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醣生物學研究室

TEL: +886-2-28712121 Ext.27778
E-mail: [email protected]
 主持人:梁毓津
2002 ~2008  國防醫學大學生命科學所博士
2008 ~ 2011中央研究院基因體中心幹細胞中心博士後研究員
2011 ~ 2013美國華盛頓大學博士後研究員
2013 ~ 2017長庚紀念醫院醫學研究部助理研究員
2017 ~迄今長庚科技大學兼任助理教授
2017 ~迄今臺北榮民總醫院醫學研究部高級助理研究員
2022~迄今臺北榮民總醫院醫學研究部 副研究員
2021~迄今國立陽明交通大學臨床醫學研究所兼任助理教授
梁毓津博士
《研究興趣》
(1) 癌症糖鞘脂與腫瘤微環境的關係
(2) 醣鞘脂及醣蛋白在癌症診斷及治療上的應用
(3) 以肝癌特異性表達之醣鞘脂開發肝癌生物標誌並研究其應用於癌症診斷或免疫
(4) 肝炎病毒與肝癌研究
《近期研究著作》

SELECTED PUBLICATIONS

1. Wang SY, Huang YH, Liang YJ, Wu JC. Gene Co-Expression Network Analysis Identifies Hubs in Hepatitis B Virus-Associated Hepatocellular Carcinoma. J Chin Med Assoc. 2022 Oct 1;85(10):972-980.

2. Chang YS, Su CW, Chen SC, Chen YY, Liang YJ, Wu JC*. Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance. Cells. 2022 Feb 11;11(4):634.

3. Liang YJ*. Glycosphingolipids in human embryonic stem cells and breast cancer stem cells, and potential cancer therapy strategies based on their structures and functions. Glycoconj J. 2022 Apr;39(2):177-195.

4. Liang, YJ, Teng W, Chen CL, Sun CP, Teng RD, Huang YH, Liang KH, Chen YW, Lin CC, Su CW, Tao MH, Wu JC. Clinical implications on HBV preS/S mutations and the effects of preS2 deletion on mitochondria, liver fibrosis, and cancer development. 2021 Aug;74(2):641-655.

5. Liang, YJ, Cheng-Pu Sun, Chien-Wen Pu, Yu-Chen Hsu, I-An Wang, Yi-Wen Chen, Chien-Wei Su, Mi-Hua Tao, Jaw-Ching Wu*. Statin inhibits large hepatitis delta antigen-Smad3 -twist-mediated epithelial-to-mesenchymal transition and hepatitis D virus secretion. J Biomed Sci. 2020 May 21;27(1):65.

6. Shen-Yung Wang, Chih-Li Chen, Yu-Chen Hu, Yi Chi, Yen-Hua Huang, Chien-Wei Su, Wen-Juei Jeng, Liang, YJ, Jaw-Ching Wu*. High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger Patients. Cancers (Basel). 2019 Oct 13;11(10):1549.

7. Cheng KC, Lin RJ, Cheng JY, Wang SH, Yu JC, Wu JC, Liang YJ, Hsu HM, Yu J, Yu AL. FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. EBioMedicine. 2019 Jul;45:25-38. 

8. Chen CL, Tsai YS, Huang YH, Liang YJ, Sun YY, Su CW, Chau GY, Yeh YC, Chang YS, Hu JT, Wu JC. Lymphoid Enhancer Factor 1 Contributes to Hepatocellular Carcinoma Progression Through Transcriptional Regulation of Epithelial-Mesenchymal Transition Regulators and Stemness Genes. Hepatol Commun. 2018 Sep 28;2(11):1392-1407.

9. Liang, YJ,*, Chen-Yu Wang, I-An Wang, Yi-Wen Chen, Li-Tzu Li, Chuang-Yu Lin, Ming-Yi Ho, Tsung-Lung Chou, Ya-Hui Wang, Shih-Pin Chiou, Yu-Ju Lin, John Yu*. Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. 2017 Jul 18;8(29):47454-47473.

10. Liang, YJ, Steven B Levery, Marlin Lobaton, Kazuko Handa, Sen-itiroh Hakomori*. Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells. Proc Natl Acad Sci U S A. 2013;110(13):4968-73.

11. Liang, YJ, Bei-Chia Yang, Jin-Mei Chen, Yu-Hsing Lin, Chia-Lin Huang, Yuan-Yuan Cheng, Chi-Yen Hsu, Kay-Hooi Khoo, Chia-Ning Shen, John Yu*. Changes in glycosphingolipid composition during differentiation of human embryonic stem cells to ectodermal or endodermal lineages. Stem Cells. 2011;29(12):1995-2004.

12. Liang, YJ, Huan-Hsien Kuo, Chi-Hung Lin, Yen-Ying Chen, Bei-Chia Yang, Yuan-Yuan Cheng, Alice L Yu, Kay-Hooi Khoo, John Yu*. Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation. Proc Natl Acad Sci U S A. 2010;107(52):22564-9.

13. Chang, H.S., Lin, C.H., Yang, C.H., Liang, Y.J., Yu, W.C., 2010. The human papillomavirus-16 (HPV-16) oncoprotein E7 conjugates with and mediates the role of the transforming growth factor-beta inducible early gene 1 (TIEG1) in apoptosis. The international journal of biochemistry & cell biology 42, 1831-1839. 12 citations.

14. Liang, Y.J., Chang, H.S., Wang, C.Y., Yu, W.C., 2008. DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues. The international journal of biochemistry & cell biology 40 (11), 2431-2441.

 

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