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精神疾病腦造影研究室

TEL: +886-2-28712121 Ext.7401
E-mail:pctu@vghtpe.gov.tw
主持人:杜培基
    醫學研究部研究員杜培基
學歷:  
1988-1995 陽明大學醫學院醫學士
2001-2004 中正大學文學院 哲學碩士
2005-2011 陽明大學生命科學院認知神經科學博士
經歷:  
1996-2000 臺北榮民總醫院精神部住院醫師及總醫師
2000-2004 灣橋榮民醫院精神科主治醫師
2004-2006 臺北市立關渡醫院精神科主治醫師
2007-2009 波士頓麻省總醫院精神影像部博士後研究員
2010-2013 臺北榮民總醫院教學研究部主治醫師
現職:  
2013 ~ 迄今 臺北榮民總醫院醫學研究部主治醫師
《獎項 》
2006/08-2007/07  獎學金, 國家衛生研究院, 醫師博士(MD. P.H.D) 學位課程
2007/11-2008/10  獎學金, 先進多模式神經影像訓練課程( Advanced Multimodal Neuroimaging Training Programs), Martinos Center for Biomedical Imaging, 波士頓
2012  台灣精神醫學會, 保羅楊森精神分裂研究論文獎
2016  台灣精神醫學會, 保羅楊森精神分裂研究論文獎
2019  臺灣生物精神醫學暨神經精神藥理學學會, 保羅楊森研究論文獎
2020  臺北榮民總醫院, 學術論文獎佳作
《專業執照及職位 》
1999/10  台灣精神醫學會會員
2004/10  台灣老人精神醫學會會員
2010/10  台灣生物精神醫學暨神經藥理學會秘書長
《研究領域》

1. 功能性核磁共振造影 (functional MRI, fMRI)
2. 功能連結核磁共振造影  (functional connectivity MRI, fcMRI)
3. 精神疾病腦造影 ( Psychiatric Neuroimaging)
4. 自我與意識的神經基礎 ( Neural substrates for human self and conscious awareness) 

《執行中計畫》

1.利用個體間同步性分析功能性核磁共振訊號研究雙極性疾患患者社會認知缺損的神經基礎(第二年) (臺北榮民總醫院V111C-019, 2022/01/01-2022/12/31, 主持人)
2.以人工智慧判讀顳顎關節核磁共振影像 (臺北榮民總醫院V111E-002-4, 2022/01/01-2022/12/31, 主持人)
3.思覺失調異常患者的兩側大腦功能連結缺損及其對主觀視覺意識經驗的影響 (國科會 111-2314-B-075 -017, 2022/08/01~2023/07/31,主持人)

《近期研究著作》

論文及著作:

1.Tu PC, Chang WC, Chen MH, Hsu JW, Lin WC, Li CT, Su TP, Bai YM. Identifying common and distinct subcortical volumetric abnormalities in 3 major psychiatric disorders: a single-site analysis of 640 participants. J Psychiatry Neurosci. 2022 Jun 21;47(3)

2.Lee LH, Chen CH, Chang WC, Lee PL, Shyu KK, Chen MH, Hsu Ju-Wei, Bai YM, Su TP, & Tu PC*. Evaluating the Performance of Machine Learning Models for Automatic Diagnosis of Patients with Schizophrenia Based on a Single Site Dataset of 440 Participants. Eur Psychiatry. 2021 Dec 23;65(1)

3.Tu, P. C., Chen, M. H., Chang, W. C., Kao, Z. K., Hsu, J. W., Lin, W. C., Li, C. T., Su, T. P. & Bai, Y. M. Identification of common neural substrates with connectomic abnormalities in four major psychiatric disorders: A connectome-wide association study. Eur Psychiatry.  2020 Dec 3;64(1)

4.Chen MH, Lin WC, Tu PC*, Li CT, Bai YM, Tsai SJ, Su TP. Antidepressant and antisuicidal effects of ketamine on the functional connectivity of prefrontal cortex-related circuits in treatment-resistant depression: A double-blind, placebo-controlled, randomized, longitudinal resting fMRI studyJ Affect Disord. 2019 Dec 1;259:15-20.

5.PC Tu, TP Su, WC Lin, WC Chang, YM Bai, CT Li, FH Lin. Reduced synchronized brain activity in schizophrenia during viewing of comedy movies. Scientific reports. 2019; 9(1):12738.

6.Tu, P. C., Bai, Y. M., Li, C. T., Chen, M. H., Lin, W. C., Chang, W. C., & Su, T. P..Identification of Common Thalamocortical Dysconnectivity in Four Major Psychiatric Disorders. Schizophrenia bulletin. 2019;45(5):1143-1151.

7.Chen MH, Chang WC, Bai YM, Huang KL, Tu PC*,, Su TP, Li CT, Lin WC, Tsai SJ, Hsu JW. Cortico-thalamic dysconnection in early-stage schizophrenia: a functional connectivity magnetic resonance imaging study. Eur Arch Psychiatry Clin Neurosci. 2019

8.Chen MH, Chang WC, Hsu JW, Huang KL, Tu PC*, Su TP, Li CT, Lin WC, Bai YM*.Correlation of proinflammatory cytokines levels and reduced gray matter volumes between patients with bipolar disorder and unipolar depression. Journal of affective disorders. 2018; 245, 8-15.

9.Tu,P. C., Kuan, Y.H., Li, C.T., Su, T. P. Structural Correlates of Trait Impulsivity in Patients with Bipolar Disorder and Healthy Controls — A Surface-Based Morphometry Study. Psychological medicine. 2017; 47(7):1292-1299.

10.Tu PC, Li CT, Lin WC, Chen MH, Su TP, Bai YM. Structural and functional correlates of serum soluble IL-6 receptor level in patients with bipolar disorder. Journal of affective disorders. 2017; 219:172-7.

11.Tu PC, Kuan YH, Li CT, Su TP. Structural correlates of creative thinking in patients with bipolar disorder and healthy controls-a voxel-based morphometry study. Journal of affective disorders. 2017; 215:218-24.

12.Tu, P. C., Hsu, J. W., Lan, C. C., Liu, C. C., Su, T. P., & Chen, Y. S.. Structural and functional correlates of a quantitative autistic trait measured using the social responsive scale in neurotypical male adolescents. Autism research. 2016; 9(5):570-8.

13.Tu P-C, Lee Y-C, Chen Y-S, Hsu J-W, Li C-T, Su T-P. Network-specific cortico-thalamic dysconnection in schizophrenia revealed by intrinsic functional connectivity analyses. Schizophrenia research. 2015; 166(1–3):137-43.

14.Tu PC, Su TP, Huang CC, Yang AC, Yeh HL, Hong CJ, et al. Interleukin-1 beta C-511T polymorphism modulates functional connectivity of anterior midcingulate cortex in non-demented elderly Han males. Brain structure & function. 2014; 219(1):61-9.

15.Tu PC, Lee YC, Chen YS, Li CT, Su TP. Schizophrenia and the brain's control network: aberrant within- and between-network connectivity of the frontoparietal network in schizophrenia. Schizophrenia research. 2013; 147(2-3):339-4

16.Chen YL, Tu PC, Lee YC, Chen YS, Li CT, Su TP. Resting-state fMRI mapping of cerebellar functional dysconnections involving multiple large-scale networks in patients with schizophrenia. Schizophrenia research. 2013; 149(1-3):26-34.

17.Tu PC, Hsieh JC, Li CT, Bai YM, Su TP. Cortico-striatal disconnection within the cingulo-opercular network in schizophrenia revealed by intrinsic functional connectivity analysis: a resting fMRI study. NeuroImage. 2012; 59(1):238-47.

18.Tu PC, Chen LF, Hsieh JC, Bai YM, Li CT, Su TP. Regional cortical thinning in patients with major depressive disorder: a surface-based morphometry study. Psychiatry research. 2012; 202(3):206-13.

19.Cheng HL, Lin CJ, Soong BW, Wang PN, Chang FC, Wu YT, Chou KH, Lin CP, Tu PC*, Lee IH*. Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis. Stroke. 2012; 43(10):2567-73.

20.Peichi Tu, Randy L. Buckner, Lilla Zollei, Kara A. Dyckman, Donald C. Goff and Dara S. Manoach. Reduced functional connectivity in a right-hemisphere network for volitional ocular motor control in schizophrenia. Brain. 2010; 133:625-37.

21.Kong J1, Tu PC, Zyloney C, Su TP. Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study. Behavior brain research. 2010;211(2):215-9.

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