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神經藥理研究室

TEL: +886-2-28712121 Ext.2688
E-mail: myalin@vghtpe.gov.tw
主持人:林滿玉
1978 ~1982 國立臺灣大學藥學系學士
1982 ~ 1984 國立臺灣臺大學藥理學研究所碩士
1989 ~ 1992 美國科羅拉多州州立大學博士
《現職》  
2022/08 ~ 迄今 國立陽明交通大學藥物科學院院長
2019/12 ~ 迄今 台灣女科技人學會理事長
2016/08 ~ 迄今 國立陽明交通大學藥學系專任教授
2005/08 ~ 迄今 臺北榮民總醫院醫學研究部合聘研究員
2005/08 ~ 迄今 國立陽明交通大學食安所、生藥所、藥理所及生理所合聘教授
《經歷》  
2016/08 ~ 2022/07 國立陽明大學藥學系主任
2015/08 ~ 2016/07 國立陽明大學藥學系籌備處主任
2008/08 ~ 2014 國立陽明大學藥理學研究所所長
2005/08 ~ 2008/07 國立陽明大學生理學研究所專任教授
2005/04 ~ 2005/08 臺北榮民總醫院醫學研究部專任研究員
1998 ~ 2005/08 國立陽明大學生理學研究所兼任副教授
1996 ~ 2005/04 臺北榮民總醫院醫學研究部專任副研究員
1993/10 ~ 1996/10 中央研究院生物醫學科學研究所博士後研究員
1992/08 ~ 1993/09 美國國家衛生研究院客座博士後研究員
《研究方向》

(1)蛋白質堆積、發炎複合體和外泌體在神經退化性疾病的角色
(2)新藥研發之轉譯應用

得獎紀錄

2022年台北榮總 學術論文獎-醫事人員組-第一名

2019年台北榮總 學術論文獎-醫事人員組-第二名

2013年台北榮總 學術論文獎-醫事人員組-第二名

《代表著作 》

1. Yu-Li Lo, Tse-Yuan Wang, Chun-Jung Chen, Yih-Hsin Chang and Anya Maan-Yuh Lin*. Two-in-One Nanoparticle Formulation to Deliver a Tyrosine Kinase Inhibitor and microRNA for Targeting Metabolic Reprogramming and Mitochondrial Dysfunction in Gastric Cancer. Pharmaceutics (2022) Aug 23:14: 1759.doi:10.3390/pharmaceutics14091759(通訊作者)

2. Yu-Show Fu , Chang-Ching Yeh, Pei-Ming Chu , Wen-Hsing Chang , Anya Maan-Yuh Lin , Yung-Yang Lin. Xenograft of Human Umbilical Mesenchymal Stem Cells Promotes Recovery from Chronic Ischemic Stroke in Rats. International Journal of Molecular Science (2022) 2022 Mar 15;23(6):3149. doi: 10.3390/ijms23063149 (通訊作者)

3. Hui-Ju Huang, Hsiang-Tsui Wang, Ting-Yu Yeh, Bo-Wei Lin, Young-Ji Shiao, Yu-Li Lo, Anya Maan-Yuh Lin*. Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity. Scientific Report 2021 Jun 14;11(1):12497. (通訊作者)

4. Yu-Li Lo; Hua-Ching Lin; Shu-Ting Hong; Chih-Hsien Chang; Chen-Shen Wang; Anya Maan-Yuh Lin*. Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood–brain barrier model. Cancer Nanotechnology.12:13. (2021) (通訊作者)

5. Chia-Chi Hsu, Albert Ying-Po Yang, Jui-Yi Chen, Hsin-Hui Tsai, Shu-Heng Lin, Pei-Chen Tai, Ming-Hung Huang, Wei-Hsun Hsu, Anya Maan-Yuh Lin*, James Chih-Hsin Yang. Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells. Cancers (Basel) 2021 Jan 13;13(2):272. (通訊作者)

6. Wen-Chien Ho, Chia-Chi Hsu, Hui-Ju Huang, Hsiang-Tsui Wang , Anya Maan-Yuh Lin* Anti-inflammatory Effect of AZD6244 on Acrolein-Induced Neuroinflammation. Mol Neurobiol. 2020 Jan;57(1):88-95 (通訊作者)

7. Yu-Ling Liu, Chia-Chi Hsu, Hui-Ju Huang, Chih-Jung Chang, Shu-Hui Sun, Anya Maan-Yuh Lin*. Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis. Mol Neurobiol. 2020 Jan;57(1):96-104.  (通訊作者)

8. Yen-Ju Chen, Chia-Chi Hsu, Young-Ji Shiao, Hsiang-Tsui Wang, Yu-Li Lo*, Anya Maan-Yuh Lin*.Anti-inflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation. Sci Rep. 2019 Feb 21;9(1):p2516. (IF=4.011; 15/69 Integrative & Complementary Medicine) (通訊作者)

9. Shu-Ting Hong , Hua-ching Lin, Chen-Shen Wang, Chih-Hsien Chang, Anya Maan-Yuh Lin, James Chih-Hsin Yang, Yu-Li Lo*. Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides. J Nanobiotechnology. 2019 Aug 19;17(1):p89. (IF= 5.345, 19/162 biotechnology and applied microbiology)

10. Wei-Zhong Zhao, Hsiang-Tsui Wang, Hui-Ju Huang, Yu-Li Lo*, Anya Maan-Yuh Lin*. Neuroprotective effects of baicalein on acrolein-induced neurotoxicity in the nigrostriatal dopaminergic system of rat brain. Mol Neurobiol. 2018 Jan;55(1):130-137 (IF=6.190; 25/259 Integrative & Complementary Medicine). (通訊作者)

11. Hui-Ju Huang, Yi-Ting Wang, Hui-Ching Lin , Yi-Hsuan Lee* , Anya Maan-Yuh Lin*.  Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. Mol Neurobiol. 2018 Jan;55(1):138-144. (通訊作者)

12. Yi-Ting Wang, Hui-Ching Lin , Wei-Zhong Zhao , Hui-Ju Huang, Yu-Li Lo, Hsiang-Tsui Wang , Anya Maan-Yuh Lin*. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Sci Rep. 2017 Apr 12; 7:p45741. (IF=4.259; 10/64 Integrative & Complementary Medicine) (通訊作者)

 

 

 

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