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▍骨骼肌肉腫瘤治療暨研究中心
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吳博貴 中心主任

吳博貴 科主任   Po-Kuei Wu, Prof.

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現職
教育部 部定教授
國立陽明交通大學醫學院  教授
臺北榮民總醫院骨科部  關節重建科  科主任
臺北榮民總醫院骨科部  骨骼肌肉腫瘤治療研究中心  主任
中華民國骨肉癌關懷協會 理事長
亞太骨腫瘤會議 理事
骨骼肌肉腫瘤研習營 講師
亞太關節重建醫學會（APAS）會員
國際惡性骨腫瘤暨肢體保留學會（ISOLS）會員

學歷
國立陽明交通大學臨床醫學研究所 醫學博士
國立陽明大學醫學系畢業

經歷
美國梅約醫學中心 (Mayo Clinic）骨腫瘤中心 訪問學者
美國梅約醫學中心 (Mayo Clinic）關節重建科 訪問學者
美國梅約醫學中心 (Mayo Clinic）生物組織工程實驗室 研究員
日本金澤大學 Kanazawa University） 臨床研究員
臺北榮民總醫院骨科部 主治醫師
臺北榮民總醫院骨科部 臨床研究醫師
臺北榮民總醫院骨科部 總醫師
臺北榮民總醫院骨科部 住院醫師

專長
微創人工關節置換手術
人工關節重新翻修手術
骨骼肌肉系統腫瘤治療
各類關節炎治療
軟組織腫瘤治療
間葉幹細胞基礎研究
腫瘤冷凍治療基礎研究

專利發明
生物性冷凍裝置
治療腫瘤組合物
冷凍處理中保護生物組織的防凍劑及其製備方法​
小粒徑聚乙二醇化微脂體及其製備方法

獲獎事蹟
2021 : 生策會 國家新創獎
2021 : 國立陽明交通大學 院級教學傑出獎
2019 : 全球骨腫瘤大會(ISOLS)Flash Presentation第一名
2019 : 臺北榮民總醫院 醫療創新獎
2016 : 中華民國骨科醫學會年度度會優秀論文比賽口頭論文第一名
2016 : 中華民國骨科醫學會年度度會優秀論文比賽口頭論文佳作
2007 : 中華民國骨科醫學會年度度會優秀論文比賽口頭論文第一名

研究
『僅列出Science Citation Index 已正式發表之文章』

  1. 2022 Jun. Pharmacological thromboprophylaxis as a risk factor for early periprosthetic joint infection following primary total joint arthroplasty. 
  2. 2022 Jun. The effective distance and cooling rate of liquid nitrogen-based adjunctive cryotherapy for bone tumors ex vivo. 
  3. 2022 Apr. Patella cryo-free technique with recycled frozen autograft reconstruction preserves extensor mechanism for proximal tibial malignancy. 
  4. 2022 Mar. Is there a role for cementless primary stem in hip arthroplasty for early or late fixation failures of intertrochanteric fractures? 
  5. 2021 Dec. Biomechanical Analysis and Design Method for Patient-Specific Reconstructive Implants for Large Bone Defects of the Distal Lateral Femur. 
  6. 2021 Nov. Comparable outcomes of recycled autografts and allografts for reconstructions in patients with high-grade osteosarcoma. 
  7. 2021 Nov. Uncemented femoral stem design might have an impact on postoperative periprosthetic femur fracture pattern. A Comparison between flat-wedge and dual-wedge stems.
  8. 2021 Oct. Suppression of Estrogen Receptor Alpha Inhibits Cell Proliferation, Differentiation and Enhances the Chemosensitivity of P53-Positive U2OS Osteosarcoma Cell.
  9. 2021 Oct. Does the Addition of iPACK Block to Adductor Canal Block Provide Improved Analgesic Effect in Total Knee Arthroplasty? A Systematic Review and Meta-Analysis.
  10. 2021 Aug. Characterization of Osteogenesis and Chondrogenesis of Human Decellularized Allogeneic Bone with Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Wharton's Jelly. 
  11. 2021 Aug. Significantly reducing blood loss via a peri-articular injection of tranexamic acid during total knee arthroplasty: a retrospective study.
  12. 2021 Aug. Dialysis patients have comparable results to patients who have received kidney transplant after total joint arthroplasty: a systematic review and meta-analysis.
  13. 2021 Aug. Comparison of recycled autograft versus allograft in osteosarcoma with pathological fracture. 
  14. 2021 Jun. Effect of Cryoablation Treatment on the Protein Expression Profile of Low-Grade Central Chondrosarcoma Identified by LC-ESI-MS/MS. 
  15. 2021 May. Cementation of the highly cross-linked polyethylene liner into a well-fixed acetabular shell to treat patients with recurrent dislocation after total hip arthroplasty.  
  16. 2021 Apr. An opioid-sparing protocol with intravenous parecoxib can effectively reduce morphine consumption after simultaneous bilateral total knee arthroplasty. 
  17. 2021 Apr. Impact of screening COVID-19 on orthopedic trauma patients at the emergency department: A consecutive series from a level I trauma center.
  18. 2021 Feb. Outcomes of dual-mobility total hip arthroplasty versus bipolar hemiarthroplasty for patients with femoral neck fractures: a systematic review and meta-analysis.
  19. 2021 Feb. Uncemented femoral stem design might have an impact on postoperative periprosthetic femur fracture pattern. A Comparison between flat-wedge and dual-wedge stems.
  20. 2021 Feb. Impact of screening COVID-19 on orthopedic trauma patients at the emergency department: A consecutive series from a level I trauma center.
  21. 2020 Dec.Cementation of the highly cross-linked polyethylene liner into a well-fixed acetabular shell to treat patients with recurrent dislocation after total hip arthroplasty.
  22. 2020 Nov. Exploring the Proteomic Alterations from Untreated and Cryoablation and Irradiation Treated Giant Cell Tumors of Bone Using Liquid-Chromatography Tandem Mass Spectrometry.
  23. 2020 Oct. Low rates of all-cause revision in displaced subcapital femoral neck fractures treated with hip hemiarthroplasty - a retrospective review of 4516 patients from a single institute.
  24. 2020 Aug. Total elbow arthroplasty in patients with rheumatoid arthritis.
  25. 2020 Jul. Adjuvant therapy by high-speed burr may cause intraoperative bone tumor seeding: an animal study.
  26. 2020 Jul. Prognostic factors and survival in conventional chondrosarcoma: A single institution review.
  27. 2020 Feb. The efficacy of continuous versus single-injection femoral nerve block in Total knee Arthroplasty: a systematic review and meta-analysis.
  28. 2020 Feb. Proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryotherapy and irradiation.
  29. 2020Jun. Is short-course systemic antibiotic therapy using an antibiotic-loaded cement spacer safe after resection for infected total knee arthroplasty? A comparative study.
  30. 2019 Dec. Outcomes following total elbow arthroplasty for rheumatoid arthritis versus post-traumatic conditions: a systematic review and meta-analysis.
  31. 2019 Oct. Outcomes of internal fixation versus hemiarthroplasty for elderly patients with an undisplaced femoral neck fracture: a systematic review and meta-analysis.
  32. 2019 Oct. The efficacy and safety of continuous versus single-injection popliteal sciatic nerve block in outpatient foot and ankle surgery: a systematic review and meta-analysis.
  33. 2019 Oct. Expression profile?driven discovery of AURKA as a treatment target for liposarcoma. Int J Oncol.
  34. 2019 Jun. Suboptimal outcomes after internal fixation for displaced intracapsular femoral neck fractures in 50- to 60-year-old patients. Hip Int.
  35. 2019 Jun. The efficacy of intraoperative periarticular injection in Total hip arthroplasty: a systematic review and meta-analysis. BMC Musculoskelet Disord.
  36. 2019 Aug. Bone morphogenetic protein activity preservation with extracorporeal irradiation- and liquid nitrogen freezing-treated recycled autografts for biological reconstruction in malignant bone tumor. Cryobiology.
  37. 2019 Jul. Analysis of learning curve of minimally invasive total knee arthroplasty: A single surgeon's experience with 4017 cases over a 9-year period. J Chin Med Assoc
  38. 2019 Feb. The mid-term outcome of dialysis-dependent patients undergoing primary total knee arthroplasty and total hip arthroplasty: A retrospective study. J Chin Med Assoc.
  39. 2019 Jan. Does continued aspirin mono-therapy lead to a higher bleeding risk after total knee arthroplasty? J Chin Med Assoc.
  40. 2018 Jul. Printing a 3-dimensional, Patient-specific Splint for Wound Immobilization: A Case Demonstration. Ostomy Wound Manage.
  41. 2018 Aug. A safety comparative study between freezing nitrogen ethanol composite and liquid nitrogen for cryotherapy of musculoskeletal tumors. Cryobiology.  
  42. 2018 Sep. Optimal timing for elective total hip replacement in HIV-positive patients. Orthop Traumatol Surg Res.
  43. 2018 Jul. Grafting for bone defects after curettage of benign bone tumor - Analysis of factors influencing the bone healing. J Chin Med Assoc. 
  44. 2018 Aug. Alveolar soft part sarcoma: Clinical presentation, treatment, and outcome in a series of 13 patients. J Chin Med Assoc
  45. 2018 Apr. Intraoperative Extracorporeal Irradiation and Frozen Treatment on Tumor-bearing Autografts Show Equivalent Outcomes for Biologic Reconstruction.
  46. 2018 Jun. Cement augmentation in the proximal femur to prevent stem subsidence in revision hip arthroplasty with Paprosky type II/IIIa defects. J Chin Med Assoc.
  47. 2017 Dec. Prognosis-Based Shoulder Hemiarthroplasty After Resection of Proximal Humeral Malignancy. Artif Organs.
  48. 2018 Feb. Revision Total Knee Arthroplasty Using a Constrained Condylar Knee Prosthesis Combined with a Posterior Stabilized Articular Surface. J Knee Surg.
  49. 2017 Dec. Partial component-retained two-stage reconstruction for chronic infection after uncemented total hip arthroplasty: results of sixteen cases after five years of follow-up. Int Orthop.
  50. 2017 Jun. Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity. Stem Cells Transl Med.
  51. 2017 Jun. Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone. Clin Orthop Relat Res.
  52. 2017 Feb. Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells. Stem Cells Transl Med.
  53. 2016 Dec. Pathological fractures in predicting clinical outcomes for patients with osteosarcoma. BMC Musculoskelet Disord.
  54. 2017 Mar. Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study. J Chin Med Assoc.
  55. 2017 Jun. Postoperative Ambulatory Performance Status Significantly Affects Implant Failure Rate Among Surgical Treatment Strategies in Patients With Proximal Femur Metastasis. Artif Organs.
  56. 2016 May. Outcomes of 50 Patients With Ewing Sarcoma Family of Tumors Treated at a Single Institution in Taiwan. Medicine (Baltimore).
  57. 2016 Apr. Improvement in High-Grade Osteosarcoma Survival: Results from 202 Patients Treated at a Single Institution in Taiwan. Medicine (Baltimore).
  58. 2016 Aug. Does Implant Selection Impact Postoperative Complications Following Hip Arthroplasty for Failed Intertrochanteric Fractures? A Retrospective Comparative Study. Artif Organs.
  59. 2016 Jan. Etiologies and outcome of osteonecrosis of the femoral head: Etiology and outcome study in a Taiwan population. J Chin Med Assoc.
  60. 2015 Jul. Calcified Coracoacromial Ligament. Intern Med.
  61. 2015 Oct. Total Hip Arthroplasty for Patients Who Have Ankylosing Spondylitis: Is Postoperative Irradiation Required for Prophylaxis of Heterotopic Ossification? J Arthroplasty.
  62. 2015 Oct. Zoledronic acid-loaded bone cement as a local adjuvant therapy for giant cell tumor of the sacrum after intralesional curettage. Eur Spine J.
  63. 2015 May. Modified anterolateral approach in minimally invasive total hip arthroplasty. Hip Int.
  64. 2014 Dec. Acremonium species combined with Penicillium species infection in hip hemiarthroplasty: a case report and literature review. Hip Int.
  65. 2015 Jan. Bone-prosthesis composite with rotating hinged-knee prosthesis in limb salvage surgery for high-grade sarcoma around the knee. J Arthroplasty.
  66. 2014 Aug. Nonpalpable intramuscular hemangioma treated with hookwire localization and excision. J Chin Med Assoc.
  67. 2014 Jul. Wake-up test in total hip arthroplasty with high-riding developmental dysplasia. Orthopedics.
  68. 2014 May. Manipulation therapy prior to diagnosis induced primary osteosarcoma metastasis--from clinical to basic research. PLoS One.
  69. 2014 May. Population-based epidemiology of postoperative venous thromboembolism in Taiwanese patients receiving hip or knee arthroplasty without pharmacological thromboprophylaxis. Thromb Res.
  70. 2014 Mar. Pulmonary embolism following total knee arthroplasty in Taiwanese patients.J Chin Med Assoc.
  71. 2013 Oct. Osteomyelitis of the femur mimicking bone tumors: a review of 10 cases. World J Surg Oncol.
  72. 2013 Feb. Osteoblastoma in the region of the hip. J Chin Med Assoc.
  73. 2012 Aug. Effectiveness of plate augmentation for femoral shaft nonunion after nailing. J Chin Med Assoc.
  74. 2012 Jul. Extensively porous-coated stems for femoral revision: reliable choice for stem revision in Paprosky femoral type III defects. Orthopedics.
  75. 2012 Sep. No significant squeaking in total hip arthroplasty: a series of 413 hips in the Asian people. J Arthroplasty.
  76. 2012 Jun. Simultaneous anterior and posterior synovectomies for treating diffuse pigmented villonodular synovitis. Clin Orthop Relat Res.
  77. 2012 Jan. Clinical outcomes and prognostic factors of Ewing sarcoma: a clinical analysis of 12 patients in Taiwan. J Chin Med Assoc.
  78. 2012 Jun. High-grade osteosarcoma treated with hemicortical resection and biological reconstruction. J Surg Oncol.
  79. 2011 Nov. The prognosis of patients with primary osteosarcoma who have undergone unplanned therapy. Jpn J Clin Oncol.
  80. 2012 Jul. Pelvic hemophilic pseudotumor presenting as severe sciatic pain in a patient with no history of hemophilic symptoms. J Orthop Sci.
  81. 2010 Dec. In brief: Crowe's classification: arthroplasty in developmental dysplasia of the hip.Clin Orthop Relat Res.
  82. 2009 Aug. Primary osteogenic sarcoma with pulmonary metastasis: clinical results and prognostic factors in 91 patients. Jpn J Clin Oncol.

國外學會發表

  1. 2019. International Society Of Limb Salvage, 20TH (Athens, Greece): Comparative proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryoablation and irradiation
  2. 2019. International Society Of Limb Salvage, 20TH (Athens, Greece): Pedicle Freezing by “Freezing Tank” for biological reconstruction of limb sarcoma
  3. 2019. International Society Of Limb Salvage, 20TH (Athens, Greece):  Intraoperative extracorporeal irradiation and frozen treatment on tumor-bearing autografts show equivalent outcomes for biologic reconstruction
  4. 2018. Asia Pacific Musculoskeletal Tumor Society, 12th (India, Jaipur): Comparative study between Allograft & Recycled Autografts for Biological Reconstruction of High-grade Osteosarcoma.
  5. 2018. Asia Pacific Musculoskeletal Tumor Society, 12th (India, Jaipur): Comparison of the Activity Preservation for BMP between ECIR- and Freezing- Treated Autografts Used for Biological Reconstruction.
  6. 2018. Asia Pacific Musculoskeletal Tumor Society, 12th (India, Jaipur): Safety and Efficacy Validation of Patella Cryo-free Method during Recycled Frozen Autograft Procedure for Proximal Tibia Malignant Bone Tumors.
  7. 2018. Congtrso Multimedica Interisciplinaria (Guatemala, Guatemala city): Cryotherapy for Benign Bone Tumor.
  8. 2018. Congtrso Multimedica Interisciplinaria (Guatemala, Guatemala city): Biological Reconstruction for Bone Sarcoma.
  9. 2017. International Society of Limb Salvage (Japan, Kanazawa): Comparative study between allograft and recycled autografts for biological reconstruction of high-grade Osteosarcoma.
  10. 2017. International Society of Limb Salvage (Japan, Kanazawa): Cryotherapy for Giant Cell Tumor of Bone (GCT) by Freezing Nitrogen Ethanol Composite (FNEC): Animal study.
  11. 2017. International Society of Limb Salvage (Japan, Kanazawa): Activity of bone morphogenetic protein-2 after treatment by biological reconstruction.
  12. 2016. China Orthopedics Association (China, Beijing):Use of a novel Freezing Nitrogen Ethanol Composite (FNEC) as adjuvant cryotherapy for treating giant cell tumor of bone (GCT)
  13. 2016. China Orthopedics Association (China, Beijing):Comparative study between allograft and recycled autografts for biological reconstruction of high-grade Osteosarcoma.
  14. 2015. International Society of Limb Salvage (USA, Orlando): Effect of Composite Gel Cryoprotectant on Cryopreservation of Cartilage Tissues during Biological Reconstruction with Frozen Osteochondral Autograft.
  15. 2015. International Society of Limb Salvage (USA, Orlando): Skeletally immature child with osteogenic sarcoma over proximal femur treated with adult humeral osteochondral allograft.
  16. 2015. International Society of Limb Salvage (USA, Orlando): Patella Cryoprotection During Liquid Nitrogen Freezing in Limb-salvage Procedure of Proximal Tibia Bone Tumors.
  17. 2013. International Society of Limb Salvage (Italy): The Prognosis of Patients with Primary Osteosarcoma Who Have Undergone Unplanned Therapy.
  18. 2013. International Society of Limb Salvage (Italy): Bone and Rotating-Hinge Prosthesis Composite Reconstruction after Resection of Meta-epiphyseal Sarcoma of the Knee.
  19. 2013. International Society of Limb Salvage (Italy): Simultaneous Anterior and Posterior Synovectomies for Treating Diffuse Pigmented Villonodular Synovitis.
  20. 2013. American Academy of Orthopaedic Surgeons, AAOS (U.S.A, Chicago):  The Prognosis of Patients with Primary Osteosarcoma Who Have Undergone Unplanned Therapy.
  21. 2012. Asia Pacific Musculoskeletal Tumor Society (Singapore): The Prognosis of Patients with Primary Osteosarcoma Who Have Undergone Unplanned Therapy.
  22. 2011. International Society of Limb Salvage (China, Beijing):  The effect of manipulative therapy for osteosarcoma: A clinical and animal study.
  23. 2010. Asia-Pacific Arthroplasty Society Annual Meeting (India): Prophylaxis in Pulmonary Embolism After Total Joint Replacement.
  24. 2009, International Society of Limb Salvage (U.S.A, Boston): Innovative trident fixation technique for allograft knee arthrodesis for high grade osteosarcoma around the knee.
  25. 2009. International Society of Limb Salvage (U.S.A, Boston): Grafting for Bone Defects after Curettage of Non-aggressive Benign Bone Tumors - Analysis of Factors Influencing the Bone healing.
  26. 2009. International Society of Limb Salvage (U.S.A, Boston): Hemicortical Resection and Bone Graft Reconstruction for High Grade Osteosarcoma.
  27. 2009. International Society of Limb Salvage (U.S.A, Boston): Epiphyseal preservation and biological reconstruction in high-grade osteosarcoma of the knee.
  28. 2009. International Society of Limb Salvage (U.S.A, Boston): Hemicortical Resection and Bone Graft Reconstruction for High Grade Osteosarcoma.
  29. 2007. International Society of Limb Salvage (German, Hamburg): Prognostic Analysis in Patients of Primary Osteogenic Sarcoma With Previous Traditional Therapy.
  30. 2005. International Society of Limb Salvage (Korea): Prognostic Factors in Primary High-Grade Osteosarcoma.

國內學會發表

1. 2005年 中華骨科醫學會: Prognostic Factors in Primary High-Grade Osteosarcoma – An Analysis of 123 Patients (優秀論文)

2. 2006年 中華骨科醫學會: Primary Osteogenic Sarcoma with lung metastasis – Clinical Experience in Taipei Veterans General Hospital (優秀論文)

3. 2007年 中華骨科春季醫學會: Primary Osteogenic Sarcoma with Pulmonary Metastasis - A study of clinical results and prognostic factors in 91 patients. (優秀論文比賽第一名)

4. 2007年 中華骨科醫學會: Prognostic Analysis in Patients of Primary Osteogenic Sarcoma With Previous Traditional Therapy. (優秀論文)

5. 2007年 台北榮總與台大論文交流: Prognostic Analysis in Patients of Primary Osteogenic Sarcoma With Previous Traditional Therapy.

6. 2008年 中華骨科醫學會: Hemicortical Resection and Bone Graft Reconstruction for High Grade Osteosarcoma. (優秀論文)

7. 2008年 台北榮總與台大論文交流: Hemicortical Resection and Bone Graft Reconstruction for High Grade Osteosarcoma.

8. 2009年 中華骨科春季醫學會: Allograft Versus Bone Substitute for Benign Bone Lesion.

9. 2012年 中華骨科醫學會: Synovial Sarcoma in the Pelvis.

10. 2013年 中華骨科春季醫學會: Adjuvant Therapy for Giant Cell Tumor of Bone.

11. 2013年 中華骨科春季醫學會: Treatment Options for Extra-abdominal Musculoskeletal Desmoid Tumor.

12. 2014年 中華骨科醫學會: Cement Retention in Total Knee Replacement.

13. 2014年 中華骨科醫學會: Limb Salvage for Recurrent Osteosarcom

14. 2014年 兩岸骨科醫學會：Cryotherapy in VGHTPE

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