臨床專長為頭痛、失智症、帕金森氏症及神經免疫疾病。

研究興趣主要為頭痛病生理機轉研究，主要針對二大頭痛疾患: “可逆性腦血管收縮症候群(reversible cerebral vasoconstriction syndrome (RCVS))”及”偏頭痛(migraine)”，進行臨床及基礎病生理機轉研究。RCVS是最嚴重最危險的頭痛疾患之一，其主要臨床表現為反覆發作如爆炸般的頭痛(雷擊頭痛)合併血管收縮，並有相當高的機會產生缺血性中風、腦出血或腦後方白質病變等併發症；偏頭痛則是造成最多疾病負擔的神經科疾病，造成的失能人年數排在世界所有疾病第二名，對社會經濟與醫療體系造成巨大的衝擊，但其病生理機轉尚未釐清，治療選擇亦有限。目前實驗室研究主軸為:

1. 雷擊頭痛及可逆性腦血管收縮症候群之臨床、影像及分子生物學研究
2. 偏頭痛病生理機轉之生物標記、動物模式、腦連結體及基因體學研究。

2006 台灣神經學會頭痛學組最佳壁報論文獎

2008 台灣神經學會頭痛學組最佳壁報論文獎

2009 台灣神經學會頭痛學組最佳壁報論文獎

2009 行政院退輔會台北榮民總醫院優良醫師「臨床教學績優醫師獎」

2011 行政院退輔會台北榮民總醫院優良醫師「醫師學術論文獎」

2013 榮陽卓越醫師人才培育計畫獎助

2015 國立陽明大學醫學系優良教師獎

2016 國立陽明大學醫學系優良教師獎

2016 行政院退輔會台北榮民總醫院優良醫師「臨床教學績優醫師獎」

2017 國立陽明大學醫學系優良教師獎 (琉璃獎座)

2018 國立陽明大學醫學系優良教師獎

2018 行政院退輔會台北榮民總醫院優良醫師獎

2018 疼痛學雜誌(Pain)最高引用次數學術論文獎

2018 國立陽明大學醫學系良師益友導師獎

2019 國立陽明大學醫學系優良教師獎

2019 國立陽明大學臨床醫學研究所優良教師獎

2019 國立陽明大學院級教學傑出獎

2019 科技部吳大猷先生紀念獎

2019 行政院退輔會台北榮民總醫院優良醫師「醫師學術論文獎」第二名

(2013-2019, *corresponding author)
 

1. Chen SP, Chung YT, Liu TY, Wang YF, Fuh JL,* Wang SJ.* Oxidative stress and increased formation of vasoconstricting F2-isoprostanes in patients with reversible cerebral vasoconstriction syndrome. Free Radical Biology & Medicine. 2013;61C:243-248.
2. Lin KH, Wang SJ, Fuh JL, Chen SP.* Effectiveness of botulinum toxin A in treatment of refractory erythromelalgia. J Chin Med Assoc. 2013;76:296-8
3. Dou YH, Lai KL, Liao KK, Chen SP.* Abnormal sensory-motor integration in a patient with anti-NMDA-receptor encephalitis. J Neurol. 2012;259:1490-3
4. Lu SR, Fuh JL, Wang SJ,* Juang KD, Chen SP, Liao YC, Wang YF. Incidence and risk factors of chronic daily headache in young adolescents: A school cohort study. Pediatrics 2013; 132:e9-e16.
5. Chang CF, Kuo YL, Chen SP, Wang MC, Liao WH, Tu TY, Shiao AS.* Relationship between idiopathic sudden sensorineural hearing loss and subsequent stroke. Laryngoscope. 2013;123:1011-5.
6. Kao CH, Wang SJ, Tsai CF, Chen SP, Wang YF, Fuh JL*. Psychiatric comorbidities in allodynic migraineurs. Cephalalgia 2014;34:211-8
7. Lin KH, Chen SP, Fuh JL, Wang YF, Wang SJ*. Efficacy, safety, and predictors of response to botulinum toxin type A in refractory chronic migraine: A retrospective study. J Chin Med Assoc. 2014; 77:10-5.
8. Chen SP, Yang AC, Fuh JL, Wang SJ.* Autonomic dysfunction in reversible cerebral vasoconstriction syndromes. The Journal of Headache and Pain 2013, 14:94
9. Dou YH, Fuh JL, Chen SP, Wang SJ.* Reversible Cerebral Vasoconstriction Syndrome after Blood Transfusion. Headache 2014; 54:736-44
10. Chen SP, Wang SJ.* Hyperintense vessels: An early MRI marker of reversible cerebral vasoconstriction syndrome? Cephalalgia 2014; 34: 1038-9
11. Chen SP, Wang YF, Huang PH, Chi CW, Fuh JL,* Wang SJ* Reduced Circulating Endothelial Progenitor Cells in Reversible Cerebral Vasoconstriction Syndrome. The Journal of Headache and Pain 2014;15:82.
12. Chen SP, Fuh JL, Lirng JF, Wang YF, Wang SJ.* Recurrence of Reversible Cerebral Vasoconstriction Syndrome: a Long-Term Follow-up Study. Neurology 2015; 84: 1-7
13. Wang YF, Fuh JL, Lirng JF, Chen SP, Hseu SS, Wu JC, Wang SJ.* Cerebrospinal fluid leakage and headache after lumbar puncture: a prospective non-invasive imaging study. Brain 2015; 138(Pt 6):1492-8
14. Chen YC, Wang YF, Li JY, Chen SP, Lirng JF, Hseu SS, Tung H, Cheng PL, Wang SJ,* Fuh JL.* Treatment and prognosis of subdural hematoma in patients with spontaneous intracranial hypotension. Cephalalgia 2016; 36: 225-31
15. Chen SP,* Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain 2016; 157: 797-805 
16. Chen PR, Lai KL, Fuh JL, Chen SP, Wang PN, Liao KK, Wang SJ.* Efficacy of continuous theta burst stimulation of the primary motor cortex in reducing migraine frequency: a preliminary open-label study. J Chin Med Assoc. 2016; 79:304-8
17. Lee WJ, Wu SL, Li JY, Chen CC, Ling JJ, Peng GS, Lin TK, Wang SJ, Chen RS, Yang YH, Tsai CH, Hsu JL, Liao YC, Chen SP, Fuh JL.* PDD-5S: A Useful Screening Tool for Parkinson’s Disease Dementia. Parkinsonism & Related Disorders 2016; 25: 85-90.
18. Fuh JL, Chung MY, Yao SC, Chen PK, Liao YC, Hsu CL, Wang PJ, Wang YF, Chen SP, Fann CS, Kao LS, Wang SJ.* Susceptible Genes of Restless Legs Syndrome in Migraine. Cephalalgia 2016; 36: 1028-1037
19. Akhter M,* Chen SP. Vascular Emergencies and Shared Decision Making in Patients with Thunderclap Headache. Academic Emergency Medicine. 2016; 23:1194-1195
20. Chen PR, Chen SP.* Posterior Reversible Encephalopathy as the First Manifestation of Bickerstaff's Brainstem Encephalitis. BMC Neurology 2016; 16: 215
21. Wu HY, Hseu SS, Chen SP, Lirng JF, Wang YF, Wang SJ, Fuh JL. Spontaneous intracranial hypotension complicated by malignancy-induced disseminated intravascular coagulation: A case report. Acta Neurologica Taiwanica 2016;25:95-98.
22. Lai KL, Niddam DM, Fuh JL, Chen SP, Wang YF, Chen WT, Wu JC, Wang SJ.* Flunarizine versus topiramate for chronic migraine prophylaxis: a randomized trial. Acta Neurol Scand. 2017; 135:476-483.
23. Oka F, Hoffmann U, Lee JH, Shin HK, Chung D, Yuzawa I, Chen SP, Atalay YB, Nozari A, Park K, Qin T, Ayata C.* Requisite ischemia for spreading depolarizations after subarachnoid haemorrhage. J Cereb Blood Flow Metab 2017; 37:1829-1840
24. Wu JW, Hseu SS, Fuh JL, Lirng JF, Wang YF, Chen WT, Chen SP, Wang SJ*. Factors predicting response to the first epidural blood patch in spontaneous intracranial hypotension. Brain 2017;140:344-52.
25. Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AM., Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-pannexin 1 complex suppresses spreading depolarization and neuroinflammation. Brain 2017; 140:1643-1656
26. Chen SP^¶, Fuh JL^¶, Chung MY^¶, Lin YC, Liao YC, Wang YF, Hsu CL, Yang YC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, Chen YT, Kao LS*, Fann CS*, Wang SJ*. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. Cephalalgia 2018; 38: 466-75 (^¶Equal contribution)
27. Pan YR, Juang KD, Lu SR, Chen SP, Wang YF, Fuh JL*, Wang SJ*. Longitudinal risk factors for suicidal thoughts in depressed and non-depressed young adolescents. Aust N Z J Psychiatry. 2017; 51(9):930-937
28. Cheng CY, Cheng HM, Chen SP, Chung CP, Lin YY, Hu HH, Chen CH, Wang SJ*. White matter hyperintensities in migraine: Clinical significance and central pulsatile hemodynamic correlates. Cephalalgia 2018; 38(7):1225-1236
29. Tsou HH, Hsu WC, Fuh JL, Chen SP, Liu TY, Wang HT. Alterations in acrolein metabolism contribute to Alzheimer’s disease. Journal of Alzheimer’s Disease. 2018;61(2):571-580
30. Cheng CY, Chen SP, Liao YC, Fuh JL, Wang YF, Wang SJ. Elevated circulating endothelial-specific microRNAs in migraine patients: A pilot study. Cephalalgia 2018;38(9):1585-1591
31. Chang YH, Luo CB, Wang SJ, Chen SP*. Cluster headache and middle meningeal artery dural arteriovenous fistulas: A case report. Cephalalgia 2018; 38(11): 1792–1796
32. Yalcin N^¶, Chen SP^¶, Yu ES, Liu TT, Yen JC, Atalay YB, Qin T, Celik F, van den Maagdenberg AM, Moskowitz MA, Ayata C, Eikermann-Haerter K*. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab 2019 Apr;39(4):740-750. (^¶Equal contribution)
33. Chen SP*, Chou KH,^¶ Fuh JL,^¶ Huang YH, Huang CC, Lirng JF, Wang YF, Lin CP, Wang SJ.* Dynamic Changes in White Matter Hyperintensities in Reversible Cerebral Vasoconstriction Syndrome. JAMA Neurology 2018;75(9):1106-1113. doi:10.1001/jamaneurol.2018.1321 (*Equal contribution; ^¶Equal contribution)
34. Chen CY, Chen SP*, Fuh JL, Lirng JF, Chang FC, Wang YF, Wang SJ. Vascular Wall Imaging in Reversible Cerebral Vasoconstriction Syndrome - A 3-T Contrast-enhanced MRI study. The Journal of Headache and Pain 2018; 19: 74.
35. Wu JW, Wang YF, Fuh JL, Lirng JF, Chen SP, Hseu SS, Wang SJ. Correlations among brain and spinal MRI findings in spontaneous intracranial hypotension. Cephalalgia 2019: 38(14): 1998-2005.
36. Shih YC, Chen SP,* Fuh JL, Wang YF, Wang SJ. Influence of climate on the incidence of RCVS – a retrospective study from Taiwan. Headache 2019; 59(4): 567-575.
37. Kuan AS, Chen SP, Wang YF, Fuh JL, Cheng CY, Peng KP, Wang SJ. Risk factors and psychological impact of syncope in migraine patients. Cephalalgia 2019 in press

Review Articles

1. Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes- an under-recognised clinical emergency. Ther Adv Neurol Disord 2010; 3: 161-71.
2. Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes: Current and future perspectives. Expert Rev Neurother 2011; 11:1265-76.
3. Chen SP, Ayata C.* Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2016; 20(7):44.
4. Chen SP, Tolner EA,* Eikermann-Haerter K.* Animal models of monogenic migraine. Cephalalgia 2016; 36: 704-21
5. Chen SP, Ayata C.* Novel Therapeutic Targets against Spreading Depression. Headache 2017;57:1340-1358.
6. Chou TM, Chen SP*. Animal Models of Chronic Migraine. Current Pain and Headache Reports. 2018: 19;22(6):44.
7. Harriott AM, Takizawa T, Chung DY, Chen SP*. Spreading Depression as a Model of Migraine. The Journal of Headache and Pain 2019;20(1):45.
8. Tolner E. *, Chen SP, Eikermann-Haerter K. Current understanding of cortical structure and function in headache. Cephalalgia 2019 in press.

Textbook Chapters

1. Chen SP, Pascual J, Wang SJ. Chapter 25: Exertional and Sex Headache– In Michel Ferrari, Joost Haan, Andrew Charles, David Dodick, and Fumihiko Sakai (eds.), Oxford Textbook of Headache Syndromes (Oxford Textbooks in Clinical Neurology), Oxford Press, 2016
2. Chen SP, Wang SJ. Chapter 15. Reversible cerebral vasoconstriction syndrome. International Neurology. 2^nd edition. 2016; DOI: 10.1002/9781118777329.ch15 (Publisher: Wiley-Blackwell)
3. Chen SP, Theriot J, Brennan KC, Ayata C. Chapter 19. Animal model of migraine aura. Neurobiologic Basis of Migraine. 1^st ed. Edited by Turgay Dalkara and Michael A. Moskowitz. JohnWiley & Sons, Inc. 2017
4. Chen SP, Wang SJ. Headaches due to vascular disorders. Modern Day Management of Headache- Questions and Answers. Edited by K Ravishankar, Randolph W Evans and Shuu-Jiun Wang. Jaypee- The Health Science Publisher, 2017