臺北榮民總醫院醫學研究部

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醣生物學研究室

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主持人：梁毓津
TEL: +886-2-28712121 Ext.7778 E-mail: yjliang@vghtpe.gov.tw
2002 ~2008	國防醫學大學生命科學所博士
2008 ~ 2011	中央研究院基因體中心幹細胞中心博士後研究員
2011 ~ 2013	美國華盛頓大學博士後研究員
2013 ~ 2017	長庚紀念醫院醫學研究部助理研究員
2017 ~迄今	長庚科技大學兼任助理教授
2017 ~迄今	臺北榮民總醫院醫學研究部高級助理研究員

《研究興趣》
(1)醣鞘脂及醣蛋白對幹細胞分化的影響 (2)醣鞘脂及醣蛋白在癌症診斷及治療上的應用 (3)醣組學研究
《未來方向》
(1)癌症糖鞘脂與腫瘤微環境的關係 (2)醣鞘脂及醣蛋白做為診斷標誌物之轉譯應用
《近期研究著作》
1. Liang YJ, Sun CP, Hsu YC, Chen YW, Wang IA, Su CW, Tao MH, Wu JC. Statin inhibits large hepatitis delta antigen-Smad3 -twist-mediated epithelial-to-mesenchymal transition and hepatitis D virus secretion. J Biomed Sci. 2020 May 21;27(1):65. (FIRST AUTHOR, IF 5.203, Rank: 20/136, Q1, MEDICINE, RESEARCH & EXPERIMENTAL) 2. Wang SY, Chen CL, Hu YC, Chi Y, Huang YH, Su CW, Jeng WJ, Liang YJ, Wu JC. High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger Patients. Cancers (Basel). 2019 Oct 13;11(10):1549. (CO-AUTHOR, IF 6.162, Rank 31/280, Q1, ONCOLOGY) 3. Cheng KC, Lin RJ, Cheng JY, Wang SH, Yu JC, Wu JC, Liang YJ, Hsu HM, Yu J, Yu AL. FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. EBioMedicine. 2019 Jul;45:25-38. (CO-AUTHOR, IF 6.680, Rank 11/136, Q1, MEDICINE, RESEARCH & EXPERIMENTAL) 4. Chen CL, Tsai YS, Huang YH, Liang YJ, Sun YY, Su CW, Chau GY, Yeh YC, Chang YS, Hu JT, Wu JC. Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial-Mesenchymal Transition Regulators and Stemness Genes. Hepatol Commun. 2018 Sep 28;2(11):1392-1407. 5. Liang, Y.J., Wang, C.Y., Wang I.A., Chen, Y.W., Li, T.Z., Lin, C.Y., Ho, M.Y., Chou, T.L., Yu, J., Oncotarget. 2017 Jul 18. Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. Oncotarget 8(29):47454-47473. (FIRST AUTHOR and CORRESPONDING AUTHOR, IF=5.415; R/C= 36/213; JIF Percentile= 83.333%, ONCOLOGY) 6. Wu YC, Wang WT, Huang LJ, Liang YJ, Liu YS, Cheng RY, Steve Chen-Lung Lin Steve CL, Kuo YR, Hou MF, Lai CS, and Yu, J., Differential effects of conditioned medium from adipocyte-derived stromal cells on non-cancerous and breast cancer cells. International Journal of Molecular Sciences, 2018 under revise. (CO-AUTHOR) 7. Cheng KC, Lin YC, Lai Alan CY, Liang YJ, Chen YJ and Yu Alice L. FAM129B regulates cell proliferation and activates NF-κB and Nrf2 by inactivating KEAP1 in cancer cells. Cancer Research, 2018 in submission. (CO-AUTHOR) 8. Wu YC, Wang WT, Huang LJ, Liang YJ, Liu YS, Cheng RY, Steve Chen-Lung Lin Steve CL, Kuo YR, Hou MF, Lai CS, and Yu, J., YULINK is required for insulin-stimulated adipogenesis and glucose uptake in adipocytes by interacting with lipid rafts. Stem Cells, 2018 in submission. (CO-AUTHOR) 9. Liang, Y.J., Ding, Y., Levery, S.B., Lobaton, M., Handa, K., Hakomori, S., 2013. Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells. Proc Natl Acad Sci U S A 110 (13), 4968-4973. (FIRST AUTHOR, IF=9.809; R/C= 4/55; JIF Percentile= 93.636%, MULTIDISCIPLINARY SCIENCES) Book chapter 1. Yuh-Jin Liang, Kay-Hooi Khoo, and John Yu. Roles of Glycosphingolipid Structures in Human Embryonic Stem Cells and Breast Cancer Stem Cells. The Molecular Immunology of Complex of Carbohydrates-4 (MMIC4): Cancer and Stem Cell Biology. Editor Albert M. M. Wu , Springer -Verlag London Ltd, UK. 2.梁毓津、洪榮堂、陳鈴津、游正博。醣鞘脂於胚胎幹細胞分化過程之變化與癌免疫治療之應用. (Book Chapter) 2018年09月; 再生醫學：臨床與產業應用（ISBN：978-986-05-6694-9,p 59-83）。台灣,中華民國：科技部再生醫學科技發展計畫辦公室出版。 Selected Conference Papers 1. Jaw-Ching Wu, Yu-Chen Hsu, Yuh-Jin Liang, Chien-Wei Su: Statin Inhibits HDV assembly, secretion and Large Hepatitis Delta Antigen-Smad3 -Twist-Mediated Epithelial-Mesenchymal Transition, oral presented at The International Liver Congress^TM 2018, Paris, France, APRIL 11-15, 2018. 2. Chih-Li Chen, Yuh-Jin Liang, Chien-Wei Su, Jaw-Ching Wu “LEF1 reciprocally regulates EMT regulators and stemness gene Oct4 via Wnt dependent and independent pathways and plays a pivotal role in postoperative HCC recurrence”, poster presented at 2018 American Association for the Study of Liver Diseases AASLD, San Francisco, November 9-13, 2018. (2018 Presidential Poster of distinction) 3. Yuh-Jin Liang, Rui-Dung Teng, Cheng-Pu Sun, Chien-Wei Su, Yi Chi, Ming-Hua Tao, Jaw-Ching Wu: “The pre-S2 deletion HBV mutants are responsible for the intracellular accumulation of the HBs proteins, ER stress and mitochondria dysfunction”, oral presented at The International Liver Congress™ 2019, Vienna, Austria, April 10-14, 2019. 4. Yuh-Jin Liang, Jaw-Ching Wu: “The pre-S2 deletion HBV mutants are responsible for the intracellular accumulation of the HBs protein, ER stress and mitochondria dysfunction”, oral presented at 2019 Annual VTA Joint Project Symposium, Academia Sinica, Taipei, Jun 22, 2019.

最後更新： 2020/09/18 10:26:35