臺北榮民總醫院醫學研究部

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神經血管研究室

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主持人：陳世彬
Tel : +886-2-28712121 Ext. 8143 E-mail: spchen2@vghtpe.gov.tw
現職:
2017-	臺北榮民總醫院醫學研究部轉譯研究科主治醫師
2017-	臺北榮民總醫院醫學科技大樓管理中心主任
2016-	國立陽明大學臨床醫學研究所專任副教授
2018-	國立陽明大學神經科學研究所合聘副教授
2015-	國立陽明大學醫學系神經學科兼任副教授
2016-	跨領域神經科學-國際研究生博士班學程 (TIGP-INS)兼任副教授

學經歷:
1995-2002	國立陽明大學醫學士
2006-2010	國立陽明大學臨床醫學研究所博士
2008-2017	臺北榮民總醫院神經內科主治醫師
2012-2014	哈佛醫學院麻州總醫院神經血管研究室博士後研究員

《研究興趣》
研究興趣主要為頭痛病生理機轉研究，包括 1.雷擊頭痛及可逆性腦血管收縮症候群之臨床、影像及分子生物學研究 2.偏頭痛病生理機轉之生物標記、動物模式、腦連結體及基因體學研究。
《近期研究著作》
10 Selected publications Chen SP, Fuh JL, Lirng JF, Chang FC, Wang SJ.* Recurrent primary thunderclap headache and benign CNS angiopathy: spectra of the same disorder? *Neurology. 2006;67:2164-9. Chen SP, Fuh JL, Chang FC, Lirng JF, Shia BC, Wang SJ. A transcranial color doppler study for reversible cerebral vasoconstriction syndromes. *Ann Neurol* 2008; 63: 751-7. Chen SP, Fuh JL, Lu SR, Wang SJ.* Exertional headache - a survey of 1,963 adolescents. Cephalalgia 2009; 29: 401-7 Chen SP, Fuh JL, Wang SJ,* Chang FC, Lirng JF, Fang YC, Shia BC, Wu JC. Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. *Ann Neurol* 2010; 67: 648-56. Chen SP, Fuh JL, Lirng JF, Wang SJ.Hyperintense vessels on FLAIR imaging in reversible cerebral vasoconstriction syndromes. Cephalalgia* 2012; 32:271-8 Chen SP, Chung YT, Liu TY, Wang YF, Fuh JL,* Wang SJ.* Oxidative stress and increased formation of vasoconstricting F2-isoprostanes in patients with reversible cerebral vasoconstriction syndrome. *Free Radical Biology & Medicine. 2013;61C:243-248. Chen SP, Fuh JL, Lirng JF, Wang YF, Wang SJ. Recurrence of Reversible Cerebral Vasoconstriction Syndrome: a Long-Term Follow-up Study. *Neurology* 2015; 84: 1-7 Chen SP,* Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. *Pain* 2016; 157: 797-805 Chen SP, Fuh JL, Chung MY, Lin YC, Liao YC, Wang YF, Hsu CL, Yang YC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, Chen YT, Kao LS, Fann CS, Wang SJ. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. Cephalalgia 2017 in press Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AM., Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-pannexin 1 complex suppresses spreading depolarization and neuroinflammation. Brain* 2017; 140:1643-1656 Review Articles Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes- an under-recognised clinical emergency. Ther Adv Neurol Disord 2010; 3: 161-71. Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes: Current and future perspectives. Expert Rev Neurother 2011; 11:1265-76. Chen SP, Ayata C.* Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2016; 20(7):44. Chen SP, Tolner EA,* Eikermann-Haerter K.* Animal models of monogenic migraine. Cephalalgia 2016; 36: 704-21 Chen SP, Ayata C.* Novel Therapeutic Targets against Spreading Depression. Headache 2017;57:1340-1358. Textbook Chapters Chen SP, Pascual J, Wang SJ. Chapter 25: Exertional and Sex Headache– In Michel Ferrari, Joost Haan, Andrew Charles, David Dodick, and Fumihiko Sakai (eds.), Oxford Textbook of Headache Syndromes (Oxford Textbooks in Clinical Neurology), Oxford Press, 2016 Chen SP, Wang SJ. Chapter 15. Reversible cerebral vasoconstriction syndrome. International Neurology. 2^nd edition. 2016; DOI: 10.1002/9781118777329.ch15 (Publisher: Wiley-Blackwell) Chen SP, Theriot J, Brennan KC, Ayata C. Chapter 19. Animal model of migraine aura. Neurobiologic Basis of Migraine. 1^st ed. Edited by Turgay Dalkara and Michael A. Moskowitz. JohnWiley & Sons, Inc. 2017 Chen SP, Wang SJ. Headaches due to vascular disorders. Modern Day Management of Headache- Questions and Answers. Edited by K Ravishankar, Randolph W Evans and Shuu-Jiun Wang. Jaypee- The Health Science Publisher, 2017

《研究興趣》

研究興趣主要為頭痛病生理機轉研究，包括
1.雷擊頭痛及可逆性腦血管收縮症候群之臨床、影像及分子生物學研究
2.偏頭痛病生理機轉之生物標記、動物模式、腦連結體及基因體學研究。

《近期研究著作》

10 Selected publications

Chen SP, Fuh JL, Lirng JF, Chang FC, Wang SJ.* Recurrent primary thunderclap headache and benign CNS angiopathy: spectra of the same disorder? Neurology. 2006;67:2164-9.
Chen SP, Fuh JL, Chang FC, Lirng JF, Shia BC, Wang SJ.* A transcranial color doppler study for reversible cerebral vasoconstriction syndromes. Ann Neurol 2008; 63: 751-7.
Chen SP, Fuh JL, Lu SR, Wang SJ.* Exertional headache - a survey of 1,963 adolescents. Cephalalgia 2009; 29: 401-7
Chen SP, Fuh JL, Wang SJ,* Chang FC, Lirng JF, Fang YC, Shia BC, Wu JC. Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. Ann Neurol 2010; 67: 648-56.
Chen SP, Fuh JL, Lirng JF, Wang SJ.*Hyperintense vessels on FLAIR imaging in reversible cerebral vasoconstriction syndromes. Cephalalgia 2012; 32:271-8
Chen SP, Chung YT, Liu TY, Wang YF, Fuh JL,* Wang SJ.* Oxidative stress and increased formation of vasoconstricting F2-isoprostanes in patients with reversible cerebral vasoconstriction syndrome. Free Radical Biology & Medicine. 2013;61C:243-248.
Chen SP, Fuh JL, Lirng JF, Wang YF, Wang SJ.* Recurrence of Reversible Cerebral Vasoconstriction Syndrome: a Long-Term Follow-up Study. Neurology 2015; 84: 1-7
Chen SP,* Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain 2016; 157: 797-805
Chen SP, Fuh JL, Chung MY, Lin YC, Liao YC, Wang YF, Hsu CL, Yang YC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, Chen YT, Kao LS*, Fann CS*, Wang SJ*. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. Cephalalgia 2017 in press
Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AM., Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-pannexin 1 complex suppresses spreading depolarization and neuroinflammation. Brain 2017; 140:1643-1656

Review Articles

Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes- an under-recognised clinical emergency. Ther Adv Neurol Disord 2010; 3: 161-71.
Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes: Current and future perspectives. Expert Rev Neurother 2011; 11:1265-76.
Chen SP, Ayata C.* Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2016; 20(7):44.
Chen SP, Tolner EA,* Eikermann-Haerter K.* Animal models of monogenic migraine. Cephalalgia 2016; 36: 704-21
Chen SP, Ayata C.* Novel Therapeutic Targets against Spreading Depression. Headache 2017;57:1340-1358.

Textbook Chapters

Chen SP, Pascual J, Wang SJ. Chapter 25: Exertional and Sex Headache– In Michel Ferrari, Joost Haan, Andrew Charles, David Dodick, and Fumihiko Sakai (eds.), Oxford Textbook of Headache Syndromes (Oxford Textbooks in Clinical Neurology), Oxford Press, 2016
Chen SP, Wang SJ. Chapter 15. Reversible cerebral vasoconstriction syndrome. International Neurology. 2^nd edition. 2016; DOI: 10.1002/9781118777329.ch15 (Publisher: Wiley-Blackwell)
Chen SP, Theriot J, Brennan KC, Ayata C. Chapter 19. Animal model of migraine aura. Neurobiologic Basis of Migraine. 1^st ed. Edited by Turgay Dalkara and Michael A. Moskowitz. JohnWiley & Sons, Inc. 2017
Chen SP, Wang SJ. Headaches due to vascular disorders. Modern Day Management of Headache- Questions and Answers. Edited by K Ravishankar, Randolph W Evans and Shuu-Jiun Wang. Jaypee- The Health Science Publisher, 2017

最後更新： 2018/01/02 11:18:18