兒童血液腫瘤科主治醫師 顏秀如 醫師

兒童血液腫瘤科 專長: 兒童及青少年血液腫瘤 造血幹細胞移植 血液凝固疾病 新生兒血液疾病 新生兒學 門診時刻表

學歷

中國醫藥大學 醫學士

國立師範大學生命科學院 博士

 

經歷

美國St. Jude兒童癌症研究醫院及幹細胞移植中心 臨床研究員(2015/12-2016/5)

臺北榮民總醫院兒童醫學部 主治醫師

臺北榮民總醫院兒童血液腫瘤科及新生兒科 臨床研究員

 

現任

臺北榮民總醫院兒童醫學部血液腫瘤科 主治醫師

國立陽明交通大學醫學院小兒學科 助理教授

中華民國兒童癌症基金會 顧問醫師  

 

證照

中華民國血液病專科醫師

中華民國血液及骨髓移植專科醫師

台灣癌症安寧緩和醫學專科醫師

中華民國兒科專科醫師

中華民國新生兒科專科醫師

兒童重症醫學專科醫師

兒童急診醫學專科醫師

 

研究

1. 探討兒童白血病或淋巴癌之化學治療結果、危險分析、及異體造血幹細胞移植
2. 探討兒童高危險腦瘤之治療及造血幹細胞移植之結果及預後分析
3. 探討惡性肉瘤及伊汶氏肉瘤施行化療合併自體幹細胞移植之結果及預後分析
4. 建立全台兒童癌症後之長期存活者其慢性健康狀況追蹤系統及分析
5. 研究幼年性骨髓單核球性白血病之異體幹細胞移植之成效

 

得獎事蹟

2015 AASPN Outstanding Award of the Abstract in Pediatric Neurosurgery/Oncology

2017, 2018, 2019, 2020 陽明大學醫學系  優良臨床醫師

2017, 2018 血液病學會年會  羅氏淋巴相關血液疾病研究獎

2000, 2013 退輔會台北榮民總醫院  臨床教學績優醫師

2020 學年度台北榮民總醫院實習醫學生票選  最佳教學主治醫師

2020 退輔會台北榮民總醫院  年度優良醫師

2021台灣兒童腦瘤聯盟  優秀論文獎

2021 退輔會台北榮民總醫院  醫師學術論文獎第三名

 

[著作]

1. Chih-Hsiang Yu, Shiann-Tarng Jou, Ying-Hui Su,.....Hsiu-Ju Yen,.....Ching-Hon Pui, Sung-Liang Yu, Yung-Li Yang. Clinical Impact of Minimal Residual Disease and Genetic Subtypes on the Prognosis of Childhood Acute Lymphoblastic Leukemia Running title: Impacts of MRD and Subtypes on ALL. Cancer. 2022. Accepted. (2021 IF= 6.921, rank: 55/245 (22.4%) in ONCOLOGY)

2. Ting-Huan Huang, Giun-Yi Hung, Te-Fu Weng,.....Hsiu-Ju Yen,.....Yu-Mei Liao, Min-Yu Su, Ting-Chi Yeh, on behalf 13 of the Taiwan Pediatric Oncology Group. Surgical Treatment Confers Prognostic Significance in Pediatric Malignant Mediastinal Germ Cell Tumors. Cancer. 2022;1;128(23):4139-4149. doi: 10.1002/cncr.34494. (2021 IF= 6.921, rank: 55/245 (22.4%) in ONCOLOGY)

3. CH Yu, G Wu, CC Chang,…Hsiu-Ju Yen. Sequential Approach to Improve the Molecular Classification of Childhood Acute Lymphoblastic Leukemia. J Mol Diagn. 2022;24(11):1195-1206. doi: 10.1016/j.jmoldx.2022.08.001. (2021 IF= 5.341, rank: 18/77 (23.4%) in PATHOLOGY)

4. Lee FS, Lee CY 1 2, Hung GY, … Hsiu-Ju Yen*. Recurrent microangiopathic hemolysis after recovery from complement-mediated hemolytic uremia syndrome during chemotherapy for a CFH-mutated patient with T-lymphoblastic lymphoma. Int J Hematol. 2022. https://doi.org/10.1007/s12185-022-03409-6 (2021 IF= 2.329, rank: 64/78 (82.1%) in HEMATOLOGY)

5. Ho WL, Hung GY, Hsiu-Ju Yen, ...,, Lin DT. Characteristics and outcomes of second cancers in patients with childhood cancer: A report from the Taiwan Pediatric Oncology Group. J Formos Med Assoc. 2021; 18:S0929-6646(21)00227-8. (2021 IF= 3.871, rank: 61/172 (35.5%) in MEDICINE, GENERAL & INTERNAL)

6. Yang YL, Jaing TH, Chen SH, … Hsiu-Ju Yen,..., Liang DC, Chang TT. Treatment outcomes of pediatric acute myeloid leukemia: A retrospective analysis from 1996 to 2019 in Taiwan. Sci Rep. 2021;11(1):5893. (2021 IF= 4.996, rank: 19/73 (26.0%) in MULTIDISPLINARY SCIENCES)
 
7. Ying-Jung Huang, Hsi-Che Liu, Tang-Her Jaing, Kang-Hsi Wu,.... Hsiu-Ju Yen,…Tung-Huei Lin, Lee-Yung Shih. RAS pathway mutation is an added-value biomarker in pediatric Philadelphia-negative B-cell acute lymphoblastic leukemia with IKZF1 deletions. Pediatr Blood Cancer. 2021;68(4):e28899. (2021 IF= 3.838, rank: 30/130 (23.1%) in PEDIATRICS)

8. Hsin-Lien Tsai, Yi-Chen Yeh, Ting-Yen Yu, Chih-Ying Lee, Giun-Yi Hung, Yi-Ting Yeh, Chin-Su Liu, Hsiu-Ju Yen*. Complete and durable response to immune checkpoint inhibitor in a patient with refractory and metastatic hepatoblastoma. Pediatric Hematology Oncology. 2021;38(4):385-90. (2021 IF= 1.170, rank: 119/130 (91.5%) in PEDIATRICS)

9. Lee FS, Hsiu-Ju Yen, Niu DM, Hung GY, Lee CY, Yeh YC, Chen PC, Chang SK, Yang CF.Allogeneic hematopoietic stem cell transplantation for treating severe lung involvement in Gaucher disease. Mol Genet Metab Rep. 2020;25:100652. (2021 IF= 2.082, rank: 141/175 (80.6%) in GENETICS & HEREDITY)

10. Hsiu-Ju Yen, Jia-Rou Lin, Ya-Hsin Yeh, Jiun-Lin Horng, Li-Yih Lin. Exposure to colistin impairs skin keratinocytes and lateral-line hair cells in zebrafish embryos. Chemosphere. 2020;263:128364. (2021 IF= 8.943, rank: 33/279 (11.8%) in ENVIRONMENTAL SCIENCES)

11. Hsiu-Ju Yen, Hesham M. Eissa, Neel S. Bhatt, Sujuan Huang, Matthew J. Ehrhardt,…. Leslie L. Robison, Melissa M. Hudson, I-Chan Huang. Patient-Reported Outcomes in Survivors of Childhood Hematologic Malignancies with Hematopoietic Stem Cell Transplant. Blood. 2020;135(21):1847-58. (2021 IF= 25.476, rank: 2/78 (2.6%) in HEMATOLOGY)

12. Yang WC, Hsiu-Ju Yen, Liang ML, Chen HH, Lee YY, Chang FC, Lin SC, Wong TT, Hu YW, Chen YW. Effect of early radiotherapy initiation and high-dose chemotherapy on the prognosis of pediatric atypical teratoid rhabdoid tumors in different age groups. J Neurooncol. 2020;147(3):619-31. (2021 IF= 4.506, rank: 73/212 (34.4%) in CLINICAL NEUROLOGY) 

13. Hsiu-Ju Yen, Jiun-Lin Horng, Ching-Hua Yu, Ching-Ya Fang, Ya-Hsin Yeh, Li-Yih Lin. Toxic effects of silver and copper nanoparticles on lateral-line hair cells of zebrafish embryos. Aquatic Toxicology. 2019;215:105273. (2021 IF= 5.202, rank: 7/113 (6.2%) in MARINE & FRESHWATER BIOLOGY)

14. Yang WC, Hsiu-Ju Yen, Liang ML, Chen HH, Lee YY, Wong TT, Hu YW, Chen YW. Role of early and aggressive post-operative radiation therapy in improving outcome for pediatric central nervous system atypical teratoid/rhabdoid tumor. Childs Nerv Syst. 2019;35(6):1013-20. (2021 IF= 1.532, rank: 164/211 (77.7%) in SURGERY)

15. Hung GY, Yu TY, Hsiu-Ju Yen, Yang CF, Lin LY, Horng JL. Systemic Epstein-Barr Virus-positive T-Cell Lymphoma of Childhood Presentation with Hemophagocytosis. J Pediatr Hematol Oncol. 2019;41(4):319-20. (2021 IF= 1.170, rank: 119/130 (91.5%) in PEDIATRICS)

16. Hsiu-Ju Yen*, Ting-Yen Yu, Chih-Ying Lee, Giun-Yi Hung, Tzeon-Jye Chiou,….Yi-Wei Chen. The Impact on Outcomes by Using Thiotepa in Tandem Transplant for Pediatric High-Risk Embryonal Brain Tumors. J Chin Med Assoc. 2019;82(2):148-54. (2021 IF= 3.396, rank: 71/172 (41.3%) in MEDICINE, GENERAL & INTERNAL)

17. Lin TA, Yang CF, Liu YC, Liu JH, Chiou TJ, Hsiao LT, Hsiu-Ju Yen, Liu CJ, Wang HY, Ko PS, Chien SH, Gau JP. Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population. Int J Hematol. 2019;109(2):187-96. (2021 IF= 2.329, rank: 64/78 (82.1%) in HEMATOLOGY)
 
18. Giun-Yi Hung, Chih-Ying Lee, Hsiu-Ju Yen, Li-Yih Lin, Jiun-Lin Horng. Incidence of immune thrombocytopenia in Taiwan: a nationwide population-based study. Transfusion. 2018;58(11):2712-9. (2021 IF= 3.337, rank: 48/78 (61.5%) in HEMATOLOGY)
 
19. Ting-Chi Yeh, Der-Cherng Liang, …., Hsiu-Ju Yen,…et al. Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study. Cancer. 2018;124(23):4538-47. (2021 IF= 6.921, rank: 55/245 (22.4%) in ONCOLOGY)

20. Hung GY, Lin LY, Yu TY, Lee CY, Hsiu-Ju Yen, Horng JL. Hepatoblastoma incidence in Taiwan: A population-based study. J Chin Med Assoc. 2018;81(6):541-7. (2021 IF= 3.396, rank: 71/172 (41.3%) in MEDICINE, GENERAL & INTERNAL)

21. Yeh YT, Hsiu-Ju Yen, Lin NC, Wang KC, Tsai HL, Liu C. Successful ABO-incompatible pediatric living donor liver transplantation in an infant with protein C deficiency. Pediatr Blood Cancer. 2017;64:e26521. (2021 IF= 3.838, rank: 30/130 (23.1%) in PEDIATRICS)

22. Hsiu-Ju Yen, Shih-Hsiang Chen, Tsung-Yen Chang,.….et al. Pediatric Acute Lymphoblastic Leukemia with t(1;19)/TCF3-PBX1 in Taiwan. Pediatr Blood Cancer. 2017;64:e26557. (2021 IF= 3.838, rank: 30/130 (23.1%) in PEDIATRICS)

23. §Meng-Ju Li, §Hsi-Che Liu, §Hsiu-Ju Yen, Tang-Her Jaing,.….et al. Treatment for Childhood ALL in Taiwan: a TPOG 2002 Study Emphasizing the Optimal Reinduction Therapy and CNS Preventive Therapy without Cranial Radiation. Pediatr Blood Cancer. 2017;64(2):234-41. §Equal contribution (2021 IF= 3.838, rank: 30/130 (23.1%) in PEDIATRICS)

24. Hsiu-Ju Yen, Wan-Hui Chang, Hsi-Che Liu, Ting-Chi Yeh, Giun-Yi Hung, et al. Outcomes Following Discontinuation of E. Coli L-Asparaginase upon Severe Allergic Reactions in Children with Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 2016;63(4):665-70. (2021 IF= 3.838, rank: 30/130 (23.1%) in PEDIATRICS)

25. Giun-Yi Hung, Hsiu-Ju Yen, Chueh-Chuan Yen,….Hondar Wu, Hong-Jen Chiou, Wei-Ming Chen. Improvement in High-Grade Osteosarcoma Survival: Results from 202 Patients Treated at a Single Institution in Taiwan. Medicine (Baltimore). 2016;95(15):e3420. (2021 IF= 1.817, rank: 122/172 (70.9%) in MEDICINE, GENERAL & INTERNAL)

26. Chih-Ying Lee, Chueh-Chuan Yen, Hsiu-Ju Yen, Cheng-Ying Shiau, Ta-Chung Chao,,……., Giun-Yi Hung, Wei-Ming Chen. Outcomes of 50 Patients With Ewing Sarcoma Family of Tumors Treated at a Single Institution in Taiwan. Medicine (Baltimore). 2016;95(22):e3830. (2021 IF= 1.817, rank: 122/172 (70.9%) in MEDICINE, GENERAL & INTERNAL)

27. Chia-Yun Wu, Tzeon-Jye Chiou, Chun-Yu Liu, …. Hsiu-Ju Yen, ….Jing-Hwang Liu, Yuan-Bin Yu. Decision-tree algorithm for optimized hematopoietic progenitor cell-based predictions in peripheral blood stem cell mobilization. Transfusion. 2016;56(8):2042-51. (2021 IF= 3.337, rank: 48/78 (61.5%) in HEMATOLOGY)

28. Ming-Luen Lee, *Hsiu-Ju Yen, Shu-Jen Chen,….Wen-Jue Soong. Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis. Pediatr and Neonatol. 2016;57:149-52. (2021 IF= 2.586, rank: 67/130 (51.5%) in PEDIATRICS)

29. Meng-Ju Li, Ni-Chung Lee, Yung-Li Yang, Hsiu-Ju Yen, Hsiu-Hao Chang, Yin-Hsiu Chien, Meng-Yao Lu,….Dong-Tsamn Lin. Long-term outcome for Down syndrome patients with hematopoietic disorders. J Formos Med Assoc. 2016;115(2):94-9. (2021 IF= 3.871, rank: 61/172 (35.5%) in MEDICINE, GENERAL & INTERNAL)

30. Chih-Ying Lee, Mu-Hong Chen, Mei-Jy Jeng, Ju-Wei Hsu,….Hsiu-Ju Yen,….Tung-Ping Su. Longitudinal association between early atopic dermatitis and subsequent attention-deficit or autistic disorder: A population-based case-control study. Medicine (Baltimore). 2016;95(39):e5005. (2021 IF= 1.817, rank: 122/172 (70.9%) in MEDICINE, GENERAL & INTERNAL)

31. Yu-Sheng Lee, Yung-Tai Chen, Mei-Jy Jeng, Pei-Chen Tsao, Hsiu-Ju Yen, Pi-Chang Lee,….Wen-Jue Soong. The Risk of Cancer in Patients with Congenital Heart Disease: A Nationwide Population-Based Cohort Study in Taiwan. PLoS One. 2015;23;10(2):e0116844. (2021 IF= 3.752, rank: 29/73 (39.7%) in MULTIDISPLINARY SCIENCES)

32. Giun-Yi Hung, Jiun-Lin Horng, Hsiu-Ju Yen, Chih-Ying Lee, Yu-Sheng Lee. Geographic Variation in Cancer Incidence among Children and Adolescents in Taiwan (1995-2009). PLoS One. 2015;20;10(7):e0133051. (2021 IF= 3.752, rank: 29/73 (39.7%) in MULTIDISPLINARY SCIENCES)

33. Giun-Yi Hung, Jiun-Lin Horng, Hsiu-Ju Yen, Chih-Ying Lee, Li-Yih Lin. Changing Incidence Patterns of Hepatocellular Carcinoma Among Age Groups in Taiwan. J Hepatol. 2015;63(6):1390-6. (2021 IF= 30.083, rank: 5/93 (5.8%) in GASTROENTEROLOGY & HEPATOLOGY)

34. Giun-Yi Hung, Jiun-Lin Horng, Hsiu-Ju Yen, Chih-Ying Lee. Infant Cancer in Taiwan: Incidence and Trends (1995-2009). PLoS One. 2015;25;10(6):e0130444. (2021 IF= 3.752, rank: 29/73 (39.7%) in MULTIDISPLINARY SCIENCES)

35. Giun-Yi Hung, Hsiu-Ju Yen, Chueh-Chuan Yen, Wei-Ming Chen,….Hung-Ta Hondar Wu, Hong-Jen Chiou, Chang WH, Hsu HE. Experience of Pediatric Osteosarcoma of the Extremity at a Single Institution in Taiwan: Prognostic Factors and Impact on Survival. Ann Surg Oncol. 2015;22(4):1080-7. (2021 IF= 4.339, rank: 37/211 (17.5%) in SURGERY)

36. Giun-Yi Hung, Jiun-Lin Horng, Hsiu-Ju Yen, Chueh-Chuan Yen, Wei-Ming Chen, Paul Chih-Hsueh Chen, Hung-Ta Hondar Wu, Hong-Jen Chiou. Incidence Patterns of Primary Bone Cancer in Taiwan (2003-2010): A Population-Based Study. Ann Surg Oncol. 2014;21(8):2490-8. (2021 IF= 4.339, rank: 37/211 (17.5%) in SURGERY)

37. Giun-Yi Hung, Jiun-Lin Horng, Yu-Sheng Lee, Hsiu-Ju Yen, Chao-Chun Chen, Chih-Yinig Lee. Cancer Incidence Patterns among Children and Adolescents in Taiwan from 1995 to 2009: a Population-Based Study. Cancer. 2014;120(22):3545-53. (2021 IF= 6.921, rank: 55/245 (22.4%) in ONCOLOGY)

38. Shu-Fan Tsai, Shu-Jen Chen, Hsiu-Ju Yen, Giun-Yi Hung, Pei-Chen Tsao, Mei-Jy Jeng, Yu-Sheng Lee, Wen-Jue Soong, Ren-Bin Tang. Iron Deficiency Anemia in Young Children with Predominant Breastfeeding. Pediatr Neonatol. 2014;55(6):466-9. (2021 IF= 2.586, rank: 67/130 (51.5%) in PEDIATRICS)
  
39. Hsin-Lin Tsai, Ling-Yu Yang, Tai-Wai Chin, Po-Hon Chen, Hsiu-Ju Yen, Chin-Su Liu, Hsin-Hui Wang, Jei-Wen Chang. Child abuse in medical setting presenting as gross hematuria: diagnosis by DNA short tandem repeats. Pediatrics. 2012;130(1):e224-9. (2021 IF= 9.703, rank: 4/130 (3.1%) in PEDIATRICS)

40. Pei-Chen Tsao, Feng-Yu Chang, Shu-Jen Chen, Wen-Jue Soong, Mei-Jy Jeng, Yu-Sheng Lee, Hsiu-Ju Yen, Chia-Feng Yang, Ren-Bin Tang. Sudden and unexpected and near death during the early neonatal period: A multicenter study. J Chin Med Assoc. 2012;75(2):65-9. (2021 IF= 3.396, rank: 71/172 (41.3%) in MEDICINE, GENERAL & INTERNAL)

41. Wen-I Lee, Jing-Long Huang, Tang-Her Jaing, … Hsiu-Ju Yen,.…Kuei-Wen Chang. Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary PIDs in a nationwide population-based study during 1985-2010. Immunobiology. 2011;216(12):1286-94. (2021 IF= 3.152, rank: 124/161 (77.0%) in IMMUNOLOGY)

42. Ting-Yao Wang, *Hsiu-Ju Yen, Giun-Yi Hung, Ming-Yun Hsieh, Ren-Bin Tang. A Rare Complication in a Child Undergoing Chemotherapy for Acute Lymphoblastic Leukemia: Superior Sagittal Sinus Thrombosis. J Chin Med Assoc. 2011;74(4):183-7. (2021 IF= 3.396, rank: 71/172 (41.3%) in MEDICINE, GENERAL & INTERNAL)

43. Ming-Yun Hsieh, Tzeon-Jye Chiou, Giun-Yi Hung, Hsiu-Ju Yen. Outcomes of Matched Sibling and Alternative Donor Stem Cell Transplantation for 26 Children with Severe Aplastic Anemia. Int J of Hematol. 2010;91(1):54-60. (2021 IF= 2.329, rank: 64/78 (82.1%) in HEMATOLOGY)

44. Shen YM, Giun-Yi Hung, Hsiu-Ju Yen, Ming-Yun Hsieh, Hsieh TK. Early development of acute myeloid leukemia following treatment of osteosarcoma: a case report and review of the literature. Pediatr Neonatol. 2009;50(5):239-44. (2021 IF= 2.586, rank: 67/130 (51.3%) in PEDIATRICS)

45. Ming-Yun Hsieh, Giun-Yi Hung, Hsiu-Ju Yen, Wei-Ming Chen, Tain-Hsiung Chen. Osteosarcoma in preadolescent patients: experience in a single institute in Taiwan. J Chin Med Assoc. 2009;72(9):455-61. (2021 IF= 3.396, rank: 71/172 (41.3%) in MEDICINE, GENERAL & INTERNAL)

46. Hsiu-Ju Yen, Tzeon-Jye Chiou, Giun-Yi Hung, Chia-Yau Chang, Ming-Yun Hsieh, Cheng-Hwai Tzeng, Po-Min Chen, Ren-Bin Tang. Long-term mixed full-donor chimerism with dominance reversion after a double-unit cord blood transplant. Eur J Haematol. 2008;80(4):366-7. (2021 IF= 3.674, rank: 42/78 (53.8%) in HEMATOLOGY)

47. Hao-Chuan Liu, Giun-Yi Hung, Hsiu-Ju Yen, Ming-Yun Hsieh, Tzeon-Jye Chiou. Acute sciatica: an unusual presentation of extramedullary relapse of ALL. Int J Hematol. 2007;86(2):163-5. (2021 IF= 2.329, rank: 64/78 (82.1%) in HEMATOLOGY)