Ophthalmic Plastic and Reconstructive surgeons
Our physicians are experts in diagnosis and treating functional disorders of the
eyelids, orbit, and lacrimal system, as well as improving the cosmetic appearance
around the eye. Our surgeons see patients with a variety of conditions that affect the
structures around the eye, including:

• Orbital tumors and inflammation
• Droopy eyelids (ptosis)
• Thyroid eye disease
• Obstructed or damaged tear drains
• Traumatic injuries to eyelids and orbital fractures
• Eyelid & conjunctival tumors and inflammation
• Dacryocystitis and canaliculitis

Meet Our Team

Studies led by our team

• Multidisciplinary approach in Immunoglobulin G4-related disease (IgG4-RD)
• Multidisciplinary approach in thyroid eye disease
• Muller's Muscle-Conjunctival Resection (MMCR) surgery in patients with droopy eyelid
• Navigational transmaxillary endoscopic approach for deep orbital tumors and orbital fractures
  
• Diagnosis and treatment for primary and plug-related canaliculitis
• Novel surgical technique in blepharoplasty

Published papers

 Immunoglobulin G4-related disease (IgG4-RD) 
1. Chou WY, Tsai CY, Tsai CC*. Long-Term Follow-Up in IgG4- Related Ophthalmic
Disease: Serum IgG4 Levels and Their Clinical Relevance. Journal of Personalized
Medicine. 2022;12:1963.
2. Yu WK, Tsai CC, Kao SC. Immunoglobulin G4-related Ophthalmic Disease. Taiwan
J Ophthalmol. 2018;8:9-14.
3. Wu YH, Wang LC, Yen SH, Yu WK, Kao SC, Kau HC, Tsai CC*, Liu CJ. Change of
Serum IgG4 in Patients with Ocular Adnexal Marginal Zone B Cell Lymphoma
Associated with IgG4-Related Ophthalmic Disease After Treatment. J Ocul
Pharmacol Ther. 2017;33:543-548.
4. Lin YH, Yen SH, Tsai CC*, Kao SC, Lee FL. Adjunctive orbital radiotherapy for
ocular adnexal IgG4-related disease: preliminary experience in patients
refractory or intolerant to corticosteroid therapy. Ocul Immunol Inflamm.
2015;23:162-7.
5. Yu WK, Kao SC, Yang CF, Lee FL, Tsai CC*. Ocular adnexal IgG4-related
disease: clinical features, outcome, and factors associated with response to
systemic steroids. Japanese Journal of Ophthalmology. 2015;59:8-13.

Navigational transmaxillary endoscopic approach for deep orbital
6. Wu CH, Ho YY, Liu TL, Wu TY, Cheng HC, Tsai CC. Navigational Transmaxillary
Endoscopic Approach for Inferomedial Tumors. Front Oncol. 2022;12:804070.
Multidisciplinary approach in thyroid eye disease
7. Wu SB, Hou TY, Kau HC, Tsai CC*. Effect of Pirfenidone on TGF-β1-Induced
Myofibroblast Differentiation and Extracellular Matrix Homeostasis of Human
Orbital Fibroblasts in Graves’ Ophthalmopathy. Biomolecules. 2021; 11:1424.
8. Yu WK, Hwang WL, Wang YC, Tsai CC,* Wei YH. Curcumin Suppresses TGF-1-
Induced Myofibroblast Differentiation and Attenuates Angiogenic Activity of
Orbital Fibroblasts. International Journal of Molecular Sciences, 2021;22,6829.
9. Hou TY, Wu SB, Kau HC, Tsai CC*. The Role of Oxidative Stress and
Therapeutic Potential of Antioxidants in Graves’ Ophthalmopathy. Biomedicines.
2021; 9:1871.
 

Diagnosis and treatment for primary and plug-related canaliculitis
10. Yeh TC, Hou TY, Huang YY, Yu WK, Tsai CC *. Plug-related canaliculitis: a rare or
underdiagnosed disease? Clinical and Experimental Optometry, 105(4):385-391.
11. Huang YY, Yu WK, Tsai CC*, Kao SC, Kau HC, Liu CJ. Clinical features,
microbiological profiles and treatment outcome of lacrimal plug-related
canaliculitis compared with those of primary canaliculitis. Br J Ophthalmol.
2016;100:1285-9.

Novel surgical technique in blepharoplasty
12. Chang YF, Tsai CC*, Kau HC, Liu CJ. Vertical-to-Horizontal Rotational
Myocutaneous Flap for Repairing Cicatricial Lower Lid Ectropion: A Novel
Surgical Technique. Biomed Res Int. 2017;2017:8614580.
Eye tumors
13. Huang YY, Hou TY, Yu WK, Tsai CC*, Kao S-C, Hsu WM, Liu JL. The Clinical Feature
and Treatment Outcome of Ocular Melanoma: A 34-Year Experience in a Tertiary
Referral Center. Cancers. 2021; 13(23):5926.
14. Huang YY, Liang WY, Tsai CC*, Kao SC, Yu WK, Kau HC, Liu CJ. Comparison
of the Clinical Characteristics and Outcome of Benign and Malignant Eyelid
Tumors: An Analysis of 4521 Eyelid Tumors in a Tertiary Medical Center.
Biomed Res Int. 2015;2015:453091.