005 Internship, Taichung  Veterans General Hospital, Taichung, Taiwan
2007-2011 Residency, Ophthalmology, Taipei Veterans General Hospital, Taipei,Taiwan
2011-2012 Fellowship, Retina Service, Taipei Veterans General Hospital, Taipei,Taiwan
2011-2012 Fellowship, Cornea Service, Taipei Veterans General Hospital, Taipei,Taiwan
2012-2016  Attending Physician, Cornea Service, Taipei Veterans General Hospital, Taipei,Taiwan
2017-2018 Research Fellowship, Wilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, MD
2018-present Attending Physician, Cornea Service, Taipei Veterans General Hospital, Taipei,Taiwan

National board of Ophthalmology

Taiwan medical licensing examination

2011 – Present The Ophthalmological Society of Taiwan
2015 – Present Administrative secretary of Cataract Surgery Committee,  The Ophthalmological Society of Taiwan
2019 - Present Member of Contact Lens and Orthokeratology Group,  Refractive Correction Committee,  The Ophthalmological Society of Taiwan
2021 - Present Member of Laser Refractive Surgery Group,  Refractive Correction Committee,  The Ophthalmological Society of Taiwan
2021 - Present Deputy Secretary-general, Taiwan Medical Society for Refraction and Optometry
2021- Present Member of Young Ophthalmologist Committee, The Ophthalmological Society of Taiwan

2022- Present Director  of Intraocular Implant &Refractive Society of Taiwan

Research Areas
1. Myopia. 
2. Atificial intelligence in ophthalmology
3. Stem cells
4. Big data
5. Ocular surface diseases
6  Cataract and refractive surgey

1. Hsu CC, Chuang HK*, Hsiao YJ, Teng YC, Chiang PH, Wang YY, Lin TY, Tsai PH, Weng CC, Lin TC, Hwang DK*, Hsieh AR* Polygenic Risk Score Improves Cataract Prediction in East Asian Population. Biomedicine. 2022,10(8), 1920
2. Hsiao YJ, Chuang HK, Chi SC, Wang YY, Chiang PH, Teng PC, Kuang TM, Yarmishyn AA, Lin TC, Hwang DK, Chen SJ, Chiou SH, Chen MJ, Hsieh AR*, Hsu CC*.Genome-Wide Polygenic Risk Score for Predicting High Risk Glaucoma Individuals of Han Chinese Ancestry. J Pers Med. 2021 Nov 9;11(11):1169.
3. Chang JY, Lin PY, Hsu CC*, Liu CJ. Comparison of Clinical Outcomes of LASIK, Trans-PRK and SMILE for Correction of Myopia. J Chin Med Assoc.2022,1;85(2):145-151
4. Hsu CC, Kuo YS, Lin PY*, Chen KH. Overnight Orthokeratology-Associated Acanthamoeba Keratitis at a Tertiary Referral Hospital in Taiwan: A Retrospective Case-control Study..
5. Lin TY, Chang YC, Hsiao YJ, Chien Y, Jheng YC, Wu JR, Ching LJ, Hwang DK, Hsu CC, Lin TC, Chou YB, Huang YM, Chen SJ, Yang YP, Tsai PH. Identification of Novel Genomic-Variant Patterns of OR56A5, OR52L1, and CTSD in Retinitis Pigmentosa Patients by Whole-Exome Sequencing. Int J Mol Sci. 2021 May 25;22(11):5594.
6. Ahmad Mulyadi Lai HI, Chou SJ, Chien Y, Tsai PH, Chien CS, Hsu CC, Jheng YC, Wang ML, Chiou SH, Chou YB, Hwang DK, Lin TC, Chen SJ, Yang YP. Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids. Int J Mol Sci. 2021 Jan 28;22(3):1320.
7. Chang YA, Wu YY, Lin CT, Kawasumi M, Wu CH, Kao SY, Yang YP, Hsu CC, Hung KF, Sun YC. Animal models of dry eye: Their strengths and limitations for studying human dry eye disease. J Chin Med Assoc. 2021 May 1;84(5):459-464.
8. Chiu W, Lin TY, Chang YC, Isahwan-Ahmad Mulyadi Lai H, Lin SC, Ma C, Yarmishyn AA, Lin SC, Chang KJ, Chou YB, Hsu CC, Lin TC, Chen SJ, Chien Y, Yang YP, Hwang DK. An Update on Gene Therapy for Inherited Retinal Dystrophy: Experience in Leber Congenital Amaurosis Clinical Trials. Int J Mol Sci. 2021 Apr 26;22(9):4534.
9. Hwang DK, Chou YB, Lin TC, Yang HY, Kao ZK, Kao CL, Yang YP, Chen SJ, Hsu CC*, Jheng YC*. Optical coherence tomography-based diabetic macula edema screening with artificial intelligence. J Chin Med Assoc. 2020 Nov;83(11):1034-1038
10. Hwang DK, Yu WK, Lin TC, Chou SJ, Yarmishyn A, Kao ZK, Kao CL, Yang YP, Chen SJ, Hsu CC*, Jheng YC*. Smartphone-based diabetic macula edema screening with an offline artificial intelligence. J Chin Med Assoc. 2020 Dec;83(12):1102-1106
11. Chen MJ, Chang KJ, Hsu CC*, Lin PY, Liu CJ. Precaution and Prevention of Coronavirus Disease 2019 (COVID-19) Infection in the Eye. J Chin Med Assoc. 2020 Apr 21. doi: 10.1097/JCMA.0000000000000334. [Epub ahead of print]
12. Yang TC, Yarmishyn AA, Yang YP, Lu PC, Chou SJ, Wang ML, Lin TC, Hwang DK, Chou YB, Chen SJ, Yu WK, Wang AG, Hsu CC*, Chiou SH. Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients. Hum Mol Genet. 2020 Apr 10. pii: ddaa063. doi: 10.1093/hmg/ddaa063. [Epub ahead of print]
13. Chang YF, Ko YC, Hsu CC, Chen MJ, Liu CJ. Glaucoma assessment in high myopic eyes using optical coherence tomography with long axial length normative database. J Chin Med Assoc. 2020 Mar;83(3):313-317. doi: 10.1097/JCMA.0000000000000254.
14. Yang TC, Chang CY, Yarmishyn AA, Mao YS, Yang YP, Wang ML, Hsu CC, Yang HY, Hwang DK, Chen SJ, Tsai ML, Lai YH, Tzeng Y, Chang CC, Chiou SH. Carboxylated nanodiamond-mediated CRISPR-Cas9 delivery of human retinoschisis mutation into human iPSCs and mouse retina. Acta Biomater. 2020 Jan 1;101:484-494. doi: 10.1016/j.actbio.2019.10.037. Epub 2019 Oct 28.
15. Huang PC, Hsiao YC, Tsai CY, Tsai DC, Chen CW, Hsu CC, Huang SC, Lin MH, Liou YM. Protective behaviours of near work and time outdoors in myopia prevalence and progression in myopic children: a 2-year prospective population study. Br J Ophthalmol. 2019 Oct 15. pii: bjophthalmol-2019-314101. doi: 10.1136/bjophthalmol-2019-314101. [Epub ahead of print]
16. Hsu CC, Chien KH, Yarmishyn AA, Buddhakosai W, Wu WJ, Lin TC, Chiou SH, Chen JT, Peng CH, Hwang DK, Chen SJ, Chang YL. Modulation of osmotic stress-induced TRPV1 expression rescues human iPSC-derived retinal ganglion cells through PKA. Stem Cell Res Ther. 2019 Sep 23;10(1):284. doi: 10.1186/s13287-019-1363-1.
17. Zhou Z, Long D, Hsu CC, Liu H, Chen L, Slavin B, Lin H, Li X, Tang J, Yiu S, Tuffaha S, Mao HQ. Nanofiber-reinforced decellularized amniotic membrane improves limbal stem cell transplantation in a rabbit model of corneal epithelial defect. Acta Biomater. 2019 Oct 1;97:310-320. doi: 10.1016/j.actbio.2019.08.027. Epub 2019 Aug 19.
18. Lin TC, Lin YY, Hsu CC, Yang YP, Yang CH, Hwang DK, Wang CY, Liu YY, Lo WL, Chiou SH, Peng CH, Chen SJ, Chang YL*. 2019 Jul.. Cell Transplant. [Epub ahead of print] (SCI)
19. Yang YP, Nguyen PNN, Lin TC, Yarmishyn AA, Chen WS, Hwang DK, Chiou GY, Lin TW, Chien CS, Tsai CY, Chiou SH, Chen SJ, Peng CH*, Hsu CC*. 2019 Jun. Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber's Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells. Cells. E625 (SCI)
20. Hsu CC*. 2019 Apr-Jun. Dendrite-like anterior stromal keratitis coinfected with Acanthamoeba and Pseudomonas in an orthokeratology contact lens wearer. Taiwan J Ophthalmol.131-133.
21. Hsu CC, Lin YY, Yang TC, Yarmishyn AA, Lin TW, Chang YL, Hwang DK, Wang CY, Liu YY, Lo WL, Peng CH, Chen SJ, Yang YP*. 2019 May. P3HT:Bebq2-Based Photovoltaic Device Enhances Differentiation of hiPSC-Derived Retinal Ganglion Cells. Int J Mol Sci. E2661. (SCI)
22. Kuo CY, Hsu CC*, Lin PY. 2019 May. Bilateral corneal geographic ulcers in a patient with eczema herpeticum. Kaohsiung J Med Sci. [Epub ahead of print]. (SCI)
23. Chen MJ, Chang YF, Kuo YS, Hsu CC, Ko YC, Liu CJ*. 2019 Apr. Macular ganglion cell-inner plexiform vs retinal nerve fiber layer measurement to detect early glaucoma with superior or inferior hemifield defects. J Chin Med Assoc. 335-339. (SCI)
24. Lo KJ, Huang YY, Hsu CC*. 2019 Mar. Synchysis scintillans mimicking phacolytic glaucoma in a traumatic eye. Kaohsiung J Med Sci.[Epub ahead of print]. (SCI)
25. Tsai DC, Huang N, Fang SY, Hsu CC, Lin PY, Chen SY, Liou YM, Chiu AW, Liu CJ*. 2019 Mar. Seasonal variation of refractive error change among young schoolchildren in a population-based cohort study in Taipei. Br J Ophthalmol. 343-348. (SCI)
26. Hwang DK#, Hsu CC#, Chang KJ#, Chao D, Sun CH, Jheng YC, Yarmishyn AA, Wu JC, Tsai CY, Wang ML, Peng CH, Chien KH, Kao CL, Lin TC, Woung LC, Chen SJ, Chiou SH*.2019 Jan. Artificial intelligence-based decision-making for age-related macular degeneration. Theranostics. 232-245. (SCI) (# equal co-first)
27. Lin TW, Chien Y, Lin YY, Wang ML, Yarmishyn AA, Yang YP, Hwang DK, Peng CH, Hsu CC, Chen SJ, Chien KH*. 2019 Jan. Establishing Liposome-Immobilized Dexamethasone-Releasing PDMS Membrane for the Cultivation of Retinal Pigment Epithelial Cells and Suppression of Neovascularization. Int J Mol Sci. E241. (SCI)
28. Chen MJ, Yang HY, Chang YF, Hsu CC, Ko YC, Liu CJ*. 2019 Jan. Diagnostic ability of macular ganglion cell asymmetry in Preperimetric Glaucoma. BMC Ophthalmol. 12. (SCI)
29. Yang HY, Chang YF, Hsu CC, Ko YC, Liu CJ, Chen MJ*. 2018 Nov. Macular ganglion cell asymmetry for detecting paracentral scotoma in early glaucoma. Clin Ophthalmol. 2253-2260.
30. Hsu YR, Huang JC, Tao Y, Kaburaki T, Lee CS, Lin TC, Hsu CC, Chiou SH*, Hwang DK*. 2019 Jan. Noninfectious uveitis in the Asia-Pacific region. Eye. 66-77. (SCI)
31. Lin H, Liu Y, Kambhampati SP, Hsu CC, Kannan RM*, Yiu SC*. 2018 Oct. Subconjunctival dendrimer-drug therapy for the treatment of dry eye in a rabbit model of induced autoimmune dacryoadenitis. Ocul Surf. 415-423. (SCI)
32. Chuang JH, Yarmishyn AA, Hwang DK, Hsu CC, Wang ML, Yang YP, Chien KH, Chiou SH, Peng CH*, Chen SJ*. 2018 May. Expression profiling of cell-intrinsic regulators in the process of differentiation of human iPSCs into retinal lineages. Stem Cell Res Ther. 140. (SCI)
33. Peng CH, Huang KC, Lu HE, Syu SH, Yarmishyn AA, Lu JF, Buddhakosai W, Lin TC, Hsu CC, Hwang DK, Shen CN, Chen SJ, Chiou SH*. 2018 May. Generation of induced pluripotent stem cells from a patient with X-linked juvenile retinoschisis. Stem Cell Res. 152-156. (SCI)
34. Hsu CC, Lu HE, Chuang JH, Ko YL, Tsai YC, Tai HY, Yarmishyn AA, Hwang DK, Wang ML, Yang YP, Chen SJ, Peng CH, Chiou SH*, Lin TC*. 2018 May. Generation of induced pluripotent stem cells from a patient with Best Dystrophy carrying 11q12.3 (BEST1 (VMD2)) mutation. Stem Cell Res. 134-138. (SCI)
35. Kuo CY, Chang YF, Chou YB, Hsu CC*, Lin PY, Liu CJ. 2017 Dec. Delayed onset of pressure-induced interlamellar stromal keratitis in a patient with recurrent uveitis: A case report. Medicine. e8958.(SCI)
36. Hou TY, Chen YC, Hsu CC*. 2017 Oct-Dec. Rapid resolution of stromal keratitis with the assistance of oral voriconazole in resistant acanthamoeba keratitis. Taiwan J Ophthalmol. 224-226
37. Lin TC, Hwang DK, Hsu CC, Peng CH, Wang ML, Chiou SH, Chen SJ*. 2017 Nov. Protective effect of metformin against retinal vein occlusions in diabetes mellitus - A nationwide population-based study. PLoS One. e0188136 (SCI)
38. Hsu CC, Huang N, Lin PY, Fang SY, Tsai DC, Chen SY, Tsai CY, Woung LC, Chiou SH, Liu CJ. 2017 Dec. Risk factors for myopia progression in second-grade primary school children in Taipei: a population-based cohort study. Br J Ophthalmol. 1611-1617. (SCI)
39. Lee CW, Fang SY, Tsai DC, Huang N, Hsu CC, Chen SY, Chiu AW, Liu CJ. 2017 Mar. Prevalence and association of refractive anisometropia with near work habits among young schoolchildren: The evidence from a population-based study. PLoS One. e0173519.(SCI)
40. Tsai DC, Fang SY, Huang N, Hsu CC, Chen SY, Chiu AW, Liu CJ*. 2016 Dec. Myopia Development Among Young Schoolchildren: The Myopia Investigation Study in Taipei. Invest Ophthalmol Vis Sci. 6852-6860. (SCI)
41. Hsu CC, Huang N, Lin PY, Tsai DC, Tsai CY, Woung LC, Liu CJ*. 2016 Nov. Prevalence and risk factors for myopia in second-grade primary school children in Taipei: A population-based study. J Chin Med Assoc. 625-632. (SCI)
42. Lin TC, Hung KH, Peng CH, Liu JH, Woung LC, Tsai CY, Chen SJ, Chen YT, Hsu CC*. 2015 Nov. Nanotechnology-based drug delivery treatments and specific targeting therapy for age-related macular degeneration. J Chin Med Assoc. 635-41.(SCI)
43. Lin TC, Chang HM, Hsu CC, Hung KH, Chen YT, Chen SY, Chen SJ*. 2015 Sep. Retinal prostheses in degenerative retinal diseases. J Chin Med Assoc. 501-5. (SCI)
44. Tsai DC, Lin LJ, Huang N, Hsu CC, Chen SY, Chiu AW, Liu CJ*. 2015 Sep-Oct. Study design, rationale and methods for a population-based study of myopia in schoolchildren: the Myopia Investigation study in Taipei. Clin Exp Ophthalmol.612-20. (SCI)
45. Wang LC, Hung KH, Hsu CC, Chen SJ, Li WY, Lin TC*. 2015 Jun. Assessment of retinal pigment epithelial cells in epiretinal membrane formation. J Chin Med Assoc. 370-3. (SCI)
46. Hsu CC, Chang HM, Lin TC, Hung KH, Chien KH, Chen SY, Chen SN, Chen YT*. 2015 Jun. Corneal neovascularization and contemporary antiangiogenic therapeutics. J Chin Med Assoc. 323-30. (SCI)
47. Chang HM*, Hung KH, Hsu CC, Lin TC, Chen SY. 2015 Mar. Using induced pluripotent stem cell-derived conditional medium to attenuate the light-induced photodamaged retina of rats. J Chin Med Assoc. 169-76. (SCI)
48. Hsu CC#, Peng CH#, Hung KH#, Lee YY, Lin TC, Jang SF, Liu JH, Chen YT, Woung LC, Wang CY, Tsa CY, Chiou SH, Chen SJ, Chang YL*. 2015 Oct. Stem Cell Therapy for Corneal Regeneration Medicine and Contemporary Nanomedicine for Corneal Disorders. Cell Transplant. 1915-30. (SCI). (# equal co-first)
49. Tsai IL, Hsu CC, Hung KH, Chang CW, Cheng YH*. 2015 Apr. Applications of biomaterials in corneal wound healing. J Chin Med Assoc. 212-7. (SCI)
50. Lin TC, Hsu CC, Chien KH, Hung KH, Peng CH, Chen SJ*. 2014 Nov. Retinal stem cells and potential cell transplantation treatments. J Chin Med Assoc. 556-61. (SCI)
51. Chang YC, Chang WC, Hung KH, Yang DM, Cheng YH, Liao YW, Woung LC, Tsai CY, Hsu CC, Lin TC, Liu JH, Chiou SH, Peng CH*, Chen SJ*. 2014 Aug. The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Front Aging Neurosci. 191.(SCI)
52. Hsu CC, Chen SJ*, Li AF, Lee FL. 2014 Sep. Systolic blood pressure, choroidal thickness, and axial length in patients with myopic maculopathy. J Chin Med Assoc.487-91(SCI)