兒童血液腫瘤科主任 顏秀如 主任

兒童血液腫瘤科 專長: 兒童及青少年血液腫瘤 造血幹細胞移植 血液凝固疾病 新生兒血液疾病 新生兒學 門診時刻表

 

研究

 

1. 探討兒童白血病或淋巴癌之化學治療結果、危險分析、及異體造血幹細胞移植

2. 探討兒童高危險腦瘤之治療及造血幹細胞移植之結果及預後分析

3. 探討惡性肉瘤及伊汶氏肉瘤施行化療合併自體幹細胞移植之結果及預後分析

4. 建立全台兒童癌症後之長期存活者其慢性健康狀況追蹤系統及分析

5. 研究幼年性骨髓單核球性白血病之異體幹細胞移植之成效

 

得獎事蹟

 

2015 AASPN Outstanding Award of the Abstract in Pediatric Neurosurgery/Oncology

2018, 2017 血液病學會年會  羅氏淋巴相關血液疾病研究獎

2020 退輔會台北榮民總醫院  年度優良醫師

2020 台北榮民總醫院實習醫學生票選  最佳教學主治醫師

2021 退輔會台北榮民總醫院  醫師學術論文獎

2021 台灣兒童腦瘤聯盟  優秀論文獎

2023, 2013, 2000 退輔會台北榮民總醫院  臨床教學績優醫師

2023, 2022, 2020, 2019, 2018, 2017  陽明大學醫學系  優良臨床醫師

 

[著作]

 

1. Ming-Hsin Hou, Chih-Ying Lee, Cheng-Yin Ho, .., Chun-Yu Liu, Hsiu-Ju Yen*. Donor Lymphocyte Infusion for Prophylaxis and Treatment of Relapse in Pediatric Hematologic Malignancies after Allogeneic HSCT. J Chin Med Assoc. 2023;86(11):991-1000. (2022 IF=2.994, rank: 78/169 (46.2%) in MEDICINE, GENERAL & INTERNAL)

2. Tai-Tong Wong, Min-Lan Tsai, Hsi Chang,…..Hsiu-Ju Yen, Yi-Wei Chen, Hsin-Lun Lee, Tsui-Fen Yang. Brain and Spinal Tumors Originating from the Germ Line Cells. Adv Exp Med Biol. 2023;1405:421-455. (2022 IF=3.650, rank: 33/94 (35.1%) in BIOLOGY)

3. Ming-Yun Hsieh, Hsin-Hung Chen, Chih-Ying Lee,…..Hsiu-Ju Yen*. A case series and literature review on 98 pediatric patients of germ cell tumor developing growing teratoma syndrome. Cancer Med. 2023;12(12):13256-13269. (2022 IF= 3.967, rank: 96/241 (39.8%) in ONCOLOGY)

4. Chih-Hsiang Yu, Shiann-Tarng Jou,.....Hsiu-Ju Yen,.....Ching-Hon Pui, Sung-Liang Yu, Yung-Li Yang. Clinical Impact of Minimal Residual Disease and Genetic Subtypes on the Prognosis of Childhood Acute Lymphoblastic Leukemia. Cancer. 2023;129(5):790-802. (2022 IF= 6.162, rank: 54/241 (22.4%) in ONCOLOGY)

5. Ting-Huan Huang, Giun-Yi Hung, Te-Fu Weng,.....Hsiu-Ju Yen,.....Yu-Mei Liao, Min-Yu Su, Ting-Chi Yeh, on behalf 13 of the Taiwan Pediatric Oncology Group. Surgical Treatment Confers Prognostic Significance in Pediatric Malignant Mediastinal Germ Cell Tumors. Cancer. 2022;1;128(23):4139-4149. (2022 IF= 6.162, rank: 54/241 (22.4%) in ONCOLOGY)

6. Chih-Hsiang Yu, Gang Wu, Chia-Ching Chang, Shiann-Tarng Jou,….Hsiu-Ju Yen,…..Ching-Hon Pui, Sung-Liang Yu, Yung-Li Yang. Sequential approach to improve the molecular classification of childhood acute lymphoblastic leukemia. J Mol Diagn. 2022;24(11):1195-1206. (2022 IF= 4.064, rank: 21/76 (27.6%) in PATHOLOGY)

7. Fu-Shiuan Whitney Lee, Chih-Ying Lee, Giun-Yi Hung, Min-Hua Tseng, Hsin-Hui Wang, Hsiu-Ju Yen*. Recurrent microangiopathic hemolysis after recovery from complement-mediated HUS during chemotherapy for a CFH-mutated patient with T-LBL. Int J Hematol. 2022;116(5):812-818. (2022 IF= 2.100, rank: 63/79 (79.8%) in HEMATOLOGY)

8. Wan-Ling Ho, Giun-Yi Hung, Hsiu-Ju Yen,...,,Shiann-Tarng Jou, Dong-Tsamn Lin. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group. J Formos Med Assoc. 2022;121(1):350-359. (2022 IF= 3.181, rank: 72/169 (42.6%) in MEDICINE, GENERAL & INTERNAL)

9. Yung-Li Yang, Tang-Her Jaing, Shih-Hsiang Chen, … Hsiu-Ju Yen,..., Yu-Mei Y Chao, Der-Cherng Liang, Tai-Tsung Chang. Treatment outcomes of pediatric acute myeloid leukemia: A retrospective analysis from 1996 to 2019 in Taiwan. Sci Rep. 2021;11(1):5893. (2022 IF= 4.562, rank: 22/73 (30.1%) in MULTIDISPLINARY SCIENCES)

10. Ying-Jung Huang, Hsi-Che Liu, Tang-Her Jaing, Kang-Hsi Wu,.... Hsiu-Ju Yen,…Tung-Huei Lin, Lee-Yung Shih. RAS pathway mutation is an added-value biomarker in pediatric Philadelphia-negative B-cell acute lymphoblastic leukemia with IKZF1 deletions. Pediatr Blood Cancer. 2021;68(4):e28899. (2022 IF= 3.194, rank: 34/130 (26.2%) in PEDIATRICS)

11. Hsin-Lien Tsai, Yi-Chen Yeh, Ting-Yen Yu, Chih-Ying Lee, Giun-Yi Hung, Yi-Ting Yeh, Chin-Su Liu, Hsiu-Ju Yen*. Complete and durable response to immune checkpoint inhibitor in a patient with refractory and metastatic hepatoblastoma. Pediatric Hematology Oncology. 2021;38(4):385-90. (2022 IF= 1.161, rank: 114/130 (87.7%) in PEDIATRICS)

12. Fu-Shiuan Lee, Hsiu-Ju Yen, Dau-Ming Niu, Giun-Yi Hung, Chih-Ying Lee, Yi-Chen Yeh, Paul Chih-Hsueh Chen, Sheng-Kai Chang, Chia-Feng Yang. Allogeneic hematopoietic stem cell transplantation for treating severe lung involvement in Gaucher disease. Mol Genet Metab Rep. 2020;25:100652. (2022 IF= 1.863, rank: 129/171 (75.4%) in GENETICS & HEREDITY)

13. Hsiu-Ju Yen, Jia-Rou Lin, Ya-Hsin Yeh, Jiun-Lin Horng, Li-Yih Lin. Exposure to colistin impairs skin keratinocytes and lateral-line hair cells in zebrafish embryos. Chemosphere.2020;263:128364. (2022 IF= 8.822, rank: 30/275 (10.9%) in ENVIRONMENTAL SCIENCES)

14. Hsiu-Ju Yen, Hesham M. Eissa, Neel S. Bhatt,….I-Chan Huang. Patient-Reported Outcomes in Survivors of Childhood Hematologic Malignancies with Hematopoietic Stem Cell Transplant. Blood. 2020;135(21):1847-58. (2022 IF= 20.337, rank: 3/79 (3.8%) in HEMATOLOGY)

15. Wan-Chin Yang, Hsiu-Ju Yen, Muh-Lii Liang,....Yi-Wei Chen. Effect of early radiotherapy initiation and high-dose chemotherapy on the prognosis of pediatric ATRT in different age groups. J Neuro-oncol. 2020;147(3):619-31. (2022 IF= 3.852, rank: 73/212 (34.4%) in CLINICAL NEUROLOGY)

16. Hsiu-Ju Yen, Jiun-Lin Horng, Ching-Hua Yu, Ching-Ya Fang, Ya-Hsin Yeh, Li-Yih Lin. Toxic effects of silver and copper nanoparticles on lateral-line hair cells of zebrafish embryos. Aquatic Toxicology. 2019;215:105273. (2022 IF= 4.549, rank: 7/109 (6.4%) in MARINE & FRESHWATER BIOLOGY)

17. Wan-Chin Yang, Hsiu-Ju Yen, Muh-Lii Liang,....Yi-Wei Chen. Role of early and aggressive post-operative radiation therapy in improving outcome for pediatric central nervous system ATRT. Childs Nerv Syst. 2019;35(6):1013-20. (2022 IF=1.445, rank: 159/213 (74.7%) in SURGERY)

18. Giun-Yi Hung, Ting-Yen Yu, Hsiu-Ju Yen, Ching-Fen Yang, Li-Yih Lin, Jiun-Lin Horng. Systemic Epstein-Barr Virus-positive T-Cell Lymphoma of Childhood Presentation with Hemophagocytosis. J Pediatr Hematol Oncol. 2019;41(4):319-20. (2022 IF= 1.163, rank: 114/130 (87.7%) in PEDIATRICS)

19. Hsiu-Ju Yen*, Ting-Yen Yu, Chih-Ying Lee,….Yi-Wei Chen. The Impact on Outcomes by Using Thiotepa in Tandem Transplant for Pediatric High-Risk Embryonal Brain Tumors. J Chin Med Assoc. 2019;82(2):148-54. (2022 IF=2.994, rank: 78/169 (46.2%) in MEDICINE, GENERAL & INTERNAL)

20. Ting-An Lin, Ching-Fen Yang, Yao-Chung Liu, Jin-Hwang Liu,…..Hsiu-Ju Yen,…..Sheng-Hsuan Chien, Jyh-Pyng Gau. Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population. Int J Hematol. 2019;109(2):187-96. (2022 IF= 2.100, rank: 63/79 (79.8%) in HEMATOLOGY)

21. Giun-Yi Hung, Chih-Ying Lee, Hsiu-Ju Yen, Li-Yih Lin, Jiun-Lin Horng. Incidence of immune thrombocytopenia in Taiwan: a nationwide population-based study. Transfusion. 2018;58(11):2712-9. (2022 IF= 2.923, rank: 48/79 (60.8%) in HEMATOLOGY)

22. Ting-Chi Yeh, Der-Cherng Liang, …., Hsiu-Ju Yen,…et al. Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study. Cancer. 2018;124(23):4538-47. (2022 IF= 6.162, rank: 54/241 (22.4%) in ONCOLOGY)

23. Giun-Yi Hung, Li-Yih Lin, Ting-Yen Yu, Chih-Ying Lee, Hsiu-Ju Yen, Jiun-Lin Horng. Hepatoblastoma incidence in Taiwan: A population-based study. J Chin Med Assoc. 2018;81(6):541-7. (2022 IF=2.994, rank: 78/169 (46.2%) in MEDICINE, GENERAL & INTERNAL)

24. Yi-Ting Yeh, Hsiu-Ju Yen, Niang-Cheng Lin, Kuo-Chiang Wang, Hsin-Lin Tsai, Chinsu Liu. Successful ABO-incompatible pediatric living donor liver transplantation in an infant with protein C deficiency. Pediatr Blood Cancer. 2017;64:e26521. (2022 IF= 3.194, rank: 34/130 (26.2%) in PEDIATRICS)

25. Hsiu-Ju Yen, Shih-Hsiang Chen, Tsung-Yen Chang,.…et al. Pediatric Acute Lymphoblastic Leukemia with t(1;19)/TCF3-PBX1 in Taiwan. Pediatr Blood Cancer. 2017;64(10):e26557. (2022 IF= 3.194, rank: 34/130 (26.2%) in PEDIATRICS)

26. §Meng-Ju Li, §Hsi-Che Liu, §Hsiu-Ju Yen,.…et al. Treatment for Childhood ALL in Taiwan: a TPOG 2002 Study Emphasizing the Optimal Reinduction Therapy and CNS Preventive Therapy without Cranial Radiation. Pediatr Blood Cancer. 2017;64(2):234-41. (2022 IF= 3.194, rank: 34/130 (26.2%) in PEDIATRICS)

27. Hsiu-Ju Yen, Wan-Hui Chang, Hsi-Che Liu, Ting-Chi Yeh, Giun-Yi Hung, et al. Outcomes Following Discontinuation of E. Coli L-Asparaginase upon Severe Allergic Reactions in Children with ALL. Pediatr Blood Cancer. 2016;63(4):665-70. (2022 IF= 3.194, rank: 34/130 (26.2%) in PEDIATRICS)

28. Giun-Yi Hung, Hsiu-Ju Yen, Chueh-Chuan Yen,….Hondar Wu, Hong-Jen Chiou, Wei-Ming Chen. Improvement in High-Grade Osteosarcoma Survival: Results from 202 Patients Treated at a Single Institution in Taiwan. Medicine (Baltimore). 2016;95(15):e3420. (2022 IF= 1.639, rank: 119/169 (70.4%) in MEDICINE, GENERAL & INTERNAL)

29. Chih-Ying Lee, Chueh-Chuan Yen, Hsiu-Ju Yen, Cheng-Ying Shiau, Ta-Chung Chao,,……., Giun-Yi Hung, Wei-Ming Chen. Outcomes of 50 Patients With Ewing Sarcoma Family of Tumors Treated at a Single Institution in Taiwan. Medicine (Baltimore). 2016;95(22):e3830. (2022 IF= 1.639, rank: 119/169 (70.4%) in MEDICINE, GENERAL & INTERNAL)

30. Chia-Yun Wu, Tzeon-Jye Chiou, Chun-Yu Liu, …. Hsiu-Ju Yen, ….Jing-Hwang Liu, Yuan-Bin Yu. Decision-tree algorithm for optimized hematopoietic progenitor cell-based predictions in peripheral blood stem cell mobilization. Transfusion. 2016;56(8):2042-51. (2022 IF= 2.923, rank: 48/79 (60.8%) in HEMATOLOGY)

31. Ming-Luen Lee, Hsiu-Ju Yen*, Shu-Jen Chen,….Wen-Jue Soong. Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis. Pediatr and Neonatol. 2016;57:149-52. (2022 IF= 2.136, rank: 66/130 (50.8%) in PEDIATRICS)