II. Publications (selected from 2013)

1. Lin NC, Wu HH, Ho JH*, Liu CS*, Lee OK*. Jun. 2019. Mesenchymal Stem Cells Prolong Survival and Prevent Lethal Complications in a Porcine Model of Fulminant Liver Failure. Xenotransplantation. _{(IF=3.484; TRANSPLANTATION: 9/25)} [Epub ahead of print]
2. Chu SY, Chou CH, Huang HD, Yen MH, Hong HC, Chao PH, Wang YH, Chen PY, Nian SX, Chen YR, Liou LY, Liu YC, Chen HM, Lin FM, Chang YT, Chen CC* & Lee OK.* Apr. 2019. Mechanical stretch induces hair regeneration through the alternative activation of macrophages. Nat Commun 10(1):1524. _{(IF=11.878; MULTIDISCIPLINARY SCIENCES: 5/69)}
3. Chen WT, Hsu WT, Yen MH, Changou CA, Han CL, Chen YJ, Cheng JY, Chang TH, Lee OK*, Ho JH. Jan. 2019. Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization. Biomaterials 190-191: 1-10. _{(IF=10.273; MATERIALS SCIENCE, BIOMATERIALS: 1/32)}
4. Jeng YT, Lin SY, Hu HY, Lee OK, Kuo LL*. Nov. 2018. Osteoporosis and dry eye syndrome: A previously unappreciated association that may alert active prevention of fall. PLoS ONE 13(11):e0207008. _{(IF=2.776; MULTIDISCIPLINARY SCIENCES: 24/69)}
5. Lin HI, Kuo SW, Yen TJ*, Lee OK*. Aug. 2018. SiNWs Biophysically Regulate the Fates of Human Mesenchymal Stem Cells. Sci Rep 8(1):12913. _{(IF=4.011, MULTIDISCIPLINARY SCIENCES: 15/69)}
6. Yang JC, Chen CF, Luo CA, Chang MC, Lee OK, Huang Y, Lin SC. May 2018. Clinical Experience Using a 3D-Printed Patient-Specific Instrument for Medial Opening Wedge High Tibial Osteotomy. Biomed Res Int 2018:9246529.  _{(IF=2.197; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 94/162)}
7. Chiang YH, Lin CC, Chen YC, Lee OK*. Mar. 2018. Treatment of Arsenite Intoxication-Induced Peripheral Vasculopathy with Mesenchymal Stem Cells. Int J Mol Sci 19(4): 1026. _{(IF=4.183, BIOCHEMISTRY & MOLECULAR BIOLOGY: 78/298)}
8. Wen KC , Sung PL, Chou YT, Pan CM, Wang PH*, Lee OK*, Wu CW*. Feb 2018. The role of EpCAM in tumor progression and the clinical prognosis of endometrial carcinoma. Gynecol Oncol 148(2):383-392. _{(IF=4.393; OBSTERICS & GYNECOLOGY: 8/83)}
9. Lee CW, Chen YF, Wu HH, Lee OK*. Jan 2018. Historical Perspectives and Advances in the Mesenchymal Stem Cell Research for the Treatment of Liver Diseases. Gastroenterology 154(1):46-56. _{(IF=19.233; GASTROENTEROLOGY & HEPATOLOGY: 2/84)}
10. Kuo SW, Rimando MG, Liu YS*, Lee OK*. Oct 2017. Intermittent Administration of Parathyroid Hormone 1–34 Enhances Osteogenesis of Human Mesenchymal Stem Cells by Regulating Protein Kinase Cδ. Int J Mol Sci 18(10): 2221. _{(IF=4.183, BIOCHEMISTRY & MOLECULAR BIOLOGY: 78/298)}
11. Chang CC, Chang CW, Nguyen PA, Chang TH, Shih YL, Chang WY, Horng JT, Lee OK*, Ho JH*. Aug 2017. Ankylosing spondylitis and the risk of cancer. Oncol Lett 14(2):1315-1322. _{(IF=1.981; ONCOLOGY: 186/229)}
12. Lee CW, Huang WC, Huang HD, Huang YH, Ho JH, Yang MH, Yang VW, Lee OK*. Jul 2017. DNA methyltransferases modulate hepatogenic lineage plasticity of mesenchymal stromal cells. Stem Cell Reports 9(1):247-263. _{(IF=5.499; CELL & TISSUE ENGINEERING: 5/26)}
13. Chen YC, Fan HY, Curtis JR, Lee OK, Liu CK, Huang SJ*. Jun. 2017. Determinants of receiving palliative care and ventilator withdrawal among patients with prolonged mechanical ventilation. Crit Care Med 45(10):1625-1634. _{(IF=6.971; CRITICAL CARE MEDICINE: 5/33)}
14. Liao KH, Chang SJ, Chang HC, Chien CL, Huang TS, Feng TC, Lin WW, Shih CC, Yang MH, Yang SH, Lin CH, Hwang WL*, Lee OK*. Jun. 2017. Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expression. PLoS ONE 12(6):e0179758. _{(IF=2.776; MULTIDISCIPLINARY SCIENCES: 24/69)}
15. Lee MS, Kuo LL*, Tan EC, Lee OK. Jun. 2017. Is normal-tension glaucoma a risk factor for Stroke? – A 10-year follow-up study. PLoS ONE 12(6):e0179307. _{(IF=2.776; MULTIDISCIPLINARY SCIENCES: 24/69)}
16. Yang CY, Chau YP, Chen A, Lee OK, Tarng DC, Yang AH*. May 2017. Targeting cannabinoid signaling for peritoneal dialysis-induced oxidative stress and fibrosis. World J Nephrol 6(3):111-118.
17. Wu HH, Lee OK*. May 2017. Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells. Stem Cell Res Ther 8(1):117. _{(IF=4.627; MEDICINE, RESEARCH & EXPERIMENTAL: 32/136)}
18. Lee IH, Huang SS, Chuang CY, Liao KH, Chang LH, Chuang CC, Su YS, Lin HJ, Hsieh JY, Su SH, Lee OK, Kuo HC*. May 2017. Delayed epidural transplantation of human induced pluripotent stem cell-derived neural progenitors enhances functional recovery after stroke. Sci Rep 7(1):1943. _{(IF=4.011, MULTIDISCIPLINARY SCIENCES: 15/69)}
19. Wen KC, Sung PL, Hsieh SL, Chou YT, Lee OK, Wu CW, Wang PH*. Apr. 2017. α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells. Oncotarget 8(17):29013-29027.
20. Tsao YT, Shih YY, Liu YA, Liu YS*, Lee OK*. Feb. 2017. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates the magnesium inhibition during the osteogenesis of mesenchymal stromal cells. Stem Cell Res Ther 8(1):39. _{(IF=4.627; MEDICINE, RESEARCH & EXPERIMENTAL: 32/136)}
21. Tsai YA, Liu RS, Lirng JF, Yang BH, Chang CH, Wang YC, Wu YS, Ho JH, Lee OK*, Soong BW*. Mar. 2017. Treatment of spinocerebellar ataxia with mesenchymal stem cells: A phase I-IIa clinical study. Cell Transplantation 26(3):503-512. _{(IF=3.477; TRANSPLANTATION: 10/25)}
22. Tsao YT, Huang YJ, Wu HH, Liu YA, Liu YS* and Lee OK*. Jan. 2017. Osteocalcin mediates biomineralization during osteogenic maturation in human mesenchymal stromal cells. Int J Mol Sci 18(1):159. _{(IF=4.183, BIOCHEMISTRY & MOLECULAR BIOLOGY: 78/298)}
23. Lee CW, Hsiao WT, Lee OK*. Nov. 2016. Mesenchymal stromal cell-based therapies reduce obesity and metabolic syndromes induced by a high-fat diet. Transl Res 182:61-74. _{(IF=4.915, MEDICINE, GENERAL & INTERNAL: 19/160)}
24. Rimando MG, Wu HH, Liu YA, Lee CW, Kuo SW, Lo YP, Tseng KF*, Liu YS* and Lee OK*. Nov. 2016. Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs). Sci Rep 6:37371. _{(IF=4.011, MULTIDISCIPLINARY SCIENCES: 15/69)}
25. Yang YH, Hsieh TL, Ji AT, Hsu WT, Liu CY, Lee OK, Ho JH*. Oct. 2016. Stromal tissue rigidity promotes mesenchymal stem cell-mediated corneal wound healing through the transforming growth factor β signaling pathway. Stem Cells 34:2525–2535. _(IF=5.614; _{BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 17/162)}
26. Chen YQ, Liu YS, Liu YA, Wu YC, del Álamo JC, Chiou A, Lee OK*. Aug. 2016. Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation. Sci Rep 6:31547. _{(IF=4.011, MULTIDISCIPLINARY SCIENCES: 15/69)}
27. Yen MH, Wu YY, Lin YS, Rimando MG, Ho JH*, Lee OK*. Aug. 2016. Efficient generation of hepatic cells from mesenchymal stromal cells by an innovative bio-microfluidic cell culture device. Stem Cell Res Ther 7(1):120. _{(IF=4.627; MEDICINE, RESEARCH & EXPERIMENTAL: 32/136)} (Cover Feature)
28. Chou PH, Wang ST, Ma HL, Liu CL, Chang MC, Lee OK*. Jul. 2016. Development of a two-step protocol for culture expansion of human annulus fibrosus cells with TGF-β1 and FGF-2. Stem Cell Res Ther 7(1):89. _{(IF=4.627; MEDICINE, RESEARCH & EXPERIMENTAL: 32/136)}
29. Yang YS, Chin YT, Hsieh MT, Lai HY, Ke CC, Crawford DR, Lee OK, Fu E, Mousa SA, Grasso P, Liu LF, Chang HY*, Tang HY, Lin HY*, Davis PJ. Mar. 2016. Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin. Oncotarget 7(19):27641-54.
30. Hsieh WT, Liu YS, Lee YH, Rimando MG, Lin KH, Lee OK*. Mar. 2016. Matrix dimensionality and stiffness cooperatively regulate osteogenesis of mesenchymal stromal cells. Acta Biomater 32:210-22. _{(IF=6.638; ENGINEERING, BIOMEDICAL: 7/80)}
31. Chou PH, Wang ST, Yen MH, Liu CL, Chang MC, Lee OK*. Feb. 2016. Fluid-induced, shear stress-regulated extracellular matrix and matrix metalloproteinase genes expression on human annulus fibrosus cells. Stem Cell Res Ther 7(1):34. _{(IF=4.627; MEDICINE, RESEARCH & EXPERIMENTAL: 32/136)}
32. Lo YP, Liu YS, Rimando MG, Ho JH, Lin KH, and Lee OK*. Feb. 2016. Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells. Sci Rep 6:21253. _{(IF=4.011, MULTIDISCIPLINARY SCIENCES: 15/69)}
33. Chou PH, Ma HL, Liu CL, Wang ST*, Lee OK, Chang MC, Yu WK. Jan. 2016. Is removal of the implants needed after fixation of burst fractures of the thoracolumbar and lumbar spine without fusion? a retrospective evaluation of radiological and functional outcomes. Bone Joint J 98-B(1):109-16. _{(IF=4.301; ORTHOPEDICS: 6/76)}
34. Wu HH, Ho JH, Lee OK*. Jan. 2016. Detection of hepatic maturation by Raman spectroscopy in mesenchymal stromal cells undergoing hepatic differentiation. Stem Cell Res Ther 7(1):6. _{(IF=4.627; MEDICINE, RESEARCH & EXPERIMENTAL: 32/136)}
35. Liu YS, Liu YA, Huang CJ, Yen MH, Tseng CT, Chien S, Lee OK*. Nov. 2015. Mechanosensitive TRPM7 mediates shear stress and modulates osteogenic differentiation of mesenchymal stromal cells through Osterix pathway?.? Sci Rep 5:16522. _{(IF=4.011, MULTIDISCIPLINARY SCIENCES: 15/69)}
36. Yang CY, Chang ZF, Chau YP, Chen A, Lee OK*, and Yang AH*. Nov. 2015. Uremia induces dental pulp ossification but reciprocally inhibits adjacent alveolar bone osteogenesis. Calcified Tissue Int. 97(5):466-75. _{(IF=3.265; ENDOCRINOLOGY & METABOLISM: 67/145)}
37. Wang HL, Yang CH, Lee HH, Kuo JC, Hur SS, Chien S, Lee OK, Hung SC, Chang ZF*. Oct. 2015. Dexamethasone-induced cellular tension requires SGK1-stimulated Sec5/GEF-H1 interaction. J Cell Sci 128(20):3757-68. _{(IF=4.517; CELL BIOLOGY: 65/193)}
38. Chang CC, Hsieh TL, Tiong TY, Hsiao CH, Ji AT, Hsu WT, Lee OK*, Ho JH*. Aug. 2015. Regulation of metastatic ability and drug resistance in pulmonary adenocarcinoma by matrix rigidity via activating c-Met and EGFR. Biomaterials 60:141-50 _{(IF=10.273; MATERIALS SCIENCE, BIOMATERIALS: 1/32)}
39. Yang CY, Chang ZF, Chau YP, Chen A, Yang WC, Yang AH*, and Lee OK*. Aug. 2015. Circulating Wnt/β-catenin signaling inhibitors and uremic vascular calcifications. Nephrol Dial Transpl. 30(8):1356-63 _{(IF=4.198; UROLOGY & NEPHROLOGY: 12/80)}
40. Chiang YH, Wu SH, Kuo YC, Chen HF, Chiou A, Lee OK*. Apr. 2015. Raman spectroscopy for grading of live osteosarcoma cells. Stem Cell Res Ther 6:81. _{(IF=4.627; MEDICINE, RESEARCH & EXPERIMENTAL: 32/136)}
41. Teng NY, Liu YS, Wu HH, Liu YA, Ho JH*, Lee OK*. Apr. 2015. Promotion of mesenchymal-to-epithelial transition by Rac1 inhibition with small molecules accelerates hepatic differentiation of mesenchymal stromal cells. Tissue Eng Part A 21(7-8):1444-54 _{(IF=3.616; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 43/162)}
42. Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S, Widelitz RB, Lander AD, Chuong CM*. Apr. 2015. Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell 161(2):277-90 _{(IF=36.216; BIOCHEMISTRY & MOLECULAR BIOLOGY: 1/298)}
43. Ji AT, Chang YC, Fu YJ, Lee OK*, Ho JH*. Mar. 2015. Niche-dependent regulations of metabolic balance in high-fat diet induced diabetic mice by mesenchymal stromal cells. Diabetes 64(3):926-36 _{(IF=7.199; ENDOCRINOLOGY & METABOLISMS: 11/145)}
44. Kuo YC, Chang TH, Hsu WT, Zhou J, Lee HH, Ho JH*, Chien S*, Lee OK*. Feb. 2015. Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells. Stem Cells 33(2):429-42 _{(IF=5.614; BIOTECHNOLOGY & APPLIED MICROBIOLOGY: 17/162)}
45. Guo HW, Yu JS, Hsu SH, Wei YH, Lee OK, Dong CY*, Wang HW*. Jan. 2015. Correlation of NADH fluorescence lifetime and oxidative phosphorylation metabolism in the osteogenic differentiation of human mesenchymal stem cell. J Biomed Opt 20(1):017004  _{(IF=2.555; OPTICS: 37/95)}
46. Chen CC, Murray PJ, Jiang TX, Plikus MV, Chang YT, Lee OK, Widelitz RB, Chuong CM*. Aug. 2014. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, Dkk1 and Sfrp4. J Invest Dermatol 134(8):2086-96 _{(IF=6.290; DERMATOLOGY: 4/66)}
47. Cheng MT, Liu CL, Chen TH, Lee OK*. Jul. 2014. Optimization of culture conditions for stem cells derived from human anterior cruciate ligament and bone marrow. Cell Transplantation 23(7):791-803 _{(IF=3.477; TRANSPLANTATION: 10/25)}
48. Chang TH, Huang HD, Ong WK, Fu YJ, Lee OK, Chien S, Ho JH*. Apr. 2014. The effects of actin cytoskeleton perturbation on keratin intermediate filament formation in mesenchymal stem/stromal cells. Biomaterials 35(13):3934-44 _{(IF=10.273; MATERIALS SCIENCE, BIOMATERIALS: 1/32)}
49. Jiang WC, Cheng YH, Yen MH, Chang Yin, Yang VW, Lee OK*. Apr. 2014. Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering. Biomaterials 35(11):3607-3617 _{(IF=10.273; MATERIALS SCIENCE, BIOMATERIALS: 1/32)}
50. Tsai HL, Chang JW*, Liu CS, Chin TW, Wei CF, Lee OK, Wang SJ. Mar. 2014. A newly designed total implantable venous access device in rats for research with high efficiency and low cost. J Surg Res 187(1):36-42 _{(IF=1.872; SURGERY: 104/203)}
51. Shih YV, Hwang YS, Phadke A, Kang H, Hwang N, Caro EJ, Nguyen S, Siu M, Theodoraki EA, Gianneschi N, Vecchio K, Chien S*, Lee OK*, Varghese S*. Jan. 2014. Calcium-phosphate bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. P Natl Acad Sci USA 111(3):990-995 _{(IF=9.580; MULTIDISCIPLINARY SCIENCES: 7/69)}
52. Liu YS, Lee OK*. Jan. 2014. In search of the pivot point of mechanotransduction: Mechanosensing of stem cells. Cell Transplantation 23(1):1-11 (review) _{(IF=3.477; TRANSPLANTATION: 10/25)}
53. Kuo CH, Liu CJ, Lu CY, Hu HM, Kuo FC, Liou YS, Yang YC, Hsieh MC, Lee OK, Wu DC, Wang SS, Chen YL*. Dec. 2013. 17β-estradiol inhibits mesenchymal stem cells-induced human AGS gastric cancer cell mobility via suppression of CCL5- Src/Cas/Paxillin signaling pathway. Int J Med Sci 11(1): 7-16 _{(IF=2.333; MEDICINE, GENERAL & INTERNAL: 53/160)}
54. Hua WK, Shiau YH, Lee OK, Lin WJ*. Dec. 2013. Elevation of protein kinase Cα stimulates osteogenic differentiation of mesenchymal stem cells through the TAT-mediated protein transduction system. Biochem Cell Biol 91(6):443-8 _{(IF=2.014; BIOCHEMISTRY & MOLECULAR BIOLOGY: 221/298)}
55. Hsieh JY, Huang TS, Cheng SM, Lin WS, Tsai TN, Lee OK*, Wang HW*. Nov. 2013. miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells. Nucleic Acids Res 41(21):9753-63 _{(IF=11.147; BIOCHEMISTRY & MOLECULAR BIOLOGY: 14/298)}
56. Hung SP, Yang MH, Tseng KF*, Lee OK*. Oct. 2013. Hypoxia-induced secretion of TGF-beta 1 in mesenchymal stem cell promotes breast cancer cell progression. Cell Transplantation 22(10):1869-82 _{(IF=3.477; TRANSPLANTATION: 10/25)}
57. Tsai HL, Chang JW, Yang HW, Chen CW, Yang CC, Yang AH, Liu CS, Chin TW, Wei CF, Lee OK*. Sep. 2013. Amelioration of paraquat-induced pulmonary injury by mesenchymal stem cells. Cell Transplantation 22(9):1667-81 _{(IF=3.477; TRANSPLANTATION: 10/25)}
58. Kuo YC, Li YS, Zhou J, Shih YR, Miller M, Broide D, Lee OK*, Chien S*. Aug. 2013. Human mesenchymal stem cells suppress the stretch-induced inflammatory miR-155 and cytokines in bronchial epithelial cells. PLoS ONE 8(8):e71342  _{(IF=2.776; MULTIDISCIPLINARY SCIENCES: 24/69)}
59. Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK*, Hoffman RM*. Jul. 2013. In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells. PLoS ONE 8(7):e69658  _{(IF=2.776; MULTIDISCIPLINARY SCIENCES: 24/69)}
60. Chen HW, Chen HY, Wang LT, Wang FH, Fang LW, Lai HY, Chen HH, Lu J, Hung MS, Cheng Y, Chen MY, Liu SJ, Chong P, Lee OK, Hsu SC*. May 2013. Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines. J Immunol 190(10):5065-77 _{(IF=4.718; IMMUNOLOGY: 42/158)}
61. Hung PS, Kuo YC, Chen HG, Chiang KH, Lee OK*. May 2013. Detection of osteogenic differentiation by differential mineralized matrix production in mesenchymal stromal cells by Raman spectroscopy. PLoS ONE 8(5):e65438  _{(IF=2.776; MULTIDISCIPLINARY SCIENCES: 24/69)}
62. Ong WK, Chen HF, Tsai CT, Fu YJ, Wong YS, Yen DJ, Chang TH, Huang HD, Lee OK, Chien S, Ho JH*. Mar. 2013. The activation of directional stem cell motility by green light-emitting diode irradiation. Biomaterials 34(8):1911-20 _{(IF=10.273; MATERIALS SCIENCE, BIOMATERIALS: 1/32)}
63. Ho JH*, Lee OK, Fu YJ, Shih HT, Tseng CY, Chung CC, Han CL, Chen YJ*. Mar. 2013. An iTRAQ proteomic study reveals an association between diet-induced enhanced fatty-acid metabolism and the development of glucose intolerance in prediabetic mice. J Proteome Res 12(3):1120-33 _{(IF=3.780; BIOCHEMICAL RESEARCH METHODS: 15/79)}
64. Yang CY, Chau YP, Lee HT, Kuo HY, Lee OK, Yang AH*. Jan. 2013. Cannabinoid receptors as therapeutic targets for dialysis-induced peritoneal fibrosis. Am J Nephrol 37(1):50-8 _{(IF=2.961; UROLOGY & NEPHROLOGY: 20/80)}
65. Ke CC, Liu RS, Yang AH, Liu CS, Chi CW, Tseng LM, Tsai YF, Ho JH, Lee CH, Lee OK*. Jan. 2013. CD133-expressing thyroid cancer cells are undifferentiated, radioresistant and survive radioiodide therapy. Eur J Nucl Med Mol I 40(1):61-71  _{(IF=7.182; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING: 6/129)}
66. Hsu SC*, Wang LT, Yao CL, Lai HY, Chan KY, Liu BS, Chong P, Lee OK, Chen HW*. Jan. 2013. Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4⁺ CD45RO⁺ T cells. Immunobiology 218(1):90-95 _{(IF=2.798; IMMUNOLOGY: 96/158)}