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杭仁釩 (Hang, Jen-Fan)


  • 學歷
    • 長庚大學醫學系
  • 經歷
    • 2017- 迄今 臺北榮民總醫院病理檢驗部 主治醫師
    • 2021- 迄今 國立陽明交通大學醫學系 助理教授
    • 2015- 迄今 台灣臨床細胞學會 理事
    • 2020- 迄今 台灣病理學會 理事
    • 2010- 2013 臺北榮總病理部 住院醫師
    • 2013- 2014 臺北榮總病理部 總醫師
    • 2014- 2015 臺北榮總病理部 泌尿病理 研究員
    • 2015- 2016 臺北榮總病理部 神經病理 研究員
    • 2016- 2017 美國約翰霍普金斯醫院病理部 細胞病理 研究員
    • 2014- 2017 台灣病理學會 副秘書長
    • 2017- 2020 台灣病理學會 秘書長
  • 醫療專長
    1. 細胞病理
    2. 甲狀腺病理
    3. 泌尿病理
    4. 頭頸病理
    5. 神經病理
  • 證照
  • 語言專長


  1. Holliday D Jr, Mehrad M, Ely KA, Tong F, Wang X, Hang JF, Kuo YJ, Velez-Torres JM, Lott-Limbach A, Lewis JS Jr. Sinonasal adenosquamous carcinoma - morphology and genetic drivers including low- and high-risk human papillomavirus mRNA, DEK::AFF2 fusion, and MAML2 rearrangement. Head Neck Pathol. 2023 Feb 28. [Online ahead of print]
  2. Chen CJ*, Hang JF*, Chen YA, Lin SJ, Chiu HM, Hsu CY, Lai CR, Yang CS. The diagnostic utility of trichorhinophalangeal syndrome type 1 immunohistochemistry for metastatic breast carcinoma in effusion cytology specimens. Cancer Cytopathol. 2022 Nov 18. [Online ahead of print] (*the first two authors contributed equally)
  3. Lin SY, Hang JF, Lai CR, Chan IS, Shih YC, Jiang LY, Chang YH, Chen YJ. Loss of major histocompatibility complex class I, CD8+ tumor-infiltrating lymphocytes, and PD-L1 expression in ovarian clear cell carcinoma. Am J Surg Pathol. 2023 Jan 1;47(1):124-130.
  4. Tang CY, Hang JF, Hung YP, Chiu NC, Lai JI, Chen MH, Liu CY, Yang MH, Chao Y, Chang PM. A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years. Cancer Med. 2023 Jan;12(2):1090-1101.
  5. Ou YC, Tsao TY, Chang MC, Lin YS, Yang WL, Hang JF, Li CB, Lee CM, Yeh CH, Liu TJ. Evaluation of an artificial intelligence algorithm for assisting the Paris System in reporting urinary cytology: a pilot study. Cancer Cytopathol. 2022 Nov;130(11):872-880.
  6. Kuo YJ, Lewis JS Jr, Truong T, Yeh YC, Chernock RD, Zhai C, Chen YA, Hongo T, Lee CK, Shi Q, Velez Torres JM, Geromes AB, Chu YH, Hsieh MS, Yamamoto H, Weinreb I, Hang JF*. Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract. Mod Pathol. 2022 Nov;35(11):1587-1595. (*Corresponding author)
  7. Hang JF*, Lee JJL, Nga ME, Higuchi K, Hirata Y, Wu HH, Allison DB, Gilbert JD, Lin O, Saieg M, de Arruda AF, Chen YA, Huang EC, Manucha V*. Multi-institutional validation of a modified scheme for subcategorizing salivary gland neoplasm of uncertain malignant potential (SUMP). Cancer Cytopathol. 2022 Jul;130(7):511-522. (*Corresponding author)
  8. Hang JF, Yuan CT, Chang KC, Wang RC, Chen BJ, Hsieh PP, Huang WT, Chuang WY, Chen TW, Yeh YC, Lin SY, Hsiao CH, Chou SC, Tseng CE, Pan ST, Chang SL, Chuang SS. Targeted next-generation sequencing reveals a wide morphological and immunophenotypic spectrum of monomorphic epitheliotropic intestinal T-cell lymphoma. Am J Surg Pathol. 2022 Sep 1;46(9):1207-1218.
  9. Liao PH, Chiang HL, Shun CT, Hang JF, Chiu HM, Wu MS, Lin CH. Colonic leucine-rich repeat kinase 2 expression is increased and associated with disease severity in patients with Parkinson's disease. Front Aging Neurosci. 2022 Jan 17;13:819373.
  10. Lee YC, Hsu CY, Lai CR, Hang JF*. NTRK-rearranged papillary thyroid carcinoma demonstrates frequent subtle nuclear features and indeterminate cytologic diagnoses. Cancer Cytopathol. 2022 Feb;130(2):136-143. (*Corresponding author)
  11. Liu CY, Chen CC, Bychkov A, Agarwal S, Zhu Y, Hang JF, Lai CR, Na HY, Park SY, Li W, Liu Z, Jain D, Suzuki A, Hirokawa M, Chia N, Nga ME, Jitpasutham T, Keelawat S, Satoh S, Gunawardena D, Kumarasinghe P, Jung CK, Kakudo K. Constitutive cytomorphologic features of medullary thyroid carcinoma using different staining methods. Diagnostics (Basel). 2021 Aug 2;11(8):1396.
  12. Kuo YJ, Lewis JS Jr, Zhai C, Chen YA, Chernock RD, Hsieh MS, Lan MY, Lee CK, Weinreb I, Hang JF*. DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology. Mod Pathol. 2021 Oct;34(10):1820-1830. (*Corresponding author)
  13. Lin SY, Wang YH, Hsu CY, Chen YJ, Lai CR, Hang JF*. Analytical validation of HER2 immunohistochemistry using A0485 versus 4B5 antibodies and breast versus gastric scoring guidelines in ovarian clear cell carcinoma. Histopathology. 2021 Nov;79(5):758-767. (*Corresponding author)
  14. Chang HY, Hang JF*, Wu CY, Lin TP, Chung HJ, Chang YH, Pan CC. Clinicopathological and molecular characterization of papillary renal neoplasm with reverse polarity and its renal papillary adenoma analogue. Histopathology. 2021 Jun;78(7):1019-1031. (*Corresponding author)
  15. Lin YY, Lin LY, Hang JF, Lin CH, Ho HL, Chou TY. Programmed death-ligand 1 (PD-L1)/thyroid transcription factor-1 double immunohistochemical staining facilitates scoring of tumor PD-L1 expression in cytopathology specimens from lung adenocarcinoma patients. Cancer Cytopathol. 2021 Feb;129(2):148-155.
  16. Lin SY, Hang JF, Lin YY, Lai CR, Ho HL, Chou TY. Diffuse Intratumoral stromal inflammation in ovarian clear cell carcinoma is associated with loss of mismatch repair protein and high PD-L1 expression. Int J Gynecol Pathol. 2021 Mar 1;40(2):148-155.
  17. Lee YC, Chen JY, Huang CJ, Chen HS, Yang AH, Hang JF*. Detection of NTRK1/3 rearrangements in papillary thyroid carcinoma using immunohistochemistry, fluorescent in situ hybridization, and next-generation sequencing. Endocr Pathol. 2020 Dec;31(4):348-358. (*Corresponding author)
  18. Liu CY, Bychkov A, Agarwal S, Zhu Y, Hang JF, Lai CR, Na HY, Li W, Liu Z, Jain D, Suzuki A, Hirokawa M, Chia N, Nga ME, Jitpasutham T, Keelawat S, Park SY, Satoh S, Chen CC, Gunawardena D, Kumarasinghe P, Jung CK, Kakudo K. Cytologic diagnosis of medullary thyroid carcinoma in the Asia-Pacific region. Diagn Cytopathol. 2021 Jan;49(1):60-69.
  19. Chowsilpa S, Jones R, Hang JF, Ali SZ. Characterization of “suspicious for malignancy” for non-papillary carcinoma diagnoses on thyroid fine-needle aspiration. J Am Soc Cytopathol. 2020 Jul 15:S2213-2945(20)30117-4.
  20. Lai WA, Liu CY, Lin SY, Chen CC, Hang JF*. Characterization of driver mutations in anaplastic thyroid carcinoma identifies RAS and PIK3CA mutations as negative survival predictors. Cancers (Basel). 2020 Jul 20;12(7):1973. (*Corresponding author)
  21. Kuroda N, Trpkov K, Gao Y, Tretiakova M, Liu YJ, Ulamec M, Takeuchi K, Agaimy A, Przybycin C, Magi-Galluzzi C, Fushimi S, Kojima F, Sibony M, Hang JF, Pan CC, Yilmaz A, Siadat F, Sugawara E, Just PA, Ptakova N, Hes O. ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217. Mod Pathol. 2020 Dec;33(12):2564-2579.
  22. Zhu Y, Li Y, Jung CK, Song DE, Hang JF, Liu Z, Jain D, Lai CR, Hirokawa M, Kakudo K, Bychkov A. Histopathologic assessment of capsular invasion in follicular thyroid neoplasms: An observer variation study. Endocr Pathol. 2020 Jun;31(2):132-140.
  23. Lai WA, Hang JF*, Liu CY, Bai Y, Liu Z, Gu H, Hong S, Pyo JY, Jung CK, Kakudo K, Bychkov A. PAX8 expression in anaplastic thyroid carcinoma is less than those reported in early studies: a multi-institutional study of 182 cases using the monoclonal antibody MRQ-50. Virchows Arch. 2020 Mar;476(3):431-437. (*Corresponding author)
  24. Wu PF, Hang JF, Strong C, Chen SJ, Lin LY, Chen SS, Lai CR, Ku SW, Lee MH. Anal human papillomavirus and its associations with abnormal anal cytology among men who have sex with men. Sci Rep. 2020 Feb 21;10(1):3165. 
  25. Alruwaii F, Hang JF, Zeng BR, Cramer HM, Lai CR, De la Sancha C, Wu HH. Risk of malignancy in "atypia of undetermined significance" category of salivary gland fine-needle aspiration: A bi-institutional experience. Diagn Cytopathol. 2020 Feb;48(2):138-143
  26. Wang YH, Hang JF*, Wen CH, Liao KC, Lee WY, Lai CR. Diagnostic agreement for high-grade urothelial cell carcinoma in atypical urine cytology: A nationwide survey reveals a tendency for overestimation in specimens with an N/C ratio approaching 0.5. Cancers (Basel). 2020 Jan 22;12(2):272. (*Corresponding author)
  27. Sahli ZT, Sharma AK, Canner JK, Karipineni F, Ali O, Kawamoto S, Hang JF, Mathur A, Ali SZ, Zeiger MA, Sheth S. TIRADS Interobserver variability among indeterminate thyroid nodules: A single-institution study. J Ultrasound Med. 2019 Jul;38(7):1807-1813.
  28. Wu HH, Alruwaii F, Zeng BR, Cramer HM, Lai CR, Hang JF*. The application of the Milan system for reporting salivary gland cytopathology: A retrospective 12-year bi-institutional study. Am J Clin Pathol. 2019 May 3;151(6):613-621. (*Corresponding author)
  29. Sahli ZT, Karipineni F, Hang JF, Canner JK, Mathur A, Prescott JD, Sheth S, Ali SZ, Zeiger MA. The association between the ultrasonography TIRADS classification system and surgical pathology among indeterminate thyroid nodules. Surgery. 2019 Jan;165(1):69-74.
  30. Hang JF*, Alruwaii F, Zeng BR, Lai CR, Wu HH. Subtyping salivary gland neoplasm of uncertain malignant potential based on cell type demonstrates differential risk of malignancy. Cancer Cytopathol. 2018 Nov;126(11):924-933. (*Corresponding author)
  31. Hang JF, Westra WH, Zhou AG, Cooper DS, Ali SZ. The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the rate of malignancy for atypia of undetermined significance subcategories. Cancer Cytopathol. 2018 May;126(5):309-316.
  32. Bishop JA, Andreasen S, Hang JF, Bullock MJ, Chen TY, Franchi A, Garcia JJ, Gnepp DR, Gomez-Fernandez CR, Ihrler S, Kuo YJ, Lewis JS Jr, Magliocca KR, Pambuccian S, Sandison A, Uro-Coste E, Stelow E, Kiss K, Westra WH. HPV-related multiphenotypic sinonasal carcinoma: An expanded series of 49 cases of the tumor formerly known as HPV-related carcinoma with adenoid cystic carcinoma-like features. Am J Surg Pathol. 2017 Dec;41(12):1690-1701.
  33. Hang JF, Hsieh MS, Li WY, Chen JY, Lin SY, Liu SH, Pan CC, Kuo YJ. Human papillomavirus-related carcinoma with adenoid cystic-like features: A series of 5 cases expanding the pathologic spectrum. Histopathology. 2017 Dec;71(6):887-896.
  34. Hang JF, Charu V, Zhang ML, VandenBussche CJ. Digital image analysis supports a nuclear-to-cytoplasmic ratio cutoff value of 0.5 for atypical urothelial cells. Cancer Cytopathol. 2017 Sep;125(9):710-716.
  35. Hang JF, Westra WH, Cooper DS, Ali SZ. The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on the performance of the Afirma gene expression classifier. Cancer Cytopathol. 2017 Sep;125(9):683-691.
  36. Hang JF, Siddiqui MT, Ali SZ. Fine needle aspiration of langerhans cell histiocytosis: A cytopathologic study of 37 cases. Acta Cytol. 2017;61(2):96-102.
  37. Hang JF, Lilo MT, Bishop JA, Ali SZ. Diagnostic accuracy of fine needle aspiration in thyroid nodules arising in patients with Graves disease. Acta Cytol. 2017;61(2):117-124.
  38. Hang JF, Hsu CY, Lin SC, Wu CC, Lee HJ, Ho DM. Thyroid transcription factor-1 distinguishes subependymal giant cell astrocytoma from its mimics and supports its cell origin from the progenitor cells in the medial ganglionic eminence. Mod Pathol. 2017 Mar;30(3):318-328.
  39. Hang JF, Li AF, Chang SC, Liang WY. Immunohistochemical detection of BRAF V600E mutant protein in colorectal cancers in Taiwan is highly concordant with the molecular test. Histopathology. 2016 Jul;69(1):54-62.
  40. Lai CR, Hsu CY, Hang JF, Li AF. The diagnostic value of routine Papanicolaou smears for detecting endometrial cancers: An update. Acta Cytol. 2015;59(4):315-8.
  41. Hang JF, Liang WY, Hsu CY, Lai CR. Integrating web-based whole slide imaging system and online questionnaires in a national cytopathology peer-comparison educational program in Taiwan. Acta Cytol. 2015;59(3):278-83.
  42. Cheng CH, Hang JF, Tsau YK, Lin TY. Nephromegaly is a significant risk factor for renal scarring in children with first febrile urinary tract infections. J Urol. 2011 Dec;186(6):2353-7.