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▍研究室
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毒物與代謝研究室

TEL: +886-2-28712121*83547
E-mail: [email protected]
主持人：鄒瀚興
《學歷》

國立陽明大學 環境與職業衛生研究所 博士 (現國立陽明交通大學)

國立陽明大學 環境與職業衛生研究所 碩士 (現國立陽明交通大學)
《現職》

2026/03-迄今  臺北榮民總醫院 醫學研究部  高級助理研究員

2021/08-迄今  國立陽明交通大學 藥物科學院 食品安全及健康風險評估研究所 兼任助理教授

2021/03-迄今  社團法人台灣生醫品質保證協會 秘書長
《經歷》

2021/04-2026/02  元萃數據科技股份有限公司 (金萬林子公司)  專案經理

2020/02-2021/03  國立陽明交通大學 藥物科學院 食品安全及健康風險評估研究所  專案助理教授

2020/08-2021/02  社團法人台灣生醫品質保證協會  理事

2020/02-2020/12  國家衛生研究院論壇 國家衛生福利科技政策研究論壇  議題委員

2019/03-2020/01  臺北榮民總醫院 內科部-臨床毒物與職業醫學科  博士後研究員
《獲獎》

•  IUTOX Best Poster Award 1st place.
XIV International Congress of Toxicology (Mexico, 2016)

•  優秀論文指導獎-論文佳作 (題目:探討丙烯醛在人類大腸癌之中的機制)
「2021年第三屆優秀學位論文獎」社團法人台灣建築醫學學會 (台灣，2021)  
《專書》

新興菸品健康危害研議，中華民國110年11月出版
《專長領域》
  1. 毒理學 Toxicology
  2. 代謝體學 Metabolomics
  3. 化學分析 chemical analysis
  4. 食品安全 Food Safety
  5. 環境衛生學 Environmental Health
  6. 公共衛生學 Public Health
  7. 醫療器材法規 Medical Device
  8. 品質保證 Quality Assurance
《研究著作》

期刊論文

  1. Hsiang-Tsui Wang, Ping-Huai Wang, Chun-Yu Chen, Tsung-Yun Liu, Han-Hsing Tsou* (2025). Comparison of carbonyls and tobacco-specific nitrosamines in aerosols of heated tobacco products and conventional cigarette smoke using both targeted and untargeted analytical methods. Regulatory Toxicology and Pharmacology, 105786. (SCIE) *Corresponding author 台灣首篇加熱菸研究及新聞報導
  2. Zumbi, Crystal Ngofi, Hailey Hei Tung Choi, Huai-Syuan Huang, Suraphan Panyod, Tse-Wen Wang, Shyh-Jer Huang, Han-Hsing Tsou, Chi-Tang Ho, Lee-Yan Sheen (2025). Amino acid metabolites profiling in unpredictable chronic mild stress-induced depressive rats and the protective effects of Gastrodia elata Blume and Gastrodin. Journal of Ethnopharmacology, 337, 118906. (SCIE)
  3. Wen-Sheng Liu, Shih-Shin Liang, Mei-Mei Cheng, Ming-Tsan Wu, Szu-Yuan Li, Tien-Tien Cheng, Tsung-Yun Liu, Ching-Yao Tsai, Yen-Ting Lai, Chien-Hung Lin#, Hsiang-Tsui Wang#, Han-Hsing Tsou#* (2024). How renal toxins respond to renal function deterioration and oral toxic adsorbent in pH-controlled releasing capsule. Environmental Toxicology, 39(7), 3930-3943. (SCIE) *Corresponding author
  4. Cheng‑Wei Ho, Pei‑Ying Chen, Yi-Ting Liao, Yen-Fu Cheng, Han-Hsing Tsou, Tsung‑Yun Liu, Kung-Hao Liang* (2024). Uncovering the microbiome landscape in sashimi delicacies. Scientific Reports, 14(1), 5454. (SCIE)
  5. Wen-Sheng Liu, Chien-Hung Lin, Ann Charis Tan, Yen-Ting Lai, Tsung-Yun Liu, Hsiang-Lin Chan, Szu-Yuan Li, Chun-Fan Chen, Yung-Tai Chen, Tz-Heng Chen, Fan-Yu Chen, Yang Ho, Han-Hsing Tsou*, Chih-Ching Lin* (2023). The Associations between Erythropoietic Response with Inflammation Markers and Perfluorinated Chemicals in Hemodialysis Patients. Healthcare, 11(3), 442. (SCIE) *Co-corresponding author
  6. Wen-Sheng Liu, Chien-Hung Lin, Ching-Yao Tsai, Hsiang-Tsui Wang, Szu-Yuan Li, Tsung-Yun Liu, Ann Charis Tan, Han-Hsing Tsou#, Kuo-Hsien Tseng#, Chih-Ching Lin#* (2023). Double Filtration Plasmapheresis with Polyvinyl Alcohol-Based Membrane Lowers Serum Inflammation and Toxins in Patients with Hyperlipidemia. Bioengineering, 10(1), 89. (SCIE) *Co-corresponding author
  7. Yen-Ting Lai#, Hsiao-Ling Huang, City C. Hsieh, Chien-Hung Lin, Jung-Cheng Yang, Han-Hsing Tsou, Chih-Ching Lin, Szu-Yuan Li, Hsiang-Lin Chan#, Wen-Sheng Liu* (2023). The Effects of Yoga Exercise on Blood Pressure and Hand Grip Strength in Chronic Stroke Patients: A Pilot Controlled Study. International Journal of Environmental Research and Public Health, 20(2), 1108. (SCIE)
  8. Han-Hsing Tsou#, Ping-Huai Wang#, Tzu-Hsin Ting, Yueh-Hsin Ping, Tsung-Yun Liu, Hsiao-Wei Cheng, Hsiang-Tsui Wang* (2022). Effect of heated tobacco products and traditional cigarettes on pulmonary toxicity and SARS-CoV-2-induced lung injury. Toxicology, 479, 153318. (SCIE) *Co-first author
  9. Zhen-Jie Tong, Chin-Wei Kuo, Po-Cheng Yen, Chih-Ching Lin, Ming-Tsun Tsai, Shing-Hwa Lu, Yi-Ping Chang, Wen-Sheng Liu, Han-Hsing Tsou, Hsiao-Wei Cheng, Hsiang-Tsui Wang* (2022). Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo. European Journal of Endocrinology, 187(4), 579-592. (SCIE)
  10. Wen-Sheng Liu, Chien-Hung Lin, Szu-Yuan Li, Chih-Ching Lin, Tsung-Yun Liu, Ann Charis Tan, Han-Hsing Tsou*, Hsiang-Lin Chan*, Yen-Ting Lai* (2022). Perfluorooctanesulfonate Can Cause Negative Bias in Creatinine Measurement in Hemodialysis Patients Using Polysulfone Dialysis Membranes. Membranes, 12(8), 778. (SCIE) *Co-corresponding author
  11. Yen-Ting Lai, Chien-Hung Lin, City C. Hsieh, Jung-Cheng Yang, Han-Hsing Tsou, Chih-Ching Lin, Szu-Yuan Li, Hsiang-Lin Chan#, Wen-Sheng Liu#* (2022). Combining Yoga Exercise with Rehabilitation Improves Balance and Depression in Patients with Chronic Stroke: A Controlled Trial. Applied Sciences, 12(2), 922. (SCIE)
  12. Chia-Ling Weng, Chih-Chiang Chen, Han-Hsing Tsou, Tsung-Yun Liu, Hsiang-Tsui Wang* (2022). Areca nut procyanidins prevent ultraviolet light B-induced photoaging via suppression of cyclooxygenase-2 and matrix metalloproteinases in mouse skin. Drug and Chemical Drug and Chemical Toxicology, 45(1), 353-359. (SCIE)
  13. Han-Hsing Tsou#, Hong-Chieh Tsai#, Chiao-Ting Chu, Hsiao-Wei Cheng, Chung-Ji Liu, Chien-Hung Lee, Tsung-Yun Liu, Hsiang-Tsui Wang* (2021). Cigarette Smoke Containing Acrolein Upregulates EGFR Signaling Contributing to Oral Tumorigenesis In Vitro and In Vivo. Cancers, 13(14), 3544. (SCIE) *Co-first author
  14. Hong-Chieh Tsai, Han-Hsing Tsou, Chun-Chi Lin, Shao-Chen Chen, Hsiao-Wei Cheng, Tsung-Yun Liu, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Hao-Wei Teng* & Hsiang-Tsai Wang* (2021). Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway. Scientific Reports, 11(1), 12590. (SCIE)
  15. Han-Hsing Tsou, Hsiao-Tung Ko, Chia-Tzu Chen, Tse-Wen Wang, Chien-Hung Lee, Tsung-Yun Liu, Hsiang-Tsui Wang* (2019). Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Environmental Pollution, 251, 13-21. (SCIE) *First author
  16. Han-Hsing Tsou, Chih-Hung Hu, Chung-Ji Liu, Chien-Hung Lee, Tsung-Yun Liu, Hsiang-Tsui Wang* (2019). Acrolein is involved in the synergistic potential of cigarette smoking and betel quid chewing-related human oral cancer. Cancer Epidemiology, Biomarkers & Prevention, 28(5), 954-962. (SCIE) *First author
  17. Tse-Wen Wang, Jin-Hui Liu, Han-Hsing Tsou, Tsung-Yun Liu, Hsiang-Tsui Wang* (2019). Identification of acrolein metabolites in human buccal cells, blood, and urine after consumption of commercial fried food. Food Science & Nutrition, 7(5), 1668-1676. (SCIE)
  18. Ting-Ying Laio, Chih-Chun Chen, Han-Hsing Tsou, Tsung-Yun Liu, Hsiang-Tsui Wang* (2019). Acute and chronic exposure of toluene induces genotoxicity in different regions of the brain in normal and allergic mouse models. Neurotoxicity research, 36(4), 669-678. (SCIE)
  19. Wen-Sheng Liu, Hsiang Lin Chan, Yen-Ting Lai, Chih-Ching Lin, Szu-Yuan Li, Chih-Kuang Liu, Han-Hsing Tsou*, Tsung-Yun Liu* (2018). Dialysis membranes influence perfluorochemical concentrations in patients on hemodialysis. International Journal of Environmental Research and Public Health, 15(11), 2574. (SCIE) *Co-corresponding author
  20. Wen-Sheng Liu, Yen-Ting Lai, Hsiang-Lin Chan, Szu-Yuan Li, ChihChing Lin, Chih-Kuang Liu, Han-Hsing Tsou*, Tsung-Yun Liu* (2018). Associations between perfluorinated chemicals and serum biochemical markers and performance status in uremic patients under hemodialysis. PLOS ONE, 13(7), e0200271. (SCIE) *Co-corresponding author
  21. Tuan Hung Ngo, Han Hsing Tsou, Ya Fang Chen, Yuan Wu Chen, Kai Hsien Chi* (2018). Sources identification of PCDD/Fs in soil and atmospheric deposition in Taiwan. Chemosphere,208, 374-381. (SCIE)
  22. Han-Hsing Tsou, Wen-Chin Hsu, Jong-Ling Fuh, Shih-Pin Chen, Tsung-Yun Liu, Hsiang-Tsui Wang* (2018). Alterations in Acrolein Metabolism Contribute to Alzheimer’s Disease. Journal of Alzheimers Disease, 61(2), 571-580. (SCIE) *First author


研討會論文

  1. Yen-Erh Chen, Han-Hsing Tsou, Development of a Rapid and Highly Sensitive Detection Method for Per- and Polyfluoroalkyl Substances Using the Isotope Dilution Method and Its Application in Evaluating the PFAS Levels in Chronic Kidney Disease Patients Before and After Oral Activated Carbon Capsule Administration. 第10屆亞太質譜年會 (2025, Japan)
  2. Han-Hsing Tsou, The applications of Genomics and Metabolomics in Cancer Research. 2024癌症精準醫學高峰論壇，台灣精準預防醫學學會 (2024，台灣)
  3. Tien-Tien Cheng, Han-Hsing Tsou, Hsiang-Tsui Wang, Wen-Sheng Liu. Removing uremic toxin by oral absorbent with pH-controlled releasing capsule may help improving renal function. 112年度台灣腎臟醫學會會員大會暨學術演講會 (2023，台灣)
  4. 鄒瀚興，由業界視角切入代謝體學於臨床檢測之應用，工研院新興體外診亂醫療器材工作坊第二場 (2023，台灣)
  5. 鄒瀚興，代謝體學應用於中壯年健康評估，金萬林精準醫學研討會 (2023，台灣)
  6. 陳沛穎、王澤文、鄒瀚興，代謝體學應用於個人化精準營養，台灣代謝體學學會會員大會暨學術研討會 (2023，台灣)
  7. 陳冠妤、鄒瀚興，自胺基酸代謝評估維生素B群缺乏，台灣代謝體學學會會員大會暨學術研討會 (2023，台灣)
  8. 鄒瀚興、王澤文、陳沛穎、黃士哲，建立廣效性標的式代謝體學核心實驗室，台灣代謝體學學會會員大會暨學術研討會 (2022，台灣)
  9. 王澤文、陳沛穎、鄒瀚興、黃士哲，開發代謝體學平台用於糖尿病前期的診斷指標，台灣代謝體學學會會員大會暨學術研討會 (2022，台灣)
  10. 黃士哲、陳沛穎、鄒瀚興、王澤文，利用標的式代謝體學檢測全身型健康，台灣代謝體學學會會員大會暨學術研討會 (2022，台灣)
  11. Han-Hsing Tsou, Analysis of target compounds in the environment and food. 金萬林「代謝體學在精準醫療上之應用」研討會 (2022，台灣)
  12. Chia-Tsen Yu, Han-Hsing Tsou*. Metabolomics Study of Amino Acids and Metabolites in Kidney Disease Patients. 18th Taiwan Society for Mass Spectrometry Annual Conference. (2022, Taiwan)
  13. Chun-Yu Chen, Tsung-Yun Liu, Han-Hsing Tsou*. Comparison the carbonyls and tobacco-specific nitrosamines in the mainstream smoke of heated tobacco products and conventional cigarettes by UPLC-QTof. 18th Taiwan Society for Mass Spectrometry Annual Conference. (2022, Taiwan)
  14. 鄒瀚興，精準醫學檢測市場及臨床之應用，第二十九屆吳火獅紀念學術會議 (2021，台灣)
  15. 柯曉彤、鄒瀚興、劉宗榮，The Effect of Betel Quid Chewing on Smoking Induced Oxidative Stress，生物醫學聯合學術年會 (2019，台灣)
  16. Han-Hsing Tsou, Hsiang-Tsui Wang, Tsung-Yun Liu. The effects of betel quid chewing on the metabolism of cigarette containing acrolein in Taiwan. The 8th International congress of Asian Society of Toxicology. (2018, Thailand)
  17. Chih-Hung Hu, Han-Hsing Tsou, Tsung-Yun Liu. Betel quid chewing modulates the cigarette containing acrolein uptake in oral cancer patients. XIV International Congress of Toxicology. (2016, Mexico)
  18. Han-Hsing Tsou, Chih-Hung Hu, Tsung-Yun Liu. The Presence of Protein-Conjugated Acrolein and 3-Hydroxypropyl Mercapturic Acid (3-HPMA) in Patients with Alzheimer’s Disease. XIV International Congress of Toxicology. (2016, Mexico)
  19. Han-Hsing Tsou, Wen-Sheng Liu, Tsung-Yun Liu. Perfluorochemicals in patients under hemodialysis and relations with biochemical markers. The 7th International congress of Asian Society of Toxicology. (2015, Korea)
  20. 鄒瀚興、紀凱獻、劉宗榮，全氟辛酸/全氟辛烷磺酸與慢性腎臟病患者指標之關係，環境分析化學研討會 (2013，台灣)
  21. 鄒瀚興、謝樵漢、陳志銘、胡瓊文、趙木榮，運用連線固相萃取-液相層析串聯質譜儀搭配同位素稀釋法同時分析N-nitrosodimethylamine、N-nitrosomethylethylamine 及 N-nitrosodiethylamine，聯合會員大會暨學術研討會(台灣公共衛生學會、台灣流行病學學會暨台灣事故傷害預防與安全促進學會) (2010，台灣)

 

指導學生論文

  1. 透過代謝體學分析慢性腎臟病患體內全氟/多氟烷基物質、丙烯醛與胺基酸代謝變化之關聯性並探討口服活性碳膠囊介入前後之差異
    國立陽明交通大學／食品安全及健康風險評估研究所／113／碩士／醫藥衛生學門／
    其他醫藥衛生學類/研究生:陳彥而
  2. 血中全氟及多氟烷基物質與丙烯醛在慢性腎臟病患經口服活性碳膠囊前後之效能評估
    國立陽明交通大學／食品安全及健康風險評估研究所／112／碩士／醫藥衛生學門／
    其他醫藥衛生學類/研究生:鄭恬恬
  3. 胺基酸及其代謝物於腎臟病患者之代謝體學研究(搭配統計演算法進行專利申請中)
    國立陽明交通大學／食品安全及健康風險評估研究所／111／碩士／醫藥衛生學門／
    其他醫藥衛生學類/研究生:俞佳岑
  4. 利用超高效能液相層析四極柱串聯飛行時間質譜儀探討加熱菸及傳統紙菸主煙流羰基化合物與菸草特有亞硝胺組成
    國立陽明交通大學／食品安全及健康風險評估研究所／110／碩士／醫藥衛生學門／
    其他醫藥衛生學類/研究生:陳俊宇
  5. 以海鮮替代調查驅動的生魚片微生物菌相的全面調查
    國立陽明交通大學／食品安全及健康風險評估研究所／110／碩士／醫藥衛生學門／
    其他醫藥衛生學類/研究生:何政緯
  6. 探討丙烯醛在人類大腸癌之中的機制
    國立陽明交通大學／食品安全及健康風險評估研究所／109／碩士／醫藥衛生學門／
    其他醫藥衛生學類/研究生:陳芍岑

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