NY Lee*, RL Ferris, A Psyrri, RI Haddad, M Tahara, J Bourhis, K Harrington, PM Chang, JC Lin, MA Razaq, MM Teixeira, J Lövey, J Chamois, A Rueda, C Hu, LA Dunn, MV Dvorkin, SD Beukelaer, D Pavlov, H Thurm, E Cohen.  Avelumab Plus Standard-of-Care Chemoradiotherapy Versus Chemoradiotherapy Alone in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Randomised, Double-Blind, Placebo-Controlled, Multicentre, Phase 3 Trial. Lancet Oncol 2021 Apr; 22(4): 450-62. (IF: 33.752; Oncology 4/244)

YH Luo, CH Chiu, CH Scott Kuo, TY Chou, YC Yeh, HS Hsu, SH Yen, YH Wu, JC Yang, BC Liao, TC Hsia, YM Chen*.  Lung Cancer in Republic of China. J Thorac Oncol 2021 Apr; 16(4): 519-27. (IF: 13.357; Respiratory System 3/64; Oncology 11/244)

DL Ou, CW Chen, CL Hsu, CH Chung, ZR Feng, BS Lee, AL Cheng, MH Yang*, C Hsu*.  Regorafenib Enhances Antitumor Immunity Via Inhibition of p38 Kinase/Creb1/Klf4 Axis in Tumor-Associated Macrophages. J Immunother Cancer 2021 Mar; 9(3): e001657. (IF: 10.252; Immunology 10/159; Oncology 16/244)

PH Chang, MC Chen, YP Tsai, GY Tan, PH Hsu, YM Jeng, YF Tsai, MH Yang, WW Hwang-Verslues*.  Interplay between Desmoglein2 and Hypoxia Controls Metastasis in Breast Cancer. Proc Natl Acad Sci U S A 2021 Jan; 118(3): e2014408118. (IF: 9.412; Multidisciplinary Sciences 8/71)

CT Shih, CW Shiau, YL Chen, LJ Chen, TI Chao, CY Wang*, CY Huang*, MH Hung*, KF Chen.  TD-92, A Novel Erlotinib Derivative, Depletes Tumor-Associated Macrophages in Non-Small Cell Lung Cancer via Down-Regulation of CSF-1R and Enhances the Anti-Tumor Effects of Anti-PD-1. Cancer Lett 2021 Feb; 498(): 142-51. Epub 2020 Nov. (IF: 7.360; Oncology 30/244)

N Boku*, T Satoh, MH Ryu, Y Chao, K Kato, HC Chung, JS Chen, K Muro, WK Kang, KH Yeh, T Yoshikawa, SC Oh, LY Bai, T Tamura, KW Lee, Y Hamamoto, JG Kim, K Chin, DY Oh, K Minashi, JY Cho, M Tsuda, T Nishiyama, LT Chen, YK Kang.  Nivolumab in Previously Treated Advanced Gastric Cancer (ATTRACTION-2): 3-Year Update and Outcome of Treatment Beyond Progression with Nivolumab. Gastric Cancer 2021 Mar. [Epub ahead of print] (IF: 7.088; Oncology 32/244; Gastroenterology & Hepatology 14/88)

BY Ryoo, P Merle, AS Kulkarni, AL Cheng, M Bouattour, HY Lim, V Breder, J Edeline, Y Chao, S Ogasawara, T Yau, M Garrido, SL Chan, B Daniele, JM Norquist, E Chen, AB Siegel, AX Zhu, RS Finn, M Kudo*.  Health-Related Quality-of-Life Impact of Pembrolizumab versus Best Supportive Care in Previously Systemically Treated Patients with Advanced Hepatocellular Carcinoma: KEYNOTE-240. Cancer 2021 Mar; 127(6): 865-74. Epub 2020 Nov. (IF: 5.772; Oncology 46/244)

YF Tsai, CC Huang, YS Lin, CY Hsu, CP Huang, CY Liu, JH Chiu*, LM Tseng.  Interleukin 17A Promotes Cell Migration, Enhances Anoikis Resistance, and Creates a Microenvironment Suitable for Triple Negative Breast Cancer Tumor Metastasis. Cancer Immunol Immunother 2021 Jan. [Epub ahead of print] (IF: 5.442; Oncology 51/244; Immunology 34/159)

LM Tseng, PJ Lien, CY Huang, YF Tsai, TC Chao, SM Huang*.  Developing a Web-Based Shared Decision-Making Tool for Fertility Preservation Among Reproductive-Age Women with Breast Cancer: An Action Research Approach. J Med Internet Res 2021 Mar; 23(3): e24926. (IF: 5.034; Health Care Sciences & Services 5/102; Medical Informatics 2/27)

YS Huang, WC Hsu, CH Lin, SN Lo, CN Cheng, MS Lin, TW Lee, CH Chang*, KL Lan*.  Bi-Functional Radiotheranostics of 188 Re-Liposome-Fcy-hEGF for Radio- and Chemo-Therapy of EGFR-Overexpressing Cancer Cells. Int J Mol Sci 2021 Feb; 22(4): 1902. (IF: 4.556; Biochemistry & Molecular Biology 74/297; Chemistry, Multidisciplinary 48/177)

WT Wu, WY Lin, YW Chen, CF Lin, HH Wang, SH Wu, YY Lee*.  New Era of Immunotherapy in Pediatric Brain Tumors: Chimeric Antigen Receptor T-Cell Therapy. Int J Mol Sci 2021 Feb; 22(5): 2404. (IF: 4.556; Biochemistry & Molecular Biology 74/297; Chemistry, Multidisciplinary 48/177)

YF Hu*, CH Wu, TC Lai, YC Chang, MJ Hwang, TY Chang, CH Weng, PM Chang, CH Chen, D Mochly-Rosen, CY Huang, SA Chen.  ALDH2 Deficiency Induces Atrial Fibrillation through Dysregulated Cardiac Sodium Channel and Mitochondrial Bioenergetics: A Multi-Omics Analysis. Biochim Biophys Acta Mol Basis Dis 2021 May; 1867(5): 166088. Epub 2021 Jan. (IF: 4.352; Biophysics 14/71; Biochemistry & Molecular Biology 82/297)

PW Chan, JH Chiu, N Huang, CM Chen, H Yu, CY Liu*, CH Hsu*.  Influence of Traditional Chinese Medicine on Medical Adherence and Outcome in Estrogen Receptor (+) Breast Cancer Patients in Taiwan: A Real-World Population-Based Cohort Study. Phytomedicine 2021 Jan; 80(): 153365. Epub 2020 Oct. (IF: 4.268; Integrative & Complementary Medicine 2/28; Plant Sciences 23/234; Pharmacology & Pharmacy 50/271; Chemistry, Medicinal 13/61)

NJ Chiang, LT Chen, YS Shan, CN Yeh*, MH Chen*.  Development of Possible Next Line of Systemic Therapies for Gemcitabine-Resistant Biliary Tract Cancers: A Perspective from Clinical Trials. Biomolecules 2021 Jan; 11(1): 97. (IF: 4.082; Biochemistry & Molecular Biology 98/297)

CC Huang, YF Tsai, CY Liu, TC Chao, PJ Lien, YS Lin, CJ Feng, JH Chiu, CY Hsu, LM Tseng*.  Comprehensive Molecular Profiling of Taiwanese Breast Cancers Revealed Potential Therapeutic Targets: Prevalence of Actionable Mutations Among 380 Targeted Sequencing Analyses. BMC Cancer 2021 Feb; 21(1): 199. (IF: 3.150; Oncology 129/244)

CA Liu, IC Lee, RC Lee, JL Chen, Y Chao, MC Hou, YH Huang*.  Prediction of Survival According to Kinetic Changes of Cytokines and Hepatitis Status Following Radioembolization with Yttrium-90 Microspheres. J Formos Med Assoc 2021 Apr; 120(4): 1127-36. Epub 2020 Sep. (IF: 3.008; Medicine, General & Internal 42/165)

KH Yeh, TS Yang, TC Hsu, WT Chen, HH Chen, HW Teng, BW Lin, FC Kuan, FF Chiang, CW Duann, YS Li, MT Lin, S Fiala-Buskies, M Ducreux, JY Wang*.  Real-World Evidence of the Safety and Effectiveness of Regorafenib in Taiwanese Patients with Metastatic Colorectal Cancer: CORRELATE Taiwan. J Formos Med Assoc 2021 Jan. [Epub ahead of print] (IF: 3.008; Medicine, General & Internal 42/165)

GC Chang*, DC Lam, CM Tsai, YM Chen, JY Shih, S Aggarwal, S Wang, SW Kim, YC Kim, I Wahid, R Li, DW Lim, V Sriuranpong, RT Chan, RM Lorence, P Carriere, C Raabe, A Cseh, K Park.  Experience from Asian Centers in A Named-Patient-Use Program for Afatinib in Patients with Advanced Non-Small-Cell Lung Cancer Who Had Progressed Following Prior Therapies, Including Patients with Uncommon EGFR Mutations. Int J Clin Oncol 2021 Mar. [Epub ahead of print] (IF: 2.879; Oncology 147/244)

CY Kuo, CC Lee, YL Lee, SC Liou, JC Lee, EC Su*, YW Chen*.  Visual Light Perceptions Caused by Medical Linear Accelerator: Findings of Machine-Learning Algorithms in a Prospective Questionnaire-Based Case-Control Study. PLoS One 2021 Feb; 16(2): e0247597. (IF: 2.740; Multidisciplinary Sciences 27/71)

MJ Ahn, D Chirovsky*, H Kuyas, V Auclair, S Abounit, S Joo, R Shah, MH Yang.  Global Longitudinal Assessment of Treatment Outcomes in Recurrent/Metastatic Nasopharyngeal Carcinoma: GLANCE-NPC Study. Future Oncol 2021 Feb. [Epub ahead of print] (IF: 2.660; Oncology 160/244)

TH Chen, WS Chen, JK Jiang, SH Yang, HS Wang, SC Chang, YT Lan, CC Lin, HH Lin, SC Huang, HH Cheng, GY Chau, CY Hsia, HJ Lei, SC Chou, Y Chao, HW Teng*.  Effect of Primary Tumor Location on Postmetastasectomy Survival in Patients with Colorectal Cancer Liver Metastasis. J Gastrointest Surg 2021 Mar; 25(3): 650-61. Epub 2020 Nov. (IF: 2.573; Surgery 65/210; Gastroenterology & Hepatology 61/88)

CH Liu, LH Li, ML Chang, WF Kao, CK How, JI Lai, YK Lin, YH Chiu, WH Chang.  Electrical Cardiometry and Cardiac Biomarkers in 24-h and 48-h Ultramarathoners. Int J Sports Med 2021 Mar. [Epub ahead of print] (IF: 2.556; Sport Sciences 29/85)

TH Chen, PM Chang, MH Yang*.  Combination of Pembrolizumab and Lenvatinib is a Potential Treatment Option for Heavily Pre-Treated Recurrent And Metastatic Head and Neck Cancer. J Chin Med Assoc 2021 Jan. [Epub ahead of print] (IF: 2.170; Medicine, General & Internal 63/165)

YP Hung, YY Shao, JM Lee, C Hsu, CH Hsu, MH Yang*, Y Chao*.  Potential of Circulating Immune Cells as Biomarkers of Nivolumab Treatment Efficacy for Advanced Hepatocellular Carcinoma. J Chin Med Assoc 2021 Feb; 84(2): 144-50. Epub 2021 Jan. (IF: 2.170; Medicine, General & Internal 63/165)

CY Chang, CY Wei, PH Chen, MC Hou, Y Chao, GY Chau, RC Lee, YH Huang, YH Su, JC Wu, CW Su*.  The Role of Albumin-Bilirubin Grade in Determining the Outcomes of Patients with Very Early Stage Hepatocellular Carcinoma. J Chin Med Assoc 2021 Jan. [Epub ahead of print] (IF: 2.170; Medicine, General & Internal 63/165)

LY Lin, SC Lin, HJ Lee, ST Chen, HM Wu, YW Chen, HH Chen, CB Luo, WY Guo, FC Chang*.  MRI Findings for Diagnosis of Postoperative Foreign Body Granulomas Versus Recurrent Tumours in Patients of Brain Tumour Surgery. Clin Radiol 2021 Apr; 76(4): 316.e19-28. Epub 2021 Feb. (IF: 2.118; Radiology, Nuclear Medicine & Medical Imaging 74/134)

PJ Chien*, LT Hung, LW Wang, MH Yang, PY Chu*.  Oncologic Results and Quality of Life in Patients with T3 Glottic Cancer after Transoral Laser Microsurgery. Eur Arch Otorhinolaryngol 2021 Jan. [Epub ahead of print] (IF: 1.809; Otorhinolaryngology 19/42)